Acquired tolerance during pregnency, a challenge towards the application to oncology/transplantation

• Project/Area Number: 16K15699
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Akita University
• Principal Investigator: TERADA YUKIHIRO 秋田大学, 医学(系)研究科(研究院), 教授 (10260431)
• Co-Investigator(Kenkyū-buntansha): 佐藤 直樹 秋田大学, 医学(系)研究科(研究院), 准教授 (40447199) ; 清水 大 秋田大学, 医学部, 講師 (60400503) ; 佐藤 敏治 秋田大学, 医学(系)研究科(研究院), 助教 (70636183)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: マイクロキメリズム / 免疫寛容機構 / キメラ / 免疫学的異系移植 / in vivo

Outline of Final Research Achievements

Pruduction of animal model is the fundamental process of this challenge.We collected information from bio/oncology conference and bio/reproductive conference for two years and continue a traial, but did not come to obtain stable system.However, we obtained the finding about some gynecologic tumors which were derived form this challenge.
The origin of mature cystic teratoma is parthenogenesis of the ovum,and , It is extremely frequent ovarian tumor clinically.We perform microarray analysis in the tissue from young teratoma patients, that repeated a disease, and a comparison with the normal tissue.It is consisting clearly that a gene associated with the ovum activation of the tumor is different from a normal group.Furthermore, we are going to proceed with analysis about those microchimeric expression degree in the tumor.

Research Products

• [Journal Article] Cesarean section rates and local resources for perinatal care in Japan: A nationwide ecological study using the national database of health insurance claims. (2018)
  • Author(s): Maeda Eri, Ishihara Osamu,Tomio Jun,Sato Aya,Terada Ykihiro,Kobayashi Yasuki,Murata Katsuyuki
  • Journal Title: Obstetrics and Gynecology Research Volume: 44 Issue: 2 Pages: 208-216
  • DOI: 10.1111/jog.13518
  • Peer Reviewed / Open Access
• [Journal Article] Leaflets and continual educational offerings led to increased coverage rate of newborn hearing screening in Akita. (2018)
  • Author(s): Sato Teruyuki,Nakazawa Misao,Takahashi Shin,Mizuno Tomomi,Sato Akira,Noguchi Atsuko,Sato Megumi,Katagiri Sadako,Yamada Takechiyo
  • Journal Title: Auris Nasus Larynx Volume: 45 Issue: 4 Pages: 673-679
  • DOI: 10.1016/j.anl.2017.11.014
  • Peer Reviewed / Open Access
• [Journal Article] The location of “8”-shaped hatching influences inner cell mass formation in mouse blastocysts. (2017)
  • Author(s): Yohei Onodera, Kazumasa Takahashi, Mayumi Goto, Mibuki Anzai, Natsuki Ono, Hiromitsu Shirasawa, Wataru Sato, Hiroshi Miura, Naoki Sato, Akira Sato, Yukiyo Kumazawa, Yukihiro Terada
  • Journal Title: PLoS ONE Volume: 12 Issue: 4 Pages: e0175150-e0175150
  • DOI: 10.1371/journal.pone.0175150
  • Peer Reviewed / Open Access
• [Journal Article] Food intake affects sperm-egg fusion through the GIP/PSG17 axis in mice. (2017)
  • Author(s): Tatsunori Shimizu, Takehiro Sato, Katsushi Tsukiyama, Hiroki Fujita, Shunsuke Kato, Manabu Hoizumi, Hiromitsu Shirasawa, Takuma Narita, Yukihiro Terada, Yutaka Seino, Yoichiro Yamada
  • Journal Title: Endocrinology Volume: - Issue: 7 Pages: 2134-2144
  • DOI: 10.1210/en.2016-1861
  • Peer Reviewed / Open Access
• [Journal Article] Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women. (2017)
  • Author(s): Tanaka H,Shirasawa H,Shimizu D,Sato N,Ooyama N,Takahashi O,Terada Y
  • Journal Title: J Obstet Gynaecol Res Volume: 43 Pages: 1597-1601
  • Peer Reviewed / Open Access
• [Journal Article] In vitro maturation of human immature oocytes for fertility preservation and research material (2017)
  • Author(s): Shirasawa Hiromitsu、Terada Yukihiro
  • Journal Title: Reproductive Medicine and Biology Volume: 16 Issue: 3 Pages: 258-267
  • DOI: 10.1002/rmb2.12042
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of Lynch-like cases collaterally classified by Lynch syndrome identification strategy using universal screening in endometrial cancer (2017)
  • Author(s): Takahashi K,Sato N,Sugawara T,Kato A,Sato T,Shimizu D,Tamura D,Kito M,Makino K,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Terada Y
  • Journal Title: Gynecologic Oncology Volume: 147 Issue: 2 Pages: 388-395
  • DOI: 10.1016/j.ygyno.2017.08.016
  • Peer Reviewed / Open Access
• [Journal Article] A case of placental site trophoblastic tumor complicated nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis. (2017)
  • Author(s): Sato W,Miura Y,Shirasawa H,Kumazawa Y,Kumagai J,Terada Y
  • Journal Title: Gynecology and Minimally Invasive Therapy Volume: 6 Pages: 69-72
  • Peer Reviewed
• [Journal Article] 子宮体癌におけるリンチ症候群のスクリーニング戦略. (2017)
  • Author(s): 菅原多恵，佐藤直樹，加藤彩，髙橋和江，清水大，佐藤敏治，牧野健一，木藤正彦，田村大輔，寺田幸弘
  • Journal Title: 日本家族性腫瘍学会誌 Volume: 16 Pages: 44-49
  • NAID: 130005665563
  • Peer Reviewed
• [Journal Article] Isolated Loss of PMS2 Immunohistochemical Expression is Frequently Caused by Heterogenous MLH1 Promoter Hypermethylation in Lynch Syndrome Screening for Endometrial Cancer Patients. (2016)
  • Author(s): Kato A,Sato N,Sugawara T,Takahashi K,Kito M,Makino K,Sato T,Shimizu D,Shirasawa H,Miura H,Sato W,Kumazawa Y,Sato A,Kumagai J,Terada Y
  • Journal Title: Am J Surg Pathol Volume: 40 Issue: 6 Pages: 770-776
  • DOI: 10.1097/pas.0000000000000606
  • NAID: 120006364339
  • Peer Reviewed / Open Access
• [Journal Article] Cesarean scar caseating granuloma: A case of vesicouterine fistula 30 years after cesarean section. (2016)
  • Author(s): Ｓato T,Sato N,Takahashi K,Kito M,Sugawara T,Kato A,Makino K,Shimizu D,Terada Y
  • Journal Title: Clinical Case Reports Volume: 4 Issue: 8 Pages: 721-724
  • DOI: 10.1002/ccr3.607
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube. (2016)
  • Author(s): Kito M,Maeda D,Kudo Y,Sato N,Shih M,Wang L,Tanaka M,Terada Y,Goto A
  • Journal Title: PLoS ONE Volume: 11 Issue: 7 Pages: e0160136-e0160136
  • DOI: 10.1371/journal.pone.0160136
  • NAID: 120007089065
  • Peer Reviewed / Open Access
• [Journal Article] A case of PSTT complicated nephrotic syndrome in which hysteroscopic biopsy did not yield a definitive diagnosis. (2016)
  • Author(s): Sato W,Miura Y,Shirasawa H,Kumazawa Y,Kumagai J,Terada Y
  • Journal Title: Gynecology and Minimally Invasive Therapy, Volume: 21 Pages: 17-19
  • Peer Reviewed
• [Presentation] MED12 Mutationin UterineAdenomyoma. (2017)
  • Author(s): Kito,M.,Maeda,D.,Terada,Y.,Goto,A
  • Organizer: The United States & Canadian Academy of Pathology’s 106th Annual Meeting
  • Int'l Joint Research
• [Presentation] Uterine Adenomatoid Tumor: A Neoplasm Having Frequent Association With Immunosuppressive Therapy. (2017)
  • Author(s): Tamura,D
  • Organizer: The 5th Biennial Meeting of Asian Society of Gynecologic Oncology（ASGO2017）
  • Int'l Joint Research
• [Presentation] 臨床進行期Ⅰ期の卵巣粘液癌における後腹膜リンパ節郭清の省略条件． (2016)
  • Author(s): 佐藤敏治，佐藤直樹，髙橋和江，木藤正彦，牧野健一，清水大，寺田幸弘
  • Organizer: 第68回日本産科婦人科学会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2016-04-21