| Project/Area Number |
16K15725
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福永 一朗 順天堂大学, 医学(系)研究科(研究院), 助教 (20746581)
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| Research Collaborator |
MINOWA Osamu
FUZIMOTO Ayumi
HATAKEYAMA Kaori
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 内耳 / ホーミング / 幹細胞 / 移植 / ケモカイン / 蝸牛 / 遺伝性難聴 / 内耳再生医療 / iPS細胞 / 幹細胞ホーミング / 難聴 |
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| Outline of Final Research Achievements |
Inner ear cell therapy for sensorineural hearing loss has been expected to be an effective therapy for hereditary deafness. We developed a strategy for inner ear cell therapy using bone marrow mesenchymal stem cells (MSC) and established the differentiation method for inner ear like cells from induced pluripotent stem (iPS) cell. For cell therapy targeting hereditary deafness, a more effective cell delivery system to induce the stem cells into cochlear tissue is required. Stem cell homing is one of the crucial mechanisms to be activated for efficient cell delivery to the cochlear tissue. In our study, MCP-1, SDF-1 and their receptors were found to be a key regulator for stem cell recruitment to the cochlear tissue. By activating stem cell homing, we developed a novel strategy to induce a number of stem cells into cochlear tissue.
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