Development of novel treatment and prevention for chronic eosinophilic rhinosinusitis using myeloid-derived suppressor cells.

• Project/Area Number: 16K15721
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Okayama University
• Principal Investigator: Okano Mitsuhiro 岡山大学, 医学部, 客員研究員 (60304359)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 好酸球性副鼻腔炎 / 骨髄由来免疫抑制細胞 / プロスタグランジンE2合成酵素 / 鼻茸 / PGE2 / PGE2合成酵素 / IL-10

Outline of Final Research Achievements

As compared with uncinate process mucosa, nasal polyp (NP) showed higher expression of myeloiod-derived suppressor cells (MDSC). In addition, NP from eosinophilic chronic rhinosinusitis (ECRS) showed higher expression of MDSC as compared with NP from non-ECRS. Moreover,lineage (-) HLA-DR (-) CD33 (+) MDSC showed higher expression of prostaglandin E2 synthetase-1 (PGES-1) mRNA as compared with lineage (-) cells as well as lingeage (-) HLA-DR (+) cells.
These results suggest that MDSC are involved in pathogenesis of ECRS via expression of PGES-1.

Research Products

• [Journal Article] Evaluation of a new and simple classification for endoscopic sinus surgery. (2017)
  • Author(s): Kanai K, Okano M, et al.
  • Journal Title: Allergy and Rhinology Volume: 8 Issue: 3 Pages: 118-125
  • DOI: 10.2500/ar.2017.8.0208
  • Open Access
• [Journal Article] The impact of chronic rhinosinusitis on long-term survival in lung transplantation recipients (2017)
  • Author(s): Kariya S, Okano M, Oto T, Higaki T, Haruna T, Noda Y, Nishizaki K.
  • Journal Title: Acta Oto-Laryngologica Volume: 137 Issue: 5 Pages: 529-533
  • DOI: 10.1080/00016489.2016.1247497
  • NAID: 120006463734
  • Peer Reviewed / Open Access
• [Journal Article] IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression (2017)
  • Author(s): Noyama Y, Okano M, et al.
  • Journal Title: Allergology International Volume: 66 Issue: 1 Pages: 42-51
  • DOI: 10.1016/j.alit.2016.04.017
  • NAID: 130005308495
  • ISSN: 1323-8930, 1440-1592
  • Open Access
• [Journal Article] Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts. (2016)
  • Author(s): Kanai K, Okano M, Fujiwara T, Kariya S, Haruna T, Omichi R, Makihara S, Hirata Y, Nishizaki K.
  • Journal Title: Allergology International Volume: 印刷中 Issue: 4 Pages: 414-419
  • DOI: 10.1016/j.alit.2016.03.003
  • NAID: 130005431326
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps (2016)
  • Author(s): Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
  • Journal Title: Allergology International Volume: 65 Issue: 1 Pages: 96-102
  • DOI: 10.1016/j.alit.2015.08.005
  • NAID: 130005290330
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] The role of prostaglandins in the pathophysiology of CRS and allergic rhinitis (2017)
  • Author(s): Mitsuhiro Okano
  • Organizer: International Society of Rhinology
  • Int'l Joint Research / Invited
• [Presentation] ブドウ球菌コンポーネントと上皮細胞の応答性 (2016)
  • Author(s): 岡野光博
  • Organizer: 日本鼻科学会
  • Place of Presentation: 宇都宮
  • Year and Date: 2016-10-13
  • Invited