| Project/Area Number |
16K15805
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古谷野 潔 九州大学, 歯学研究院, 教授 (50195872)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 間葉系幹細胞 / 歯科補綴学 / メカノバイオロジー |
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| Outline of Final Research Achievements |
Overload is one of the most important factors leading to deterioration of periodontal and peri-implant tissue and control of load is a crucial factor for long-time good prognosis. In the present study, we pursued the possibility of systemically-administered mesenchymal stem cells (MSC), which has a characteristic of inflammation-homing, as a sensor for overload. MSC was obtained from MSC gene-transfected rat and systemically administered. In parallel, implants were placed into rat bone and pathological overload was provided to implants. As a result, MSC accumulated to bone around overloaded implant. This may imply the capability of MSC as a mechanosensor to visualize the overload.
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