| Project/Area Number |
16K15771
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
AMIZUKA Norio 北海道大学, 歯学研究院, 教授 (30242431)
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| Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Tomoka 北海道大学, 大学院歯学研究院, 助教 (50739349)
TSUBOI Kanako 北海道大学病院, 医員 (50754610)
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| Research Collaborator |
HONGO Hiromi
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨細胞 / 骨リモデリング / ミニモデリング / スクレロスチン / 骨細管 / リモデリング |
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| Outline of Final Research Achievements |
Osteocytic network shows geometrically-regular distribution of osteocytes and their cytoplasmic processes in association with bone maturation. Histological process of bone formation chronologically changed from mini-modeling in the early stage of the individual growth into bone remodeling in the adult stage. Osteocytic network did not show sclerostin in immature bone at the early stage of individual growth, while it abundantly synthesized sclerostin in mature bone at the later stage. Vitamin D analogue has been shown to induce mini-modeling even at the adult stage. In this study, it is likely that, when administered with vitamin D analogue, osteocytes appear to cease the sclerostin secretion, locally inducing mini-modeling-based bone formation.
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