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Identification of the target genes of glucocorticoid receptor in the pathogenesis of steroid-induced osteoporosis

Research Project

Project/Area Number 16K15781
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionNagasaki University

Principal Investigator

KOMORI Toshihisa  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (00252677)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsグルココルチコイド / ステロイド性骨粗鬆症 / Fkbp5 / 骨形成 / 骨吸収 / 骨芽細胞 / 骨細胞
Outline of Final Research Achievements

Steroids are effective drugs for inflammatory diseases and autoimmune diseases. However, steroids most frequently induce secondary osteoporosis. The risk of bone fracture in the patients with steroid treatment is about 30-50%. Trabecular bone is reduced and the fractures of vertebral body and femoral neck occur in the patients with steroid treatment. Fkbp5 is a shaperon molecule of glucocorticoid receptor, and Fkbp5 knockout mice showed severely reduced bone formation by glucocorticoid treatment. We tried to identify the target genes of glucocorticoid receptor, which are responsible for steroid-induced osteoporosis, using Fkbp5 knockout mice.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (21 results)

All 2018 2017 2016

All Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Runx2, an inducer of osteoblast and chondrocyte differentiation2018

    • Author(s)
      Komori T
    • Journal Title

      Histochem Cell Biol

      Volume: 印刷中 Issue: 4 Pages: 313-323

    • DOI

      10.1007/s00418-018-1640-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨・運動器領域の基礎研究の国内外の動向2018

    • Author(s)
      小守壽文,宿南知佐,小林泰浩,池川志郎
    • Journal Title

      THE BONE

      Volume: 31 Pages: 91-98

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy2017

    • Author(s)
      Yang Mengyu、Arai Atsushi、Udagawa Nobuyuki、Hiraga Toru、Lijuan Zhao、Ito Susumu、Komori Toshihisa、Moriishi Takeshi、Matsuo Koichi、Shimoda Kouji、Zahalka Ali H.、Kobayashi Yasuhiro、Takahashi Naoyuki、Mizoguchi Toshihide
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 4928-4928

    • DOI

      10.1038/s41598-017-05401-1

    • NAID

      120006576162

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation2017

    • Author(s)
      Miyazaki Toshihiro、Inoue Maaya、Baba Tomomi T.、Komori Toshihisa
    • Journal Title

      Journal of Oral Biosciences

      Volume: 59 Issue: 2 Pages: 113-120

    • DOI

      10.1016/j.job.2017.03.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨形成を制御する転写因子Runx2とOsterix2017

    • Author(s)
      川根徹也,小守壽文
    • Journal Title

      分子リウマチ治療

      Volume: 10 Pages: 28-32

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Overexpression of Sp7 in odontoblasts results in dentinogenesis imperfecta due to the inhibition of odontoblast maturation2017

    • Author(s)
      Miyazaki T, Inoue M, Baba T, Komori T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of Runx2 in skeletal development2017

    • Author(s)
      Komori T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 962 Pages: 83-93

    • Related Report
      2016 Research-status Report
  • [Journal Article] Immunohistochemical analysis of dentin matrix protein 1 (Dmp1) phosphorylation by Fam20C in bone: implications for the induction of biomineralization2017

    • Author(s)
      Oya K, Ishida K, Nishida T, Sato S, Kishino M, Hirose K, Ogawa Y, Ikebe K, Takeshige F, Yasuda H, Komori T, Toyosawa S
    • Journal Title

      Histochemistry and Cell Biology

      Volume: 147 Issue: 3 Pages: 345-351

    • DOI

      10.1007/s00418-016-1490-z

    • Related Report
      2016 Research-status Report
  • [Journal Article] Glucocorticoid signaling and bone biology2016

    • Author(s)
      Komori T
    • Journal Title

      Hormone and Metabolic Research

      Volume: 48 Issue: 11 Pages: 755-763

    • DOI

      10.1055/s-0042-110571

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development.2016

    • Author(s)
      Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 1391-1404

    • DOI

      10.1002/jbmr.2814

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Overexpression of BCLXL in Osteoblasts Inhibits Osteoblast Apoptosis and Increases Bone Volume and Strength2016

    • Author(s)
      Moriishi T, Fukuyama R, Miyazaki T, Furuichi T, Ito M, Komori T.
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 1366-1380

    • DOI

      10.1002/jbmr.2808

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cell Death in Chondrocytes, Osteoblasts, and Osteocytes2016

    • Author(s)
      Komori T
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 17 Issue: 12 Pages: 2045-2045

    • DOI

      10.3390/ijms17122045

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A role of Runx2 in the proliferation of osteoblast precursors2017

    • Author(s)
      Komori T
    • Organizer
      RUNX PHILADELPHIA 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the functions of Runx2 in differentiated osteoblasts2017

    • Author(s)
      Qin X, Komori T
    • Organizer
      RUNX PHILADELPHIA 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レドロン酸投与が骨細胞マーカー Dmp1 に及ぼす影響について2017

    • Author(s)
      社領美紀,佐藤淳,宇佐美悠,廣瀬勝俊,大家香織,小守壽文,豊澤 悟
    • Organizer
      第59回歯科基礎医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Fam20C 過剰発現マウスにおける骨組織の変化について2017

    • Author(s)
      廣瀬勝俊,宇佐美悠,佐藤淳,大家香織,小守壽文,豊澤悟
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ステロイドシグナルとbone biology2017

    • Author(s)
      小守 壽文
    • Organizer
      第35回日本骨代謝学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cbfb1とCbfb2 アイソフォームは骨格形成過程において重要な役割を果たす2016

    • Author(s)
      姜晴,秦昕,小守寿人,松尾友紀,宮崎敏博,森石武史,小守壽文
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Fam20C過剰マウスの作成とその解析について2016

    • Author(s)
      廣瀬勝俊,佐藤淳,社領美紀,野田百合,小守壽文,豊澤悟
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] PTH アナボリック作用に対する骨髄間葉系幹細胞の寄与2016

    • Author(s)
      楊孟雨,溝口利英,宇田川信之,松尾光一,小守壽文,森石武史,小林泰浩,高橋直之
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] アポトーシス抑制遺伝子BCLXLを骨芽細胞に過剰発現させると骨量が増加し生涯を通して骨量が維持される2016

    • Author(s)
      森石武史,福山亮,古市達哉,伊東昌子,小守壽文
    • Organizer
      第34回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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