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Application of biomaterials for regulation of osteoblast differentiation to craniosynostosis

Research Project

Project/Area Number 16K15746
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Plastic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISEKI Sachiko  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (80251544)

Co-Investigator(Kenkyū-buntansha) 由井 伸彦  東京医科歯科大学, 生体材料工学研究所, 教授 (70182665)
上田 晃一  大阪医科大学, 医学部, 教授 (90257858)
Co-Investigator(Renkei-kenkyūsha) Arun Kumar Rajendran  東京医科歯科大学, 大学院医歯学総合研究科, 大学院生
Research Collaborator Arisaka YOSHINORI  東京医科歯科大学, 生体材料工学研究所, 助教
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordscraniosynostosis / osteoblast / diffferentiation / polyrotaxane / ポリロタキサン / 頭蓋縫合早期癒合症 / 骨芽細胞分化 / 外科 / 生体分子 / 発生分化 / 歯学 / 再生医学
Outline of Final Research Achievements

Craniosynostosis involves the premature bony closure of the cranial sutures, which is due to early and rapid ossification. The current treatment modality is surgical separation of the fused bones to create the space. However, since the osteoblasts are in very active state, repeated closure occurs, which requires repeated surgeries.
Polyrotaxane (PRX), one of biomaterials can regulate differentiation of mesenchymal stem cells by changing the mobility of PRX surface. We have intended to utilize this property to regulate osteoblast differentiation to development the treatment minimizing repeated surgeries.
We found that different molecular mobility of PRX affects proliferation, mineralization, cytoskeleton organization and YAP localization of different type of osteoblasts. We could utilize the molecular mobility of PRX to regulate osteogenesis for avoiding repeated surgeries.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Injectable Shear-Thinning CaSO4/FGF-18-Incorporated Chitin-PLGA Hydrogel Enhances Bone Regeneration in Mice Cranial Bone Defect Model.2017

    • Author(s)
      Sivashanmugam A, Charoenlarp P, Deepthi S, Rajendran A, Nair SV, Iseki S, Jayakumar R.
    • Journal Title

      Injectable Shear-Thinning CaSO4/FGF-18-Incorporated Chitin-PLGA Hydrogel Enhances Bone Regeneration in Mice Cranial Bone Defect Model.

      Volume: 9 Issue: 49 Pages: 42639-42652

    • DOI

      10.1021/acsami.7b15845

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Role of Fibroblast Growth Factors in bone regeneration.2017

    • Author(s)
      Charoenlarp P., Arun Kumar R., Iseki S.
    • Journal Title

      Inflammation and Regeneration

      Volume: 37 Issue: 1 Pages: 10-10

    • DOI

      10.1186/s41232-017-0043-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Foxc2-expressing cells during mouse organogenesis.2017

    • Author(s)
      Amin M.B., Miura M. Uddin M.K., Islam M.J., Yoshida N., Iseki S., Kume T. Trainor P.A., Saitsu H. Kazushi Aoto.
    • Journal Title

      Congenital Anomalies

      Volume: 57 Issue: 1 Pages: 24-31

    • DOI

      10.1111/cga.12198

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intermediate phenotype between ADULT syndrome and EEC syndrome caused by R243Q mutation in TP63.2016

    • Author(s)
      Otsuki Y., Ueda K., Satoh C., Maekawa R., Yoshiura K., Iseki S.
    • Journal Title

      Plast Reconstr Surg Glob Open

      Volume: 4 Issue: 12 Pages: e1185-e1185

    • DOI

      10.1097/gox.0000000000001185

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Regulation of Osteogenic Differentiation by Utilizing Supramolecular Mobility of Polyrotaxanes for the Treatment of Craniosynostosis.2017

    • Author(s)
      Rajendran AK, Arisaka Y, Yui N, Iseki S.
    • Organizer
      第13回Craniosynostosis研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Application of biomaterials in osteogenesis2017

    • Author(s)
      Sachiko Iseki
    • Organizer
      The 6 Asian Biomaterials Congress along with APSAO 2017 meeting & 27th National Conference of SBAOI
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] RGD含有多孔性NanoClikハイブリッドゲルを利用した頭蓋冠骨修復2016

    • Author(s)
      Pornkawee Charoenlarpa, Rie Fujiharab, Yoshihiro Sasakib, Kazunari Akiyoshib, c, Sachiko Iseki
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都勧業会館「みやこめっせ」京都
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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