Research Project
Grant-in-Aid for Challenging Exploratory Research
The present report demonstrates efficacy of fluorescence-guided surgery (FGS) to resect and prevent recurrence of experimental skeletal metastasis in a nude-mouse model of human prostate cancer. Green fluorescent protein (GFP)-expressing PC-3human prostate cancer cells were injected into the intramedullary cavity of the tibia in 25 nude mice. One week after implantation, monoclonal antibodies, specific for carcinoembryonic antigen (CEA), labeled with DyLight 650, were injected into the tail vein of 13 mice. Thirteen mice underwent FGS and 12 mice underwent bright-light surgery (BLS). Weekly GFP fluorescence imaging of the micewas performed to observe tumor recurrence. FGS group showed only slight tumor growth and significantly improved disease-free survival of the treated mice. Our study demonstrated that FGS significantly reduced residual tumor as well as the recurrence of experimental prostate-cancer bone metastasis.
All 2018 2017 2016
All Journal Article (70 results) (of which Int'l Joint Research: 13 results, Peer Reviewed: 70 results, Open Access: 25 results, Acknowledgement Compliant: 2 results) Presentation (28 results) (of which Int'l Joint Research: 13 results, Invited: 20 results) Book (1 results)
Cancer Med.
Volume: 印刷中 Issue: 5 Pages: 1944-1954
10.1002/cam4.1438
120006605139
Oncology Letters
Volume: 15 Pages: 4627-4634
10.3892/ol.2018.7902
Knee Surg Sports Traumatol Arthrosc
Volume: 印刷中 Issue: 10 Pages: 3004-3011
10.1007/s00167-018-4888-4
BMC Surg
Volume: 18 Issue: 1 Pages: 12-12
10.1186/s12893-018-0346-y
Biochem Biophys Res Commun
Volume: 497 Issue: 4 Pages: 1055-1061
10.1016/j.bbrc.2018.02.174
Cancer Med
Volume: 印刷中 Issue: 4 Pages: 1560-1571
10.1002/cam4.1366
J Orthop Sci
Volume: 印刷中 Issue: 5 Pages: 684-688
10.1177/1558944718760003
Volume: 印刷中 Issue: 3 Pages: 459-463
10.1016/j.jos.2018.01.004
J Orthop Res
Volume: 印刷中 Issue: 6 Pages: 1590-1598
10.1002/jor.23801
Mod Rheumatol
Volume: 印刷中 Issue: 6 Pages: 1029-1034
10.1080/14397595.2018.1436119
Cell Cycle
Volume: 印刷中 Issue: 6 Pages: 801-809
10.1080/15384101.2018.1431596
PLoS One
Volume: 13 Issue: 1 Pages: e0191679-e0191679
10.1371/journal.pone.0191679
120006454994
Knee
Volume: 25 Issue: 1 Pages: 15-24
10.1016/j.knee.2017.11.008
J Surg Oncol.
Volume: 印刷中 Issue: 6 Pages: 1232-1238
10.1002/jso.24971
Cancer Lett
Volume: 417 Pages: 168-173
10.1016/j.canlet.2017.12.028
Anticancer Res
Volume: 38 Pages: 577-582
J Cell Biochem
Volume: 119 Issue: 4 Pages: 3537-3544
10.1002/jcb.26527
Int Orthop
Volume: 印刷中 Issue: 5 Pages: 1021-1028
10.1007/s00264-017-3653-5
Spine J
Volume: 18 Issue: 3 Pages: 381-386
10.1016/j.spinee.2017.07.169
Oncotarget
Volume: 9 Issue: 8 Pages: 7774-7781
10.18632/oncotarget.22892
120006454991
Immunotherapy
Volume: 9 Issue: 16 Pages: 1331-1338
10.2217/imt-2017-0101
120006454997
Volume: 12 Issue: 11 Pages: e0187438-e0187438
10.1371/journal.pone.0187438
120006374163
Volume: 8 Issue: 44 Pages: 75874-75880
10.18632/oncotarget.16548
Journal of Surgical Oncology
Volume: 115 Issue: 6 Pages: 760-767
10.1002/jso.24567
Volume: 24 Issue: 6 Pages: 1428-1434
10.1016/j.knee.2017.07.017
Volume: 8 Issue: 37 Pages: 62111-62119
10.18632/oncotarget.19095
Volume: 8 Issue: 38 Pages: 63353-63359
10.18632/oncotarget.18806
J Knee Surg. 2017
Volume: 5 Issue: 08 Pages: 1-1
10.1055/s-0037-1606377
Volume: 37 Pages: 4807-4812
Volume: 26 Issue: 2 Pages: 442-447
10.1007/s00167-017-4681-9
Skeletal Radiol
Volume: 47 Issue: 1 Pages: 61-68
10.1007/s00256-017-2760-0
J Hand Surg Asian Pac Vol
Volume: 22 Pages: 337-342
Volume: 37 Pages: 4081-4084
Volume: 41 Issue: 10 Pages: 2189-2197
10.1007/s00264-017-3499-x
120006343969
Volume: 22 Issue: 5 Pages: 905-908
10.1016/j.jos.2017.05.007
Molecular Medicine Reports
Volume: 16 Issue: 1 Pages: 403-409
10.3892/mmr.2017.6589
World J Surg Oncol
Volume: 15 Issue: 1 Pages: 102-102
10.1186/s12957-017-1166-8
Volume: 16 Issue: 12 Pages: 1164-1170
10.1080/15384101.2017.1317417
Eur Spine J
Volume: 26 Issue: S1 Pages: 236-242
10.1007/s00586-017-5086-7
Volume: 41 Issue: 6 Pages: 1093-1099
10.1007/s00264-017-3477-3
Volume: 41 Issue: 7 Pages: 1481-1487
10.1007/s00264-017-3446-x
Eur J Orthop Surg Traumatol
Volume: 27 Issue: 8 Pages: 1131-1138
10.1007/s00590-017-1946-4
Volume: 37 Pages: 1005-1011
Cancer
Volume: 123 Issue: 9 Pages: 1576-84
10.1002/cncr.30606
Volume: 12 Issue: 2 Pages: e0172934-e0172934
10.1371/journal.pone.0172934
Volume: 37 Pages: 749-754
Volume: 118 Issue: 9 Pages: 2739-2743
10.1002/jcb.25923
Hip Int
Volume: 27 Issue: 4 Pages: 361-367
10.5301/hipint.5000466
Volume: 27 Issue: 3 Pages: 273-280
10.5301/hipint.5000463
Clin Orthop Relat Res
Volume: 印刷中 Issue: 6 Pages: 1693-1701
10.1007/s11999-017-5259-z
Volume: 15 Issue: 1 Pages: 1-1
10.1186/s12957-016-1068-1
Volume: 16 Issue: 1 Pages: 91-94
10.1080/15384101.2016.1252885
Volume: 118 Issue: 1 Pages: 26-30
10.1002/jcb.25603
J Bone Oncol
Volume: 5 Issue: 4 Pages: 163-166
10.1016/j.jbo.2016.06.001
120005982984
Volume: 36 Pages: 6631-6635
Volume: 7 Issue: 52 Pages: 87031-87036
10.18632/oncotarget.13497
Volume: 7 Issue: 47 Pages: 77038-51
10.18632/oncotarget.12781
Volume: 36 Pages: 4477-82
Volume: 36 Pages: 3821-6
Volume: 36 Pages: 3811-6
BMC Musculoskelet Disord
Volume: 17 Issue: 1 Pages: 306-306
10.1186/s12891-016-1163-z
Volume: 5 Issue: 9 Pages: 2343-9
10.1002/cam4.823
BMC Cancer
Volume: 16 Issue: 1 Pages: 442-442
10.1186/s12885-016-2524-6
Volume: 7 Issue: 29 Pages: 46315-46320
10.18632/oncotarget.10111
Volume: 36 Pages: 2893-7
Jpn J Clin Oncol
Volume: 46 Issue: 8 Pages: 735-40
10.1093/jjco/hyw065
120005899104
Volume: 17 Issue: 1 Pages: 180-180
10.1186/s12891-016-1050-7
Volume: 117 Issue: 11 Pages: 2533-2537
10.1002/jcb.25545
J Surg Oncol
Volume: 113 Issue: 5 Pages: 587-92
10.1002/jso.24186
Journal of Orthopedic Research
Volume: 34 Issue: 4 Pages: 559-65
10.1002/jor.22973