Effects of inflammatory mediators produced by oral bacteria on blood-brain barrier and neurological diseases
| Project/Area Number |
16K15777
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉川 圭介 埼玉医科大学, 医学部, 講師 (10435860)
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| Research Collaborator |
NOMURA ryota
YAMAMOTO shinji
IWASA kensuke
HARUTA asuka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔内細菌 / 神経疾患 / 多発性硬化症 / 口腔細菌 / 歯周病 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the influence of Streptococcus mutans, a causative agent of dental caries, and Porphyromonas gingivalis, a causative agent of periodontitis, on neuronal disease. The cells of S. mutans and P. gingivalis were administered to cuprizone-induced demyelination model mice, which are experimental animal models of multiple sclerosis, and the myelin contents after 5 weeks were evaluated. Administration of S. mutans did not affect demyelination levels, but P. gingivalis suppressed demyelination.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔内の二大感染症がう蝕と歯周病であり、それぞれの主な原因菌としてStreptococcus mutans（S. mutans）とPorphyromonas gingivalis（P. gingivalis）が有名である。S. mutansは歯科治療中の出血により、P. gingivalisは慢性的な歯周炎により血液中に侵入すると考えられている。本研究により、P. gingivalisの血中内投与が神経疾患である多発性硬化症の病態を軽くする実験結果が得られた。P. gingivalis菌体外に多発性硬化症の治療候補成分が含まれている可能性がある。
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Report
(4 results)
Research Products
(13 results)
