Development of new tooth adhesives with a sensing capability of debonding and release functions of antibacterial and regenerative agents

• Project/Area Number: 16K15809
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Yoshida Yasuhiro 北海道大学, 歯学研究院, 教授 (90281162)
• Co-Investigator(Kenkyū-buntansha): 槇田 洋二 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 (80357988)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯質接着 / デボンディング / 薬剤除法 / 2次う蝕 / 抗菌 / 層状化合物 / フッ化セチルピリジニウム / 生体材料 / 再生 / DDS / 殺菌

Outline of Final Research Achievements

To prevent secondary caries through debonding of adhesives from the restored tooth surfaces, we have tried to develop new functional materials which have like a sensing capability of debonding. As new functions, adhesive materials release drugs, such as antibacterial and regenerative agents between materials and tooth surface after debonding of tooth restorations. These agents are ideally not released during the interface between adhesive material and tooth surface keeps its integrity and are released immediately after debonding. We successfully developed high functional materials and are planning to apply patents. The data should be opened to the public after its patent publication.

Academic Significance and Societal Importance of the Research Achievements

歯質との接着界面は永久に完全な状態を保てるわけではない。歯質接着界面の劣化に伴い発生する2次う蝕を抑制するには，歯質接着面の剥離を検知して剥離時に剥離部位にのみ薬剤を放出する新しい歯質接着材を開発する必要がある。本研究では，剥離に伴う変形で薬剤を徐放することで劣化センサー機能付インテリジェントマテリアルの実現を目指し，新しいDDS型フィラーの開発に取り組んだ結果，特許出願につながる成果を得た。

Research Products

• [Int'l Joint Research] KU Leuven (University of Leuven)(ベルギー)
• [Journal Article] Bacterial adhesion not inhibited by ion-releasing bioactive glass filler. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Maruo Y, Sano H, Yoshida Y, Van Meerbeek B.
  • Journal Title: Dent Mater Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical interaction mechanism of 10-MDP with zirconia (2017)
  • Author(s): Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa, Yoshiyuki Tamada, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek, Satoshi Hayakawa
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45563-45563
  • DOI: 10.1038/srep45563
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model. (2017)
  • Author(s): Cardoso MV, Chaudhari A, Yoshihara K, Mesquita MF, Yoshida Y, Van Meerbeek B, Vandamme K, Duyck J.
  • Journal Title: Int J Oral Maxillofac Implants. Volume: 32 Issue: 2 Pages: 282-290
  • DOI: 10.11607/jomi.5074
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sandblasting may damage the surface composite CAD-CAM blocks. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Maruo Y, Nishigawa G, Irie M, Yoshida Y, Ban Meerbeek B.
  • Journal Title: Dental Materials Volume: 33 Issue: 3 Pages: 124-135
  • DOI: 10.1016/j.dental.2016.12.003
  • NAID: 120006401576
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effectiveness and stability of silane coupling agent incorporated in ‘universal’ adhesives (2016)
  • Author(s): Kumiko Yoshihara, Noriyuki Nagaoka, Akinari Sonoda, Yukinori Maruo, Yoji Makita, Takumi Okihara, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek
  • Journal Title: Dental Materials Volume: 32 Issue: 10 Pages: 1218-1225
  • DOI: 10.1016/j.dental.2016.07.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interference of functional monomers with polymerization efficiency of adhesives (2016)
  • Author(s): Hanabusa M, Yoshihara K, Yoshida Y, Okihara T, Yamamoto T, Momoi Y, Van Meerbeek B
  • Journal Title: European Journal of Oral Sciences Volume: 124 Issue: 2 Pages: 204-209
  • DOI: 10.1111/eos.12245
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant