| Project/Area Number |
16K15707
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Kindai University (2017)
Kyoto University (2016) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
安彦 郁 京都大学, 医学(系)研究科(研究院), その他 (20508246)
越山 雅文 京都大学, 医学研究科, 客員研究員 (50724390)
小西 郁生 京都大学, 医学研究科, 名誉教授 (90192062)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 卵巣癌 / 食品 / 動物性タンパク質 / 植物性タンパク質 / 癌 |
|---|
| Outline of Final Research Achievements |
We evaluated whether different dietary protein qualities (isocaloric diets involving animal or plant protein) could inhibit the ovarian cancer growth in mice. In the mice of the 20% plant protein group, the ovarian cancer growth was reduced in comparison to the mice in the 20% animal protein group. The serum levels of insulin and IGF-1 levels were both lower in the mice of the 20% plant protein group than in the mice of the 20% animal protein group. Immunohistochemistry revealed that the level of p-4EBP1 (one of the major downstream effectors of the mTOR pathway) of the plant protein group was weaker than that of the animal protein group. Our findings suggest that a diet high in plant protein reduces the growth of human ovarian cancer cells in mice compared to a diet high in animal protein, possibly through the lack of activation of the IGF/Akt/mTOR pathway.
|
