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The study to develop a therapeutic method for PTSD with opiate

Research Project

Project/Area Number 16K15679
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionYokohama City University

Principal Investigator

Miyazaki Tomoyuki  横浜市立大学, 医学部, 准教授 (30580724)

Co-Investigator(Renkei-kenkyūsha) TAKASE Kenkichi  自治医科大学, 医学部, 教授 (80381474)
Research Collaborator KOBAYASHI Ayako  横浜市立大学, 医学部, 指導診療医
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsオピオイド / AMPA受容体 / PTSD / 恐怖学習 / ラット / AMPA
Outline of Final Research Achievements

A ultra-short acting opiate, remifentanil, promoted the dephospholyration of hippocampal AMPA receptors in a dose-dependent manner, leading to the reduction of membrane AMPA receptors. Furthermore, this phenomenon was mediated by protein phosphatase1. In vivo manipulation to promote the dephospholyration of hippocampal AMPA receptors could erase fear memory in the rats.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-01-27  

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