Calcium homeostasis regulation by intestinal mechano-stress sensor

• Project/Area Number: 16K15665
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: Maruyama Kenta 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (60724119)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 骨代謝 / メカノストレス / 腸管上皮 / カルシウム / メカノセンサー

Outline of Final Research Achievements

The mechano-stress sensor X (alias) is expressed in intestinal epithelium. Deletion of mechano-stress sensor X in the intestinal epithelium leads to increased bone volume. This result suggests that intestinal mechano-stress sensor activation suppresses bone formation. The novel gut-bone homeostasis machinery is now under investigation.

Research Products

• [Journal Article] Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. (2017)
  • Author(s): Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 114 Issue: 35
  • DOI: 10.1073/pnas.1708598114
  • Peer Reviewed / Open Access
• [Journal Article] Nociceptors Boost the Resolution of Fungal Osteoinflammation via the TRP Channel-CGRP-Jdp2 Axis (2017)
  • Author(s): Maruyama Kenta、Takayama Yasunori、Kondo Takeshi、Ishibashi Ken-ichi、Sahoo Bikash Ranjan、Kanemaru Hisashi、Kumagai Yutaro、Martino Mika?l M.、Tanaka Hiroki、Ohno Naohito、Iwakura Yoichiro、Takemura Naoki、Tominaga Makoto、Akira Shizuo
  • Journal Title: Cell Reports Volume: 19 Issue: 13 Pages: 2730-2742
  • DOI: 10.1016/j.celrep.2017.06.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Plasmodium products persist in the bone marrow and promote chronic bone loss (2017)
  • Author(s): Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin JW, Khan SM, Kuroda E, Akira S, Ishii KJ, Coban C.
  • Journal Title: Science Immunology Volume: 2 Issue: 12 Pages: 2-2
  • DOI: 10.1126/sciimmunol.aam8093
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanistic and structual basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity (2017)
  • Author(s): Bikash R. Sahoo, Kenta Maruyama, Jyotheeswara R. Edula, Takahiro Tougan, Yuxi Lin, Young-Ho Lee, Toshihiro Horii, and Toshimichi Fujiwara
  • Journal Title: Scientific Reports Volume: 7:44781 Issue: 1 Pages: 44781-44796
  • DOI: 10.1038/srep44781
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Netrins as Prophylactic Targets of Skeletal diseases: A Double-Edged Sword? (2017)
  • Author(s): *Kenta Maruyama, Naoki Takemura, Mikael M. Martino, Takeshi Kondo, and Shizuo Akira.
  • Journal Title: Pharmacological Research Volume: 122 Pages: 46-52
  • DOI: 10.1016/j.phrs.2017.05.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bone-protective Functions of Netrin 1 Protein (2016)
  • Author(s): Kenta Maruyama, Takahiko Kawasaki, Masahide Hamaguchi, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Naoki Takemura, Thangaraj Karuppuchamy, Takeshi Kondo, Takumi Kawasaki, Masahiro Fukusaka, Takuma Misawa, Tatsuya Saitoh, Yutaka Suzuki, Mikael M Martino, Yutaro Kumagai, and Shizuo Akira
  • Journal Title: Journal of Biological Chemistry Volume: 291 Issue: 46 Pages: 23854-23868
  • DOI: 10.1074/jbc.m116.738518
  • Peer Reviewed
• [Presentation] 真菌感染随伴症状とATP (2018)
  • Author(s): 丸山健太
  • Organizer: 第138回 日本薬学会 一般シンポジウム“次世代のプリン作動性化学伝達遮断薬の創成を目指して
  • Invited
• [Presentation] 真菌感染随伴疼痛の生物学的意義とは？ (2017)
  • Author(s): 丸山健太
  • Organizer: 第59回 歯科基礎医学会学術大会アップデートシンポジウム
  • Invited
• [Book] 実験医学 2017年12月号 Vol.35 No.19、「Type2サイトカインによる感覚神経の直接刺激が痒みを増悪させる」 (2017)
  • Author(s): 丸山健太
  • Total Pages: 137
  • Publisher: 羊土社
  • ISBN: 9784758125024
• [Patent(Industrial Property Rights)] 真菌感染における宿主応答抑制剤 (2017)
  • Inventor(s): 丸山健太、森山芳則、野村政壽
  • Industrial Property Rights Holder: 丸山健太、森山芳則、野村政壽
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-134071
  • Filing Date: 2017