| Project/Area Number |
16K15764
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
Ito Takashi 鹿児島大学, 医歯学総合研究科, 講師 (20381171)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 征郎 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
垣花 泰之 鹿児島大学, 医歯学域医学系, 教授 (20264426)
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| Research Collaborator |
HOSOKAWA Kazuya 藤森工業株式会社
NAGASATO Tomoka 藤森工業株式会社
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 抗凝固薬 / ヘパリン / ヘパリン起因性血小板減少症 / HIT / 血栓症 / ポイントオブケア / ヘパリン起因性血小板減少症（HIT） / 血栓 / 集中治療 |
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| Outline of Final Research Achievements |
Heparin is frequently used for preventing thrombosis. Heparin-induced thrombocytopenia (HIT), an adverse effect of heparin, is potentially lethal. So, an early diagnosis is needed to avoid iatrogenic worsening. In this study, we examined potential usefulness of total thrombus-formation analysis system (T-TAS) in HIT diagnosis. Platelet-rich thrombus formation in T-TAS is impaired when heparin is mixed with whole blood from healthy volunteers. However, platelet-rich thrombus formation in T-TAS is paradoxically augmented if heparin is mixed with whole blood from HIT patients. These findings indicate that T-TAS may be potentially useful in distinguishing patients with HIT from those without HIT. Further studies are needed to evaluate its clinical usefulness.
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