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Insufficiency of a novel anti-oncogene and mouse ovarian tumorigenesis

Research Project

Project/Area Number 16K15714
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

YAMADA Hidekazu  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (10254012)

Co-Investigator(Kenkyū-buntansha) 島 礼  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
伊藤 しげみ  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords卵巣がん / プロテインホスファターゼ / 婦人科腫瘍学
Outline of Final Research Achievements

In order to address the function of protein phosphatase 6 (PP6) loss on K-ras-initiated tumorigenesis in ovary. To do so, we developed tamoxifen-inducible K-rasG12D-expressing mice and double mutant (K-rasG12D-expressing and Ppp6c-deficient) mice in which K-rasG12D expression is driven by the cytokeratin 14 (K14) promoter. Using 8week old and 12 weeks old female mice, intrabursal injection of an adenovirus-Cre construct was conducted. Eight month after the induction, mice were dissected and ovary was examined. Both K-rasG12D-expressing mice and doubly-mutant mice showed no tumors in the ovary. The results showed that K-rasG12D expression using this system is not sufficient to develop ovarian tumors in mice.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-rasG12D-driven tumor promotion.2018

    • Author(s)
      Kurosawa K, Inoue Y, Kakugawa Y, Yamashita Y, Kanazawa K, Kishimoto K, Nomura M, Momoi Y, Sato I, Chiba N, Suzuki M, Ogoh H, Yamada H, Miura K, Watanabe T, Tanuma N, Tachi M, and Shima H
    • Journal Title

      Cancer Science

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Status of Uterine Leiomyosarcoma in the Tohoku Region: Results of the Tohoku Translational Center Development Network Survey2017

    • Author(s)
      Tokunaga H, Takahashi F, Yamamoto H, Honda T, Watanabe T, Shoji T, Sugiyama T, Yamada H, Tando T, Yoshinaga K, Kagabu S, Otsuki T, Kin S, Yokoyama Y, Wagatsuma S, Sato K, Sato H, Oishi T, Yoshida Y, Hayasaka T, Matsui T, Imai N, Nishigori H, Shimokawa H, Yaegashi N, Watanabe Y.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 22 Issue: 3 Pages: 541-547

    • DOI

      10.1007/s10147-017-1097-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of nedaplatin based concurrent chemoradiotherapy for uterine cervical cancer2016

    • Author(s)
      Kagabu M, Shoji T , Murakami K, Omi H, Honda T, Miura F, Yokoyama Y, Tokunaga H,Takano T, Ohta T , Shimizu D & Sato N, Soeda S , Watanabe T, Yamada H, Mizunuma H, Yaegashi N Nagase S,Tase T, Sugiyama T
    • Journal Title

      a Tohoku Gynecologic Cancer Unit Study. Int J Clin Oncol

      Volume: 21(4) Issue: 4 Pages: 735-740

    • DOI

      10.1007/s10147-016-0946-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 放射線治療後に局所に病巣が残存した子宮頸癌に対する子宮全摘は有効か?2016

    • Author(s)
      山田秀和、藤田信弘、大友圭子、田勢 亨
    • Organizer
      第39回日本産婦人科手術学会
    • Place of Presentation
      宮城県・仙台市
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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