Investigation of mechanism of bone metastasis and the novel treatment of metastatic bone tumor

• Project/Area Number: 16K15658
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kanazawa University
• Principal Investigator: Tsuchiya Hiroyuki 金沢大学, 医学系, 教授 (40227434)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 骨転移 / 蛍光タンパク / 腫瘍切除術 / 蛍光イメージング / 蛍光ガイド下手術 / がん / 癌 / 骨髄 / 蛍光蛋白 / 転移

Outline of Final Research Achievements

The present report demonstrates efficacy of fluorescence-guided surgery (FGS) to resect and prevent recurrence of experimental skeletal metastasis in a nude-mouse model of human prostate cancer. Green fluorescent protein (GFP)-expressing PC-3
human prostate cancer cells were injected into the intramedullary cavity of the tibia in 25 nude mice. One week after implantation, monoclonal antibodies, specific for carcinoembryonic antigen (CEA), labeled with DyLight 650, were injected into the tail vein of 13 mice. Thirteen mice underwent FGS and 12 mice underwent bright-light surgery (BLS). Weekly GFP fluorescence imaging of the mice
was performed to observe tumor recurrence. FGS group showed only slight tumor growth and significantly improved disease-free survival of the treated mice. Our study demonstrated that FGS significantly reduced residual tumor as well as the recurrence of experimental prostate-cancer bone metastasis.

Research Products

• [Journal Article] Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression. (2018)
  • Author(s): Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.
  • Journal Title: Cancer Med. Volume: 印刷中 Issue: 5 Pages: 1944-1954
  • DOI: 10.1002/cam4.1438
  • NAID: 120006605139
  • Peer Reviewed / Open Access
• [Journal Article] In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system (2018)
  • Author(s): El-Far Ali、Munesue Seiichi、Harashima Ai、Sato Akira、Shindo Mika、Nakajima Shingo、Inada Mana、Tanaka Mariko、Takeuchi Akihiko、Tsuchiya Hiroyuki、Yamamoto Hiroshi、Shaheen Hazem、El-Sayed Yasser、Kawano Shuhei、Tanuma Sei-Ichi、Yamamoto Yasuhiko
  • Journal Title: Oncology Letters Volume: 15 Pages: 4627-4634
  • DOI: 10.3892/ol.2018.7902
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Greater body mass index and hip abduction muscle strength predict noncontact anterior cruciate ligament injury in female Japanese high school basketball players (2018)
  • Author(s): Shimozaki K, Nakase J, Takata Y, Shima Y, Kitaoka K, Tsuchiya H
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: 印刷中 Issue: 10 Pages: 3004-3011
  • DOI: 10.1007/s00167-018-4888-4
  • Peer Reviewed
• [Journal Article] Successful joint preservation of distal radius osteosarcoma by en bloc tumor excision and reconstruction using a tumor bearing frozen autograft: a case report (2018)
  • Author(s): Higuchi T、Yamamoto N、Hayashi K、Takeuchi A、Abe K、Taniguchi Y、Araki Y、Tada K、Tsuchiya H
  • Journal Title: BMC Surg Volume: 18 Issue: 1 Pages: 12-12
  • DOI: 10.1186/s12893-018-0346-y
  • Peer Reviewed / Open Access
• [Journal Article] Tumor-targeting Salmonella typhimurium A1-R is a highly effective general therapeutic for undifferentiated soft tissue sarcoma patient-derived orthotopic xenograft nude-mouse models (2018)
  • Author(s): Igarashi K、Kawaguchi K、Kiyuna T、Miyake K、Miyake M、Singh AS、Eckardt MA、Nelson SD、Russell TA、Dry SM、Li Y、Yamamoto N、Hayashi K、Kimura H、Miwa S、Tsuchiya H、Singh SR、Eilber FC、Hoffman RM
  • Journal Title: Biochem Biophys Res Commun Volume: 497 Issue: 4 Pages: 1055-1061
  • DOI: 10.1016/j.bbrc.2018.02.174
  • Peer Reviewed
• [Journal Article] Clinical outcomes of radio-hyperthermo-chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched-pair cohort study (2018)
  • Author(s): Aiba H、Yamada S、Mizutani Jun、Yamamoto Norio、Okamoto Hideki、Hayashi Katsuhiro、Kimura Hiroaki、Takeuchi Akihiko、Miwa Shinji、Kawai Akira、Yoshimura Kenichi、Tsuchiya Hiroyuki、Takanobu Otsuka
  • Journal Title: Cancer Med Volume: 印刷中 Issue: 4 Pages: 1560-1571
  • DOI: 10.1002/cam4.1366
  • Peer Reviewed / Open Access
• [Journal Article] Tin Ring Splint Treatment for Osteoarthritis of the Distal Interphalangeal Joints (2018)
  • Author(s): Tada Kaoru、Toribatake Yasumitsu、Yamamoto Daiki、Nakajima Tadahiro、Nakada Mika、Matsuta Masashi、Tsuchiya Hiroyuki
  • Journal Title: J Orthop Sci Volume: 印刷中 Issue: 5 Pages: 684-688
  • DOI: 10.1177/1558944718760003
  • Peer Reviewed
• [Journal Article] Risk factors for local recurrence after total en bloc spondylectomy for metastatic spinal tumors: A retrospective study (2018)
  • Author(s): Igarashi Takashi、Murakami Hideki、Demura Satoru、Kato Satoshi、Yoshioka Katsuhito、Yokogawa Noriaki、Tsuchiya Hiroyuki
  • Journal Title: J Orthop Sci Volume: 印刷中 Issue: 3 Pages: 459-463
  • DOI: 10.1016/j.jos.2018.01.004
  • Peer Reviewed
• [Journal Article] Immunotherapy synergizes with debridement and antibiotic therapy in a murine 1-stage exchange model of MRSA implant-associated osteomyelitis (2018)
  • Author(s): Yokogawa Noriaki、Ishikawa Masahiro、Nishitani Kohei、Beck Christopher A.、Tsuchiya Hiroyuki、Mesfin Addisu、Kates Stephen L.、Daiss John L.、Xie Chao、Schwarz Edward M.
  • Journal Title: J Orthop Res Volume: 印刷中 Issue: 6 Pages: 1590-1598
  • DOI: 10.1002/jor.23801
  • Peer Reviewed
• [Journal Article] Three-dimensional limb lengthening after total knee arthroplasty in a simulation study (2018)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Inoue Daisuke、Taga Tadashi、Yamamoto Takashi、Takagi Tomoharu、Yoshitani Junya、Ueno Takuro、Ueoka Ken、Tsuchiya Hiroyuki
  • Journal Title: Mod Rheumatol Volume: 印刷中 Issue: 6 Pages: 1029-1034
  • DOI: 10.1080/14397595.2018.1436119
  • Peer Reviewed
• [Journal Article] Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic (2018)
  • Author(s): Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM
  • Journal Title: Cell Cycle Volume: 印刷中 Issue: 6 Pages: 801-809
  • DOI: 10.1080/15384101.2018.1431596
  • Peer Reviewed / Open Access
• [Journal Article] A histological examination of spinal reconstruction using a frozen bone autograft (2018)
  • Author(s): Shinmura Kazuya、Murakami Hideki、Demura Satoru、Kato Satoshi、Yoshioka Katsuhito、Hayashi Hiroyuki、Inoue Kei、Ota Takashi、Yokogawa Noriaki、Ishii Takayoshi、Igarashi Takashi、Tsuchiya Hiroyuki
  • Journal Title: PLoS One Volume: 13 Issue: 1 Pages: e0191679-e0191679
  • DOI: 10.1371/journal.pone.0191679
  • NAID: 120006454994
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of the “grand-piano sign” for determining femoral rotational alignment in total knee arthroplasty (2018)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Taga Tadashi、Inoue Daisuke、Yamamoto Takashi、Takagi Tomoharu、Yoshitani Junya、Ueno Takuro、Tsuchiya Hiroyuki
  • Journal Title: Knee Volume: 25 Issue: 1 Pages: 15-24
  • DOI: 10.1016/j.knee.2017.11.008
  • Peer Reviewed
• [Journal Article] Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. (2018)
  • Author(s): Takeuchi A, Suwanpramote P, Yamamoto N, Shirai T, Hayashi K, Kimura H, Miwa S, Higuchi T, Abe K, Tsuchiya H.
  • Journal Title: J Surg Oncol. Volume: 印刷中 Issue: 6 Pages: 1232-1238
  • DOI: 10.1002/jso.24971
  • Peer Reviewed
• [Journal Article] Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma (2018)
  • Author(s): Igarashi K, Kawaguchi K, Li S, Han Q, Tan Y, Murakami T, Kiyuna T, Miyake K, Miyake M, Singh AS, Eckardt MA, Nelson SD, Russell TA, Dry SM, Li Y, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Singh SR, Eilber FC, Hoffman RM
  • Journal Title: Cancer Lett Volume: 417 Pages: 168-173
  • DOI: 10.1016/j.canlet.2017.12.028
  • Peer Reviewed
• [Journal Article] The Efficacy of Wide Resection for Musculoskeletal Metastatic Lesions of Renal Cell Carcinoma (2018)
  • Author(s): Higuchi T, Yamamoto N, Hayashi K, Takeuchi A, Kato S, Miwa S, Abe K, Taniguchi Y, Aiba H, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 38 Pages: 577-582
  • Peer Reviewed
• [Journal Article] Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase (2018)
  • Author(s): Igarashi K, Li S, Han Q, Tan Y, Kawaguchi K, Murakami T, Kiyuna T, Miyake K, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA, Russell TA, Eckardt MA, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Eilber FC, Hoffman RM
  • Journal Title: J Cell Biochem Volume: 119 Issue: 4 Pages: 3537-3544
  • DOI: 10.1002/jcb.26527
  • Peer Reviewed
• [Journal Article] Differences in range of motion with the same combined anteversion after total hip arthroplasty (2018)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Taga Tadashi、Hasegawa Kazuhiro、Inoue Daisuke、Yamamoto Takashi、Takagi Tomoharu、Yoshitani Junya、Ueno Takuro、Tsuchiya Hiroyuki
  • Journal Title: Int Orthop Volume: 印刷中 Issue: 5 Pages: 1021-1028
  • DOI: 10.1007/s00264-017-3653-5
  • Peer Reviewed
• [Journal Article] Incidental durotomy during total en bloc spondylectomy (2018)
  • Author(s): Yokogawa Noriaki、Murakami Hideki、Demura Satoru、Kato Satoshi、Yoshioka Katsuhito、Tsuchiya Hiroyuki
  • Journal Title: Spine J Volume: 18 Issue: 3 Pages: 381-386
  • DOI: 10.1016/j.spinee.2017.07.169
  • Peer Reviewed
• [Journal Article] Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model (2017)
  • Author(s): Igarashi K、Kawaguchi K、Kiyuna T、Miyake K、Miyake M、Li Y、Nelson SD、Dry SM、Singh AS、Elliott IA、Russell TA、Eckardt MA、Yamamoto N、Hayashi K、Kimura H、Miwa S、Tsuchiya H、Eilber FC、Hoffman RM
  • Journal Title: Oncotarget Volume: 9 Issue: 8 Pages: 7774-7781
  • DOI: 10.18632/oncotarget.22892
  • NAID: 120006454991
  • Peer Reviewed / Open Access
• [Journal Article] Current status of immunotherapy for sarcomas (2017)
  • Author(s): Miwa Shinji、Nishida Hideji、Tsuchiya Hiroyuki
  • Journal Title: Immunotherapy Volume: 9 Issue: 16 Pages: 1331-1338
  • DOI: 10.2217/imt-2017-0101
  • NAID: 120006454997
  • Peer Reviewed
• [Journal Article] Risk factors for postoperative deep infection in bone tumors (2017)
  • Author(s): Miwa Shinji、Shirai Toshiharu、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Tada Kaoru、Kajino Yoshitomo、Inatani Hiroyuki、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Tsuchiya Hiroyuki
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: e0187438-e0187438
  • DOI: 10.1371/journal.pone.0187438
  • NAID: 120006374163
  • Peer Reviewed / Open Access
• [Journal Article] Temozolomide combined with irinotecan caused regression in an adult pleomorphic rhabdomyosarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model (2017)
  • Author(s): Igarashi Kentaro、Kawaguchi Kei、Kiyuna Tasuku、Murakami Takashi、Miwa Shinji、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Singh Arun S.、Kimura Hiroaki、Hayashi Katsuhiro、Yamamoto Norio、Tsuchiya Hiroyuki、Eilber Fritz C.、Hoffman Robert M.
  • Journal Title: Oncotarget Volume: 8 Issue: 44 Pages: 75874-75880
  • DOI: 10.18632/oncotarget.16548
  • Peer Reviewed / Open Access
• [Journal Article] Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients (2017)
  • Author(s): Tsuda Yusuke、Ogura Koichi、Hakozaki Michiyuki、Kikuta Kazutaka、Ae Keisuke、Tsuchiya Hiroyuki、Iwata Shintaro、Ueda Takafumi、Kawano Hirotaka、Kawai Akira
  • Journal Title: Journal of Surgical Oncology Volume: 115 Issue: 6 Pages: 760
  • DOI: 10.1002/jso.24567
  • URL: https://pure.teikyo.jp/en/publications/eea8c1c8-bb77-4d88-875b-428c66277688
  • Peer Reviewed
• [Journal Article] The accuracy of the “projected surgical transepicondylar axis” relative to the “true surgical transepicondylar axis” in total knee arthroplasty (2017)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Kajino Yoshitomo、Taga Tadashi、Hasegawa Kazuhiro、Inoue Daisuke、Yamamoto Takashi、Takagi Tomoharu、Yoshitani Junya、Ueno Takuro、Ojima Tomohiro、Tsuchiya Hiroyuki
  • Journal Title: Knee Volume: 24 Issue: 6 Pages: 1428-1434
  • DOI: 10.1016/j.knee.2017.07.017
  • Peer Reviewed
• [Journal Article] A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology (2017)
  • Author(s): Igarashi Kentaro、Murakami Takashi、Kawaguchi Kei、Kiyuna Tasuku、Miyake Kentaro、Zhang Yong、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Yanagawa Jane、Russell Tara A.、Singh Arun S.、Tsuchiya Hiroyuki、Elliott Irmina、Eilber Fritz C.、Hoffman Robert M.
  • Journal Title: Oncotarget Volume: 8 Issue: 37 Pages: 62111-62119
  • DOI: 10.18632/oncotarget.19095
  • Peer Reviewed / Open Access
• [Journal Article] A novel anionic-phosphate-platinum complex effectively targets an undifferentiated pleomorphic sarcoma better than cisplatinum and doxorubicin in a patient-derived orthotopic xenograft (PDOX) (2017)
  • Author(s): Igarashi Kentaro、Kawaguchi Kei、Murakami Takashi、Kiyuna Tasuku、Miyake Kentaro、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Singh Arun S.、Miwa Shinji、Odani Akira、Eilber Fritz C.、Tsuchiya Hiroyuki、Hoffman Robert M.
  • Journal Title: Oncotarget Volume: 8 Issue: 38 Pages: 63353-63359
  • DOI: 10.18632/oncotarget.18806
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness and Safety of Needle Medial Collateral Ligament Pie-Crusting in Total Knee Arthroplasty: A Cadaveric Study. (2017)
  • Author(s): Ohmori T, Kabata T, Kajino Y, Takagi T, Tsuchiya H.
  • Journal Title: J Knee Surg. 2017 Volume: 5 Issue: 08 Pages: 1-1
  • DOI: 10.1055/s-0037-1606377
  • Peer Reviewed
• [Journal Article] Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase (2017)
  • Author(s): Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM
  • Journal Title: Anticancer Res Volume: 37 Pages: 4807-4812
  • Peer Reviewed
• [Journal Article] Two-dimensional motion analysis of dynamic knee valgus identifies female high school athletes at risk of non-contact anterior cruciate ligament injury (2017)
  • Author(s): Numata Hitoaki、Nakase Junsuke、Kitaoka Katsuhiko、Shima Yosuke、Oshima Takeshi、Takata Yasushi、Shimozaki Kengo、Tsuchiya Hiroyuki
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: 26 Issue: 2 Pages: 442-447
  • DOI: 10.1007/s00167-017-4681-9
  • Peer Reviewed
• [Journal Article] Spontaneous shrinkage of solitary osteochondromas (2017)
  • Author(s): Aiba Hisaki、Yamada Satoshi、Yamamoto Norio、Hayashi Katsuhiro、Miwa Shinji、Tsuchiya Hiroyuki、Otsuka Takanobu
  • Journal Title: Skeletal Radiol Volume: 47 Issue: 1 Pages: 61-68
  • DOI: 10.1007/s00256-017-2760-0
  • Peer Reviewed
• [Journal Article] Non-tuberculous Mycobacterium or Fungus Induced Chronic Tenosynovitis with Rice Body of the Hand (2017)
  • Author(s): Yamamoto D, Tada K, Suganuma S, Ikeda K, Tsuchiya H
  • Journal Title: J Hand Surg Asian Pac Vol Volume: 22 Pages: 337-342
  • Peer Reviewed
• [Journal Article] Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines (2017)
  • Author(s): Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh AS, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM
  • Journal Title: Anticancer Res Volume: 37 Pages: 4081-4084
  • Peer Reviewed
• [Journal Article] Knee joint preservation surgery in osteosarcoma using tumour-bearing bone treated with liquid nitrogen (2017)
  • Author(s): Higuchi Takashi、Yamamoto Norio、Nishida Hideji、Hayashi Katsuhiro、Takeuchi Akihiko、Kimura Hiroaki、Miwa Shinji、Inatani Hiroyuki、Shimozaki Shingo、Kato Takashi、Aoki Yu、Abe Kensaku、Taniguchi Yuta、Tsuchiya Hiroyuki
  • Journal Title: Int Orthop Volume: 41 Issue: 10 Pages: 2189-2197
  • DOI: 10.1007/s00264-017-3499-x
  • NAID: 120006343969
  • Peer Reviewed
• [Journal Article] Reliability of radiographic evaluations of the stage of osteoarthritis of the hip joint and an approach to improve the staging criteria (2017)
  • Author(s): Yoshitani Junya、Nakamura Takuya、Ueshima Kenichi、Ebara Hidehumi、Kabata Tamon、Tsuchiya Hiroyuki
  • Journal Title: J Orthop Sci Volume: 22 Issue: 5 Pages: 905-908
  • DOI: 10.1016/j.jos.2017.05.007
  • Peer Reviewed
• [Journal Article] Contribution of methylglyoxal to delayed healing of bone injury in diabetes (2017)
  • Author(s): Aikawa Takao、Matsubara Hidenori、Ugaji Shuhei、Shirakawa Junichi、Nagai Ryoji、Munesue Seiichi、Harashima Ai、Yamamoto Yasuhiko、Tsuchiya Hiroyuki
  • Journal Title: Molecular Medicine Reports Volume: 16 Issue: 1 Pages: 403-409
  • DOI: 10.3892/mmr.2017.6589
  • Peer Reviewed
• [Journal Article] An unusual case of proximal humeral simple bone cyst in an adult from secondary cystic change (2017)
  • Author(s): Rosario Mamer S.、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Kimura Hiroaki、Miwa Shinji、Higuchi Takashi、Inatani Hiroyuki、Abe Kensaku、Taniguchi Yuta、Aiba Hisaki、Tsuchiya Hiroyuki
  • Journal Title: World J Surg Oncol Volume: 15 Issue: 1 Pages: 102-102
  • DOI: 10.1186/s12957-017-1166-8
  • Peer Reviewed / Open Access
• [Journal Article] Intra-arterial administration of tumor-targeting Salmonella typhimurium A1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model (2017)
  • Author(s): Igarashi Kentaro、Kawaguchi Kei、Murakami Takashi、Kiyuna Tasuku、Miyake Kentaro、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Yanagawa Jane、Russell Tara A.、Singh Arun S.、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Tsuchiya Hiroyuki、Eilber Fritz C.、Hoffman Robert M.
  • Journal Title: Cell Cycle Volume: 16 Issue: 12 Pages: 1164-1170
  • DOI: 10.1080/15384101.2017.1317417
  • Peer Reviewed
• [Journal Article] Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy (2017)
  • Author(s): Yonezawa Noritaka、Murakami Hideki、Kato Satoshi、Takeuchi Akihiko、Tsuchiya Hiroyuki
  • Journal Title: Eur Spine J Volume: 26 Issue: S1 Pages: 236-242
  • DOI: 10.1007/s00586-017-5086-7
  • Peer Reviewed
• [Journal Article] Inhibition of biofilm formation on iodine-supported titanium implants (2017)
  • Author(s): Inoue Daisuke、Kabata Tamon、Ohtani Kaori、Kajino Yoshitomo、Shirai Toshiharu、Tsuchiya Hiroyuki
  • Journal Title: Int Orthop Volume: 41 Issue: 6 Pages: 1093-1099
  • DOI: 10.1007/s00264-017-3477-3
  • Peer Reviewed
• [Journal Article] Intercalary frozen autograft for reconstruction of malignant bone and soft tissue tumours (2017)
  • Author(s): Zekry Karem M.、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Alkhooly Ali Zein A. A.、Abd-Elfattah Ahmed Saleh、Fouly Ezzat H.、Ahmed Adel Refaat、Tsuchiya Hiroyuki
  • Journal Title: Int Orthop Volume: 41 Issue: 7 Pages: 1481-1487
  • DOI: 10.1007/s00264-017-3446-x
  • Peer Reviewed
• [Journal Article] The influence of surgical approach on postoperative pelvic tilt after total hip arthroplasty (2017)
  • Author(s): Inoue Daisuke、Kabata Tamon、Kajino Yoshitomo、Taga Tadashi、Hasegawa Kazuhiro、Yamamoto Takashi、Takagi Tomoharu、Ohmori Takaaki、Tsuchiya Hiroyuki
  • Journal Title: Eur J Orthop Surg Traumatol Volume: 27 Issue: 8 Pages: 1131-1138
  • DOI: 10.1007/s00590-017-1946-4
  • Peer Reviewed
• [Journal Article] Antimetastatic Efficacy of the Combination of Caffeine and Valproic Acid on an Orthotopic Human Osteosarcoma Cell Line Model in Nude Mice (2017)
  • Author(s): Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM
  • Journal Title: Anticancer Res Volume: 37 Pages: 1005-1011
  • Peer Reviewed
• [Journal Article] Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma. (2017)
  • Author(s): Miwa S, Nishida H, Tanzawa Y, Takeuchi A, Hayashi K, Yamamoto N, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H.
  • Journal Title: Cancer Volume: 123 Issue: 9 Pages: 1576-84
  • DOI: 10.1002/cncr.30606
  • Peer Reviewed
• [Journal Article] Innovative exercise device for the abdominal trunk muscles: An early validation study (2017)
  • Author(s): Kato Satoshi、Murakami Hideki、Inaki Anri、Mochizuki Takafumi、Demura Satoru、Nakase Junsuke、Yoshioka Katsuhito、Yokogawa Noriaki、Igarashi Takashi、Takahashi Naoki、Yonezawa Noritaka、Kinuya Seigo、Tsuchiya Hiroyuki
  • Journal Title: PLoS One Volume: 12 Issue: 2 Pages: e0172934-e0172934
  • DOI: 10.1371/journal.pone.0172934
  • Peer Reviewed / Open Access
• [Journal Article] Pathogenesis of Osteosclerotic Change Following Treatment with an Antibody Against RANKL for Giant Cell Tumour of the Bone (2017)
  • Author(s): Rosario M, Takeuchi A, Yamamoto N, Hayashi K, Miwa S, Higuchi T, Abe K, Taniguchi Y, Aiba H, Tanzawa Y, Murakami H, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 37 Pages: 749-754
  • Peer Reviewed
• [Journal Article] High Efficacy of Pazopanib on an Undifferentiated Spindle-Cell Sarcoma Resistant to First-Line Therapy Is Identified With a Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model (2017)
  • Author(s): Igarashi Kentaro、Kawaguchi Kei、Murakami Takashi、Kiyuna Tasuku、Miyake Kentaro、Singh Arun S.、Nelson Scott D.、Dry Sarah M.、Li Yunfeng、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Tsuchiya Hiroyuki、Eilber Fritz C.、Hoffman Robert M.
  • Journal Title: J Cell Biochem Volume: 118 Issue: 9 Pages: 2739-2743
  • DOI: 10.1002/jcb.25923
  • Peer Reviewed
• [Journal Article] Increase in Safe Zone Area of the Acetabular Cup Using Dual Mobility Cups in THA (2017)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Maeda Toru、Kajino Yoshitomo、Taga Tadashi、Hasegawa Kazuhiro、Inoue Daisuke、Yamamoto Takashi、Takagi Tomoharu、Tsuchiya Hiroyuki
  • Journal Title: Hip Int Volume: 27 Issue: 4 Pages: 361-367
  • DOI: 10.5301/hipint.5000466
  • Peer Reviewed
• [Journal Article] Selection of a Surgical Approach for Total Hip Arthroplasty According to the Depth to the Surgical Site (2017)
  • Author(s): Ohmori Takaaki、Kabata Tamon、Maeda Toru、Kajino Yoshitomo、Taga Tadashi、Hasegawa Kazuhiro、Inoue Daisuke、Yamamoto Takashi、Takagi Tomoharu、Tsuchiya Hiroyuki
  • Journal Title: Hip Int Volume: 27 Issue: 3 Pages: 273-280
  • DOI: 10.5301/hipint.5000463
  • Peer Reviewed
• [Journal Article] Do Mesenchymal Stem Cells Derived From Atypical Lipomatous Tumors Have Greater Differentiation Potency Than Cells From Normal Adipose Tissues? (2017)
  • Author(s): Inatani H, Yamamoto N, Hayashi K, Kimura H, Takeuchi A, Miwa S, Higuchi T, Abe K, Taniguchi Y, Yamada S, Asai K, Otsuka T, Tsuchiya H.
  • Journal Title: Clin Orthop Relat Res Volume: 印刷中 Issue: 6 Pages: 1693-1701
  • DOI: 10.1007/s11999-017-5259-z
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Functional and radiological outcomes of a minimally invasive surgical approach to monostotic fibrous dysplasia (2017)
  • Author(s): Rosario Mamer S.、Hayashi Katsuhiro、Yamamoto Norio、Takeuchi Akihiko、Miwa Shinji、Taniguchi Yuta、Tsuchiya Hiroyuki
  • Journal Title: World J Surg Oncol Volume: 15 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s12957-016-1068-1
  • Peer Reviewed / Open Access
• [Journal Article] Patient-derived orthotopic xenograft (PDOX) mouse model of adult rhabdomyosarcoma invades and recurs after resection in contrast to the subcutaneous ectopic model (2017)
  • Author(s): Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Miwa S, Nelson SD, Dry SM, Li Y, Singh A, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Eilber FC, Hoffman RM
  • Journal Title: Cell Cycle Volume: 16 Issue: 1 Pages: 91-94
  • DOI: 10.1080/15384101.2016.1252885
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Use of αv Integrin Linked to GFP to Image Molecular Dynamics in Trafficking Cancer-Cell Emboli (2017)
  • Author(s): Tome Y, Yano S, Sugimoto N, Mii S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: J Cell Biochem Volume: 118 Issue: 1 Pages: 26-30
  • DOI: 10.1002/jcb.25603
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Surgical management of proximal fibular tumors: A report of 12 cases (2016)
  • Author(s): Inatani H, Yamamoto N, Hayashi K, Kimura H, Takeuchi A, Miwa S, Higuchi T, Abe K, Taniguchi Y, Yamada S, Okamoto H, Otsuka T, Tsuchiya H
  • Journal Title: J Bone Oncol Volume: 5 Issue: 4 Pages: 163-166
  • DOI: 10.1016/j.jbo.2016.06.001
  • NAID: 120005982984
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Outcome of Reconstruction Using Frozen Autograft for a Humeral Bone Tumor (2016)
  • Author(s): Kimura H, Yamamoto N, Shirai T, Nishida H, Hayashi K, Tanzawa Y, Takeuchi A, Miwa S, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 36 Pages: 6631-6635
  • Peer Reviewed
• [Journal Article] The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ανβ3 integrin in chick embryo and nude mouse models (2016)
  • Author(s): Tome Y, Kimura H, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM
  • Journal Title: Oncotarget Volume: 7 Issue: 52 Pages: 87031-87036
  • DOI: 10.18632/oncotarget.13497
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin. (2016)
  • Author(s): Shimozaki S, Minamoto T, et al.
  • Journal Title: Oncotarget Volume: 7 Issue: 47 Pages: 77038-51
  • DOI: 10.18632/oncotarget.12781
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Non-toxic Efficacy of the Combination of Caffeine and Valproic Acid on Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models (2016)
  • Author(s): Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Kimura H, Miwa S, Hoffman RM, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 36 Pages: 4477-82
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of the Combination of a PARP Inhibitor and UVC on Cancer Cells as Imaged by Focus Formation by the DNA Repair-related Protein 53BP1 Linked to Green Fluorescent Protein (2016)
  • Author(s): Tome Y, Uehara F, Miwa S, Yano S, Mii S, Efimova EV, Bouvet M, Kimura H, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 36 Pages: 3821-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Use of αv Integrin Linked to Green Fluorescent Protein in Osteosarcoma Cells and Confocal Microscopy to Image Molecular Dynamics During Lung Metastasis in Nude Mice (2016)
  • Author(s): Tome Y, Yano S, Sugimoto N, Mii S, Uehara F, Miwa S, Bouvet M, Tsuchiya H, Kanaya F, Hoffman RM
  • Journal Title: Anticancer Res Volume: 36 Pages: 3811-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical outcome of recurrent giant cell tumor of the extremity in the era before molecular target therapy: the Japanese Musculoskeletal Oncology Group study (2016)
  • Author(s): Takeuchi A, Tsuchiya H, Ishii T, Nishida Y, Abe S, Matsumine A, Kawai A, Yoshimura K, Ueda T
  • Journal Title: BMC Musculoskelet Disord Volume: 17 Issue: 1 Pages: 306-306
  • DOI: 10.1186/s12891-016-1163-z
  • Peer Reviewed / Open Access
• [Journal Article] The impact of complete surgical resection of spinal metastases on the survival of patients with thyroid cancer (2016)
  • Author(s): Kato S, Murakami H, Demura S, Fujimaki Y, Yoshioka K, Yokogawa N, Tsuchiya H
  • Journal Title: Cancer Med Volume: 5 Issue: 9 Pages: 2343-9
  • DOI: 10.1002/cam4.823
  • Peer Reviewed / Open Access
• [Journal Article] Clinical relevance of peroxisome proliferator-activated receptor-gamma expression in myxoid liposarcoma (2016)
  • Author(s): Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Miwa S, Munesue S, Yamamoto Y, Tsuchiya H
  • Journal Title: BMC Cancer Volume: 16 Issue: 1 Pages: 442-442
  • DOI: 10.1186/s12885-016-2524-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro (2016)
  • Author(s): Tome Y, Kimura H, Kiyuna T, Sugimoto N, Tsuchiya H, Kanaya F, Bouvet M, Hoffman RM
  • Journal Title: Oncotarget Volume: 7 Issue: 29 Pages: 46315-46320
  • DOI: 10.18632/oncotarget.10111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Balancing Prolonged Survival with QoL Using Low-dose Pazopanib Maintenance: A Comparison with the PALETTE Study (2016)
  • Author(s): Abe K, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Inatani H, Higuchi T, Taniguchi Y, Tsuchiya H
  • Journal Title: Anticancer Res Volume: 36 Pages: 2893-7
  • Peer Reviewed
• [Journal Article] The outcomes of reconstruction using frozen autograft combined with iodine-coated implants for malignant bone tumors: compared with non-coated implants (2016)
  • Author(s): Shirai T, Tsuchiya H, Terauchi R, Tsuchida S, Mizoshiri N, Igarashi K, Miwa S, Takeuchi A, Kimura H, Hayashi K, Yamamoto N, Kubo T
  • Journal Title: Jpn J Clin Oncol Volume: 46 Issue: 8 Pages: 735-40
  • DOI: 10.1093/jjco/hyw065
  • NAID: 120005899104
  • Peer Reviewed
• [Journal Article] Tenosynovial giant cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant tumors: report of two cases (2016)
  • Author(s): Takeuchi A, Yamamoto N, Hayashi K, Miwa S, Takahira M, Fukui K, Oikawa T, Tsuchiya H
  • Journal Title: BMC Musculoskelet Disord Volume: 17 Issue: 1 Pages: 180-180
  • DOI: 10.1186/s12891-016-1050-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Real-time in vivo confocal fluorescence imaging of prostate cancer bone-marrow micrometastasis development at the cellular level in nude mice (2016)
  • Author(s): Miwa S, Toneri M, Igarashi K, Yano S, Kimura H, Hayashi K, Yamamoto N, Tsuchiya H, Hoffman RM
  • Journal Title: J Cell Biochem Volume: 117 Issue: 11 Pages: 2533-2537
  • DOI: 10.1002/jcb.25545
  • Peer Reviewed / Open Access
• [Journal Article] Spinal metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up (2016)
  • Author(s): Kato S, Murakami H, Demura S, Nambu K, Fujimaki Y, Yoshioka K, Kawahara N, Tomita K, Tsuchiya H
  • Journal Title: J Surg Oncol Volume: 113 Issue: 5 Pages: 587-92
  • DOI: 10.1002/jso.24186
  • Peer Reviewed
• [Journal Article] Fluorescence-guided surgery of human prostate cancer experimental bone metastasis in nude mice using anti-CEA DyLight 650 for tumor illumination. (2016)
  • Author(s): Miwa S, De Magalhaes N, Toneri M, Zhang Y, Cao W, Bouvet M, Tsuchiya H, Hoffman RM.
  • Journal Title: Journal of Orthopedic Research Volume: 34 Issue: 4 Pages: 559-65
  • DOI: 10.1002/jor.22973
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 骨軟部腫瘍に対する創外固定を用いた治療 (2017)
  • Author(s): 土屋弘行
  • Organizer: 第30回日本創外固定・骨延長学会
  • Invited
• [Presentation] Tumor reconstruction (2017)
  • Author(s): Hiroyuki Tsuchiya
  • Organizer: AAOS Specialty Day-LLRS (Limb Lengthening and Reconstruction Society)
  • Int'l Joint Research / Invited
• [Presentation] Iodine-Coating Technology (2017)
  • Author(s): Hiroyuki Tsuchiya
  • Organizer: The 19th General Meeting of ISOLS
  • Int'l Joint Research / Invited
• [Presentation] Joint-Sparing Surgery Using Frozen Tumor Autogarft (2017)
  • Author(s): Hiroyuki Tsuchiya
  • Organizer: The 19th General Meeting of ISOLS
  • Int'l Joint Research / Invited
• [Presentation] 骨軟部腫瘍に対する創外固定の応用 (2017)
  • Author(s): 土屋弘行
  • Organizer: 第90回日本整形外科学会学術総会
  • Invited
• [Presentation] 骨軟部腫瘍外科におけるカスタムメイドインプラントの課題と展望 (2017)
  • Author(s): 土屋弘行
  • Organizer: 第50回日本整形外科学会骨軟部腫瘍学術集会
  • Invited
• [Presentation] 骨再建術の進歩と骨再生促進の試み (2017)
  • Author(s): 土屋弘行
  • Organizer: 第32回日本整形外科学会基礎学術集会
  • Invited
• [Presentation] Distraction osteogenesis for bone infections (2017)
  • Author(s): Hiroyuki Tsuchiya
  • Organizer: 38th SICOT Orthopaedic World Congress
  • Int'l Joint Research / Invited
• [Presentation] Antimicrobial implants (iodine-coating) for bone infections (2017)
  • Author(s): Hiroyuki Tsuchiya
  • Organizer: 38th SICOT Orthopaedic World Congress
  • Int'l Joint Research / Invited
• [Presentation] 骨軟部腫瘍における手術とリハビリテーション (2016)
  • Author(s): 土屋弘行
  • Organizer: 第11回日本リハビリテーション医学会専門医会学術集会
  • Place of Presentation: 金沢市
  • Year and Date: 2016-10-29
  • Invited
• [Presentation] Treatment guidelines for musculoskeletal sarcoma in Japan (2016)
  • Author(s): Tsuchiya H
  • Organizer: 第54回日本癌治療学会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] Biological reconstruction using frozen tumor bone (2016)
  • Author(s): Tsuchiya H
  • Organizer: 第60回韓国整形外科学会
  • Place of Presentation: インチョン，韓国
  • Year and Date: 2016-10-19
  • Invited
• [Presentation] Correction of the deformity related to benign bone tumor (2016)
  • Author(s): Tsuchiya H
  • Organizer: 第60回韓国整形外科学会
  • Place of Presentation: インチョン，韓国
  • Year and Date: 2016-10-19
  • Invited
• [Presentation] Iodine-coated titanium plates, rods and ex fix pins (2016)
  • Author(s): Tsuchiya H
  • Organizer: 26th Annual Baltimore Deformity Course
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-08-26
  • Int'l Joint Research
• [Presentation] External fixation techniques in tumor surgery (2016)
  • Author(s): Tsuchiya H
  • Organizer: 26th Annual Baltimore Deformity Course
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2016-08-26
  • Int'l Joint Research
• [Presentation] 骨欠損に対する生物学的再建術ー未来に向けてー (2016)
  • Author(s): 土屋弘行
  • Organizer: 第89回日本整形外科学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-05-12
  • Invited
• [Presentation] Antimicrobial implant technology with iodine-coating (2016)
  • Author(s): Tsuchiya H
  • Organizer: X Congresso Brasileiro De Oncologia Ortopedica
  • Place of Presentation: Foz do Iguassu, Brazil
  • Year and Date: 2016-04-20
  • Int'l Joint Research
• [Presentation] Frozen autograft reconstruction (2016)
  • Author(s): Tsuchiya H
  • Organizer: X Congresso Brasileiro De Oncologia Ortopedica
  • Place of Presentation: Foz do Iguassu, Brazil
  • Year and Date: 2016-04-20
  • Int'l Joint Research
• [Presentation] Correction of tumor-related deformities (2016)
  • Author(s): Tsuchiya H
  • Organizer: X Congresso Brasileiro De Oncologia Ortopedica
  • Place of Presentation: Foz do Iguassu, Brazil
  • Year and Date: 2016-04-20
  • Int'l Joint Research
• [Presentation] 難治例に対する四肢再建術の進歩－創外固定からインプラントまで－ (2016)
  • Author(s): 土屋弘行
  • Organizer: 第8回南北合同東京整形外科医療連携フォーラム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 骨軟部腫瘍に対する患肢温存手術とリハビリテーション (2016)
  • Author(s): 土屋弘行
  • Organizer: 第53回日本リハビリテーション医学会学術集会
  • Place of Presentation: 京都市
  • Invited
• [Presentation] 整形外科医の夢・挑戦・実現（Dream, Dare and Do.）ー“かがやき”をはなてるか？ (2016)
  • Author(s): 土屋弘行
  • Organizer: 第５回JASA(Japan Association of Spine Surgeons with Ambition)
  • Place of Presentation: 金沢市
  • Invited
• [Presentation] Orthopaedic hardware modifications for osteomyelitis (2016)
  • Author(s): Tsuchiya H
  • Organizer: 26th Annual Baltimore Limb Deformity Pre-course Masters of Disaster: Managing Osteomyelitis in the 21st Century
  • Place of Presentation: Baltimore, USA
  • Int'l Joint Research
• [Presentation] Cierny-Mader Stage 3 tibial osteomyelitis (2016)
  • Author(s): Tsuchiya H
  • Organizer: 26th Annual Baltimore Limb Deformity Pre-course Masters of Disaster: Managing Osteomyelitis in the 21st Century
  • Place of Presentation: Baltimore, USA
  • Int'l Joint Research
• [Presentation] Case presentation-Femoral infected non-union (2016)
  • Author(s): Tsuchiya H
  • Organizer: 26th Annual Baltimore Limb Deformity Pre-course Masters of Disaster: Managing Osteomyelitis in the 21st Century
  • Place of Presentation: Baltimore, USA
  • Int'l Joint Research
• [Presentation] 金沢発整形外科医療の最前線 (2016)
  • Author(s): 土屋弘行
  • Organizer: 第158回神奈川整形外科災害外科研究会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 難治例に対する四肢再建術の進歩 (2016)
  • Author(s): 土屋弘行
  • Organizer: 北海道大学第15回MOS会
  • Place of Presentation: 札幌市
  • Invited
• [Presentation] 四肢再建術の進歩－創外固定からインプラントまで－ (2016)
  • Author(s): 土屋弘行
  • Organizer: 第6回徳島運動器疾患の疼痛を考える会
  • Place of Presentation: 徳島市
  • Invited
• [Book] Management of juxtaphyseal malignant bone tumors around the knee joint: New concepts in limb-sparing surgery. In Pediatric Lower Limb Deformities-principles and techniques of management, Sabharwal S ed. (2016)
  • Author(s): Matsubara H & Tsuchiya H
  • Total Pages: 10
  • Publisher: Springer Cham Heidelberg, New York Dordrecht London