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Acquired tolerance during pregnency, a challenge towards the application to oncology/transplantation

Research Project

Project/Area Number 16K15699
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionAkita University

Principal Investigator

TERADA YUKIHIRO  秋田大学, 医学(系)研究科(研究院), 教授 (10260431)

Co-Investigator(Kenkyū-buntansha) 佐藤 直樹  秋田大学, 医学(系)研究科(研究院), 准教授 (40447199)
清水 大  秋田大学, 医学部, 講師 (60400503)
佐藤 敏治  秋田大学, 医学(系)研究科(研究院), 助教 (70636183)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsマイクロキメリズム / 免疫寛容機構 / キメラ / 免疫学的異系移植 / in vivo
Outline of Final Research Achievements

Pruduction of animal model is the fundamental process of this challenge.We collected information from bio/oncology conference and bio/reproductive conference for two years and continue a traial, but did not come to obtain stable system.However, we obtained the finding about some gynecologic tumors which were derived form this challenge.
The origin of mature cystic teratoma is parthenogenesis of the ovum,and , It is extremely frequent ovarian tumor clinically.We perform microarray analysis in the tissue from young teratoma patients, that repeated a disease, and a comparison with the normal tissue.It is consisting clearly that a gene associated with the ovum activation of the tumor is different from a normal group.Furthermore, we are going to proceed with analysis about those microchimeric expression degree in the tumor.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Cesarean section rates and local resources for perinatal care in Japan: A nationwide ecological study using the national database of health insurance claims.2018

    • Author(s)
      Maeda Eri, Ishihara Osamu,Tomio Jun,Sato Aya,Terada Ykihiro,Kobayashi Yasuki,Murata Katsuyuki
    • Journal Title

      Obstetrics and Gynecology Research

      Volume: 44 Issue: 2 Pages: 208-216

    • DOI

      10.1111/jog.13518

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leaflets and continual educational offerings led to increased coverage rate of newborn hearing screening in Akita.2018

    • Author(s)
      Sato Teruyuki,Nakazawa Misao,Takahashi Shin,Mizuno Tomomi,Sato Akira,Noguchi Atsuko,Sato Megumi,Katagiri Sadako,Yamada Takechiyo
    • Journal Title

      Auris Nasus Larynx

      Volume: 45 Issue: 4 Pages: 673-679

    • DOI

      10.1016/j.anl.2017.11.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The location of “8”-shaped hatching influences inner cell mass formation in mouse blastocysts.2017

    • Author(s)
      Yohei Onodera, Kazumasa Takahashi, Mayumi Goto, Mibuki Anzai, Natsuki Ono, Hiromitsu Shirasawa, Wataru Sato, Hiroshi Miura, Naoki Sato, Akira Sato, Yukiyo Kumazawa, Yukihiro Terada
    • Journal Title

      PLoS ONE

      Volume: 12 Issue: 4 Pages: e0175150-e0175150

    • DOI

      10.1371/journal.pone.0175150

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Food intake affects sperm-egg fusion through the GIP/PSG17 axis in mice.2017

    • Author(s)
      Tatsunori Shimizu, Takehiro Sato, Katsushi Tsukiyama, Hiroki Fujita, Shunsuke Kato, Manabu Hoizumi, Hiromitsu Shirasawa, Takuma Narita, Yukihiro Terada, Yutaka Seino, Yoichiro Yamada
    • Journal Title

      Endocrinology

      Volume: - Issue: 7 Pages: 2134-2144

    • DOI

      10.1210/en.2016-1861

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women.2017

    • Author(s)
      Tanaka H,Shirasawa H,Shimizu D,Sato N,Ooyama N,Takahashi O,Terada Y
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Pages: 1597-1601

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro maturation of human immature oocytes for fertility preservation and research material2017

    • Author(s)
      Shirasawa Hiromitsu、Terada Yukihiro
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 16 Issue: 3 Pages: 258-267

    • DOI

      10.1002/rmb2.12042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer2017

    • Author(s)
      Takahashi K,Sato N,Sugawara T,Kato A,Sato T,Shimizu D,Tamura D,Kito M,Makino K,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Terada Y
    • Journal Title

      Gynecologic Oncology

      Volume: 147 Issue: 2 Pages: 388-395

    • DOI

      10.1016/j.ygyno.2017.08.016

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of placental site trophoblastic tumor complicated nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis.2017

    • Author(s)
      Sato W,Miura Y,Shirasawa H,Kumazawa Y,Kumagai J,Terada Y
    • Journal Title

      Gynecology and Minimally Invasive Therapy

      Volume: 6 Pages: 69-72

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮体癌におけるリンチ症候群のスクリーニング戦略.2017

    • Author(s)
      菅原多恵,佐藤直樹,加藤彩,髙橋和江,清水大,佐藤敏治,牧野健一,木藤正彦,田村大輔,寺田幸弘
    • Journal Title

      日本家族性腫瘍学会誌

      Volume: 16 Pages: 44-49

    • NAID

      130005665563

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients.2016

    • Author(s)
      Kato A,Sato N,Sugawara T,Takahashi K,Kito M,Makino K,Sato T,Shimizu D,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Kumagai J,Terada Y
    • Journal Title

      Am J Surg Pathol

      Volume: 40 Issue: 6 Pages: 770-776

    • DOI

      10.1097/pas.0000000000000606

    • NAID

      120006364339

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cesarean scar caseating granuloma: A case of vesicouterine fistula 30 years after cesarean section.2016

    • Author(s)
      Sato T,Sato N,Takahashi K,Kito M,Sugawara T,Kato A,Makino K,Shimizu D,Terada Y
    • Journal Title

      Clinical Case Reports

      Volume: 4 Issue: 8 Pages: 721-724

    • DOI

      10.1002/ccr3.607

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube.2016

    • Author(s)
      Kito M,Maeda D,Kudo Y,Sato N,Shih M,Wang L,Tanaka M,Terada Y,Goto A
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 7 Pages: e0160136-e0160136

    • DOI

      10.1371/journal.pone.0160136

    • NAID

      120007089065

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of PSTT complicated nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis.2016

    • Author(s)
      Sato W,Miura Y,Shirasawa H,Kumazawa Y,Kumagai J,Terada Y
    • Journal Title

      Gynecology and Minimally Invasive Therapy,

      Volume: 21 Pages: 17-19

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] MED12 Mutationin UterineAdenomyoma.2017

    • Author(s)
      Kito,M.,Maeda,D.,Terada,Y.,Goto,A
    • Organizer
      The United States & Canadian Academy of Pathology’s 106th Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Uterine Adenomatoid Tumor: A Neoplasm Having Frequent Association With Immunosuppressive Therapy.2017

    • Author(s)
      Tamura,D
    • Organizer
      The 5th Biennial Meeting of Asian Society of Gynecologic Oncology(ASGO2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 臨床進行期Ⅰ期の卵巣粘液癌における後腹膜リンパ節郭清の省略条件.2016

    • Author(s)
      佐藤敏治,佐藤直樹,髙橋和江,木藤正彦,牧野健一,清水大,寺田幸弘
    • Organizer
      第68回日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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