| Project/Area Number |
16K15753
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
須永 中 自治医科大学, 医学部, 助教 (00406117)
宇田 宏一 自治医科大学, 医学部, 准教授 (20337306)
吉村 浩太郎 自治医科大学, 医学部, 教授 (60210762)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 細胞系譜追跡 / Lineage tracing / 線維増殖性瘢痕 |
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| Outline of Final Research Achievements |
We established a transgenic mouse line in which we could trace the fate of hematpoietic stem cells with tdTomato and visualize collagen type 1-producing cells with EGFP. In hypertrophic scar model using the mice, all collagen type 1-producing cells derived from hematopoietic stem cells. Next, we tried profiling the cell in hypertrophic scars with flow cytometry, but failed due to lack of the transgenic mice. So, we re-established a transgenic mouse line to gain enough number of the mice.
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