Research on pathophysiology of definitive tissue damage after inonizing irradiation and development of treatment

• Project/Area Number: 16K15752
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Jichi Medical University
• Principal Investigator: Yoshimura Kotaro 自治医科大学, 医学部, 教授 (60210762)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 放射線障害 / 創傷治癒 / 脂肪幹細胞

Outline of Final Research Achievements

Definitive radiation damage was assessed using mice model which underwent irradiation from 5Gy to 45Gy. It was revealed that radiation damage was highly dependent on total dose of radiation and fractioned protocol reduced the magnitude of tissue damage.