| Project/Area Number |
16K15813
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西谷 直之 岩手医科大学, 薬学部, 教授 (10286867)
藤原 尚樹 岩手医科大学, 歯学部, 准教授 (20190100)
大津 圭史 岩手医科大学, 歯学部, 准教授 (60509066)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ヘルトビッヒ上皮鞘 / 上皮間葉転換 / 歯の再生 / 間葉上皮転換 / セマフォリン / マラッセ上皮遺残 / 歯根膜 / エナメル上皮幹細胞 / エナメル上皮細胞 / マラッセ残存上皮 |
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| Outline of Final Research Achievements |
The aim of this project is to produce dental epithelial stem cells from mesenchymal cells in periodontal ligament by mesenchymal-epithelial transition (MET) and to utilize the epithelial cells for tooth regeneration. In order to obtain their cells, we tried to inhibit the epithelial-mesenchymal transition (EMT) and induce epithelial cells from EMT cells. As a result, Rho activator, Semaphorin4A and 4D, LPA (lysophospholipid) activate Rho signal and inhibited the EMT, and further induced MET and hyper-epithelium. But, it was difficult to obtain enough cell number of dental epithelial cells, it remains as further problem.
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