Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesis
Project/Area Number |
16K15714
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
Principal Investigator |
YAMADA Hidekazu 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (10254012)
|
Co-Investigator(Kenkyū-buntansha) |
島 礼 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
伊藤 しげみ 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 卵巣がん / プロテインホスファターゼ / 婦人科腫瘍学 |
Outline of Final Research Achievements |
In order to address the function of protein phosphatase 6 (PP6) loss on K-ras-initiated tumorigenesis in ovary. To do so, we developed tamoxifen-inducible K-rasG12D-expressing mice and double mutant (K-rasG12D-expressing and Ppp6c-deficient) mice in which K-rasG12D expression is driven by the cytokeratin 14 (K14) promoter. Using 8week old and 12 weeks old female mice, intrabursal injection of an adenovirus-Cre construct was conducted. Eight month after the induction, mice were dissected and ovary was examined. Both K-rasG12D-expressing mice and doubly-mutant mice showed no tumors in the ovary. The results showed that K-rasG12D expression using this system is not sufficient to develop ovarian tumors in mice.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018
Author(s)
Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
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Journal Title
Cancer Science
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey2017
Author(s)
Tokunaga H, Takahashi F, Yamamoto H, Honda T, Watanabe T, Shoji T, Sugiyama T, Yamada H, Tando T, Yoshinaga K, Kagabu S, Otsuki T, Kin S, Yokoyama Y, Wagatsuma S, Sato K, Sato H, Oishi T, Yoshida Y, Hayasaka T, Matsui T, Imai N, Nishigori H, Shimokawa H, Yaegashi N, Watanabe Y.
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Journal Title
International Journal of Clinical Oncology
Volume: 22
Issue: 3
Pages: 541-547
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical efficacy of nedaplatin based concurrent chemoradiotherapy for uterine cervical cancer2016
Author(s)
Kagabu M, Shoji T , Murakami K, Omi H, Honda T, Miura F, Yokoyama Y, Tokunaga H,Takano T, Ohta T , Shimizu D & Sato N, Soeda S , Watanabe T, Yamada H, Mizunuma H, Yaegashi N Nagase S,Tase T, Sugiyama T
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Journal Title
a Tohoku Gynecologic Cancer Unit Study. Int J Clin Oncol
Volume: 21(4)
Issue: 4
Pages: 735-740
DOI
Related Report
Peer Reviewed
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