Sorting of secretory proteins trafficking and mini-modeling induction by osteocyte network
Project/Area Number |
16K15771
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
AMIZUKA Norio 北海道大学, 歯学研究院, 教授 (30242431)
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Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Tomoka 北海道大学, 大学院歯学研究院, 助教 (50739349)
TSUBOI Kanako 北海道大学病院, 医員 (50754610)
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Research Collaborator |
HONGO Hiromi
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 骨細胞 / 骨リモデリング / ミニモデリング / スクレロスチン / 骨細管 / リモデリング |
Outline of Final Research Achievements |
Osteocytic network shows geometrically-regular distribution of osteocytes and their cytoplasmic processes in association with bone maturation. Histological process of bone formation chronologically changed from mini-modeling in the early stage of the individual growth into bone remodeling in the adult stage. Osteocytic network did not show sclerostin in immature bone at the early stage of individual growth, while it abundantly synthesized sclerostin in mature bone at the later stage. Vitamin D analogue has been shown to induce mini-modeling even at the adult stage. In this study, it is likely that, when administered with vitamin D analogue, osteocytes appear to cease the sclerostin secretion, locally inducing mini-modeling-based bone formation.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] <b>Chronological immunolocalization of sclerostin and FGF23 in the mouse metaphyseal trabecular and cortical </b><b>bone </b>2017
Author(s)
Sakurai A., Hasegawa T., Kudo A., Shen Z., Nagai T., Abe M., Yoshida T., Hongo H., Yamamoto T., Yamamoto T., Oda K., Freitas de PHL., Li M., Sano H., Amizuka N.
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Journal Title
Biomedical Research
Volume: 38
Issue: 4
Pages: 257-267
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Biological application of focus ion beam-scanning electron microscopy (FIB-SEM) to the imaging of cartilaginous fibrils and osteoblastic cytoplasmic processes.2017
Author(s)
Hasegawa T., Endo T., Tsuchiya E., Kudo A., Zhao S., Moritani Y., Abe M.,Yamamoto T., Hongo H., Tsuboi K., Yoshida T., Nagai T., Khadiza N., Yokoyama A., Freitas de PHL., Li M., Amizuka N.
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Journal Title
J Oral Biosci.
Volume: 59
Issue: 1
Pages: 55-62
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] <b>Immunolocalization of osteocyte-derived molecules during bone fracture healing of mouse </b><b>ribs </b>2016
Author(s)
Liu Z., Yamamoto T., Hasegawa T., Hongo H., Tsuboi K., Tsuchiya E., Haraguchi M., Abe M., Freitas PHL., Kudo A., Oda K., Li M., Amizuka N.
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Journal Title
Biomedical Research
Volume: 37
Issue: 2
Pages: 141-151
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Frequency of teriparatide administration affects the histological pattern of bone formation in mice.2016
Author(s)
Yamamoto T., Hasegawa T., Sasaki M., Hongo H., Tsuboi K., Shimizu T., Ohta M., Haraguchi M., Takahata T., Oda K., Freitas PHL., Takakura A., Takao-Kawabata R., Isogai Y., Amizuka N.
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Journal Title
Journal of Endocrinology
Volume: 157巻7号
Pages: 2604-2620
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Histochemical examination of high-dose 1, 25(OH)2D3 effects on bone remodeling in young growing rats.2016
Author(s)
Sun J., Sun B., Wang W., Han X., Liu H., Du J., Feng W., Liu B., Amizuka N., Li M.
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Journal Title
The Journal of Molecular Histology
Volume: 47巻4号
Issue: 4
Pages: 389-399
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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