Basic research for development of effective inducing strategy of sublingual immune tolerance

Research Project

Project/Area Number	16K15772
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Morphological basic dentistry
Research Institution	Tohoku University
Principal Investigator	SUGAWARA Shunji 東北大学, 歯学研究科, 教授 (10241639)
Co-Investigator(Kenkyū-buntansha)	黒石智誠東北大学, 歯学研究科, 講師 (30400261)
Co-Investigator(Renkei-kenkyūsha)	TANAKA Yukinori JSPS, 特別研究員(PD) (60637958)
Research Collaborator	LU Lu SHISHIDO Kaori
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	免疫寛容 / 舌下免疫 / 舌下粘膜
Outline of Final Research Achievements	Sublingual immunotherapy (SLIT) is an allergen-specific treatment for allergy. SLIT increases allergen tolerance with safety and effective effect. However, the effect is not always strong enough, strategy to increase SLIT is anticipated. This study aimed at finding a substance that augment the effect of SLIT by using delayed-type hypersensitivity mouse mode. Among candidate substances that can induce regulatory T cells, we succeeded to find out one substance (referred to substance A). SLIT enhancing effect by substance A was long-lasting, but production fo retinoic acid by sublingual mucosal dendritic cells. We are still challenging to elucidate the underlying mechanism.