| Project/Area Number |
16K15679
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKASE Kenkichi 自治医科大学, 医学部, 教授 (80381474)
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| Research Collaborator |
KOBAYASHI Ayako 横浜市立大学, 医学部, 指導診療医
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | オピオイド / AMPA受容体 / PTSD / 恐怖学習 / ラット / AMPA |
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| Outline of Final Research Achievements |
A ultra-short acting opiate, remifentanil, promoted the dephospholyration of hippocampal AMPA receptors in a dose-dependent manner, leading to the reduction of membrane AMPA receptors. Furthermore, this phenomenon was mediated by protein phosphatase1. In vivo manipulation to promote the dephospholyration of hippocampal AMPA receptors could erase fear memory in the rats.
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