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Identification of the cell-of-origin of ectopic bones using lineage tracing mice

Research Project

Project/Area Number 16K15662
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

Ikeya Makoto  京都大学, iPS細胞研究所, 准教授 (20442923)

Co-Investigator(Renkei-kenkyūsha) YAMADA Yasuhiro  京都大学, iPS細胞研究所, 教授 (70313872)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords異所性骨化 / 細胞・組織 / 進行性骨化性線維異形成症
Outline of Final Research Achievements

Fibrodysplasia Ossificans Progressiva (hereafter refer as FOP) is an intractable rare disease. In FOP patients, ectopic bones gradually appears in connective tissues such as muscles, tendons, and ligaments, and the cell-of-origin the ectopic bones were not clear. In this application, we hypothesized that neural crest cells are one of the origins of ectopic bone of FOP. By using genetically modified lineage tracing mice, we have succeeded to obtain an preliminary results that support this hypothesis.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2023-12-25  

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