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The development of confocal laser endomicroscopy for treatment of bladder carcinoma in situ

Research Project

Project/Area Number 16K15694
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Oishi Masakatsu  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (90405316)

Co-Investigator(Kenkyū-buntansha) 上田 崇  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (50601598)
浮村 理  京都府立医科大学, 医学(系)研究科(研究院), 教授 (70275220)
岡 潔  国立研究開発法人量子科学技術研究開発機構, 関西光科学研究所 量子生命科学研究部, 上席研究員(定常) (80354661)
納谷 佳男  明治国際医療大学, 医学教育研究センター, 客員教授 (80639881)
高羽 夏樹  明治国際医療大学, 医学教育研究センター, 准教授 (80294081)
本郷 文弥  京都府立医科大学, 医学(系)研究科(研究院), 講師 (80291798)
牛嶋 壮  京都府立医科大学, 医学部附属病院, 研究員 (10398373)
藤原 敦子  京都府立医科大学, 医学(系)研究科(研究院), 助教 (20457980)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords膀胱上皮内癌 / 光力学的診断 / 複合型光ファイバー / 複合型レーザーファイバー / 尿路上皮癌内視鏡診断 / レーザー顕微内視鏡 / 尿路上皮癌 / 光力学的治療 / レーザーファイバー開発
Outline of Final Research Achievements

We did basic and clinical research about probe-based confocal laser endomicroscopy (pCLE) with acrinol, and observed the nuclei of urothelial carcinoma cells in situ that were not visible with cystoscopy under white light using pCLE with acrinol.
However, the detection of material for diode laser did not go smoothly. Therefore, we are going to use pCLE and need to downsize pCLE.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] Probe-based confocal laser endomicroscopy using acrinol as a novel dye can be used to visualize cancer nuclei of bladder carcinoma in situ2018

    • Author(s)
      Yoshio Naya, Natsuki Takaha, Takako Okubo, et al.
    • Journal Title

      J Endourol Case Rep.

      Volume: 1 Issue: 1 Pages: 25-27

    • DOI

      10.1089/cren.2017.0114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of urological cancer morphology by using probe-based confocal laser endomicroscopy with new contrast agent-preliminary study for new TURBT technique.2017

    • Author(s)
      Naya Y, Konishi E, Takaha N, et al.
    • Journal Title

      JSM Clin Oncol Res

      Volume: 5 Pages: 1051-1053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of Urological Cancer Morphology by Using Probe-Based Confocal Laser Endomicroscopy with New Contrast Agent-Preliminary Study for New TURBT Technique2017

    • Author(s)
      Yoshio Naya, Eiichi Konishi, Natsuki Takaha, Masakatsu Oishi, Takashi Ueda, Fumiya Hongo, Tsuneharu Miki, and Osamu Ukimura
    • Journal Title

      JSM Clinical Oncology and Research

      Volume: 5 Pages: 1051-1051

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 尿路上皮癌診断に対する新しい蛍光造影剤を用いた共焦点レーザー顕微内視鏡の有用性についての検討ー摘出組織での検討ー2017

    • Author(s)
      納谷 佳男
    • Organizer
      第105回日本泌尿器科学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2017-04-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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