| Project/Area Number |
16K15776
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAYAMA Koji 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80150473)
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| Co-Investigator(Kenkyū-buntansha) |
門脇 知子 (筑波知子) 長崎大学, 医歯薬学総合研究科, 准教授 (70336080)
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| Co-Investigator(Renkei-kenkyūsha) |
YUKITAKE Hideharu 長崎大学, 医歯薬学総合研究科(歯学系), 技術職員 (30380984)
SHOJI Mikio 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (10336175)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病 / 細菌 / 分泌機構 / 発現調節 / 歯学 / 生体分子 |
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| Outline of Final Research Achievements |
We analyzed the regulatory mechanism of the PorXY two-component system that regulates the expression of component proteins constituting the type IX secretion system (T9SS) of the periodontal disease bacterium Porphyromonas gingivalis. It was found that the response regulator PorX interacts with the ECF sigma factor SigP, SigP regulates gene expression of T9SS component proteins, and Art, which is one of the T9SS cargo proteins, dominates the sensor histidine kinase PorY.
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