The effects of nano-bubble water on wound healing

Research Project

Project/Area Number	16K15754
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Plastic surgery
Research Institution	Tokyo Medical University
Principal Investigator	Ida Yukiko 東京医科大学, 医学部, 講師 (00459504)
Co-Investigator(Kenkyū-buntansha)	柴田大東京医科大学, 医学部, 助教 (00421008) 松村一東京医科大学, 医学部, 主任教授 (80256263)
Research Collaborator	AOKI kohei
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	創傷治癒 / ナノバブル / 持続陰圧閉鎖療法 / 感染 / 洗浄
Outline of Final Research Achievements	We call water containing bubbles of nanometer size nano-bubble water(NBW). Our research is to investigate the effect of NBW on wound healing. When mixed with bacterial culture solution using oxygen in bubbles of NBW, growth of aerobic bacteria was promoted. That means NBW provided oxygen to bacteria. In animal experimentations, NBW provided oxygen to ischemic wound to promote the wound healing.
Academic Significance and Societal Importance of the Research Achievements	難治性創傷は生活習慣病の増加に伴い、その患者数は増加の一途をたどる疾患である。これに対する短期間で効果的な治療方法は、患者本人からだけではなく、社会全体からも求められている。酸素を含有させたナノバブル水は創傷治癒を促進する可能性を指摘することができ、今後の創傷治療における選択肢を広げることができたと考えられる。