Effect of dental pulp stem cell on peripheral nerve regeneration: An experimental study in the nude rat model.

• Project/Area Number: 16K15817
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: University of Tsukuba
• Principal Investigator: Bukawa Hiroki 筑波大学, 医学医療系, 教授 (80173558)
• Co-Investigator(Kenkyū-buntansha): 石川 博 日本歯科大学, 生命歯学部, 客員教授 (30089784)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯髄幹細胞 / 神経再生 / 再生医療

Outline of Final Research Achievements

In this study, we aimed to examine the mechanism and regenerative potential of dental pulp stem cells for peripheral nerve regeneration compared with control conduits without dental pulp stem cells and autografts in a system of nude rat sciatic nerve defect. A 10 mm gap in sciatic nerve regenerate 2 weeks after injury in control conduits without dental pulp stem cells. It need more investigation of method for culturing dental pulp stem cells in collagen tube as scaffold.