| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
Damage associated molecular patters, DAMPs, are released from the damaged or stimulated cells and act on various types of cells through toll like receptors. These result the various cellular events including inflammasome activation. We investigated the molecular and cellular basis of DAMPs. We showed that DAMPs released from the cells by free molecular form, and/or enwrapped into the exosome. We identified that there are two types of DAMPs, naked, free molecule form and exosomal form.
In this project, we investigated the pathophysiological differences among two types of DAMPs, histones and HMGB1.We showed that HMGB1 was mainly present with the naked form. However in the case of histones, there are two types, naked and exosomal types. These may explain that exosomal histones are targeted to the remote organs resulting organs damages, including ARDS. However, naked HMGB1 may circulate and play roles for the development of systemic pathologic states including DIC.
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