Control of pulpal inflammation and hard tissue regeneration by miR-21, a modulator of cross-talk between inflammation and tissue regeneration
| Project/Area Number |
16K15795
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
KAWASHIMA Nobuyuki 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60272605)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | dental pulp cell / micro RNA / miR-21 / NFkB signaling / inflammation / LPS / signaling cascade / differentiation / マイクロRNA / miR21 / 歯髄炎 / 炎症性サイトカイン / 炎症制御 / 分化誘導 / NFkBシグナル / ERKシグナル / 歯髄幹細胞 / 炎症性メディエーター / マクロファージ / NFkB / 炎症 / 組織再生 |
|---|
| Outline of Final Research Achievements |
miR-21 was up-regulated in the inflamed rat dental pulp tissue, and lipopolysaccharides induced expression of miR-21 in the human dental pulp cells. miR-21 down-regulated NFkB signaling via degradation of TNF receptor-associated factor (TRAF) 6 and programmed cell death (PDCD) 4. miR-21 also promoted osteopontin expression. miR-21 may control the progress of pulpal inflammation and modulate the hard tissue formation in the dental pulp tissue.
|
Report
(3 results)
Research Products
(12 results)
