Development of the immunotherapy targeting the cancer antigen CDCA5
| Project/Area Number |
16K15829
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University (2017)
Kitasato University (2016) |
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Principal Investigator |
OKAMOTO MASATO 大阪大学, 薬学研究科, 寄附講座教授 (10243718)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌免疫療法 / 口腔癌 / CDCA5 / 癌ワクチン / 癌抗原 |
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| Outline of Final Research Achievements |
The prognosis of the patients with advanced oral cancer is very poor. Although immunotherapy of cancer is expected in recent years, its effect is still limited. We have found CDCA5 antigen which express specifically in oral cancer cells. We have clarified that the HLA class I-restricted, and HLA class II-restricted epitopes included in CDCA5 protein strongly induced CDCA5-specific cytotoxic T lymphocytes (CTLs) and type I helper T cells (Th1), respectively, and that these cells elicited anti-tumor effect in the xenograft mouse model bearing the oral squamous cell carcinoma cell lines. Based on these results, we made the CDCA5 peptide in GMP grade, and are going to start the phase I clinical study to evaluate the safety and anti-cancer effects of these CDCA5 peptides. At the same time, we also succeeded in a cloning of a T-cell receptor (TCR) genes from the above CTL and Th1 cells, and made CDCA5 specific TCR-engineered T lymphocytes.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Feasibility and Immune Response of WT1 Peptide Vaccination in Combination with OK-432 for Paediatric Solid Tumors.2018
Author(s)
Hirabayashi K, Yanagisawa R, Saito S, Higuchi Y, Koya T, Sano K, Koido S, Okamoto M, Sugiyama H, Nakazawa Y, Shimodaira S.
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Journal Title
Anticancer Res.
Volume: 38
Issue: 4
Pages: 2227-2234
DOI
Related Report
Peer Reviewed
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[Journal Article] Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer2018
Author(s)
Matsuda T, Takeuchi H, Sakurai T, Mayanagi S, Booka E, Fujita T, Higuchi H, Taguchi J, Hamamoto Y, Takaishi H, Kawakubo H, Okamoto M, Sunamura M, Kawakami Y, Kitagawa Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance of Wilms’ tumor 1 expression in patients with pancreatic ductal adenocarcinoma2018
Author(s)
Kanai T, Ito Z, Oji Y, Suka M, Nishida S, Takakura K, Kajihara M, Fujioka S, Misawa T, Akiba T, Yanagisawa H, Saruta M, Okamoto M, Sugiyama H, Koido
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma.2017
Author(s)
Fukuda K, Funakoshi T, Sakurai T, Nakamura Y, Mori M, Tanese K, Tanikawa A, Taguchi J, Fujita T, Okamoto M, Amagai M, Kawakami Y.
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Journal Title
Melanoma Research.
Volume: in press
Issue: 4
Pages: 326-334
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis.2016
Author(s)
Takahashi H, Shimodaira S, Ogasawara M, Ota S, Kobayashi M, Abe H, Morita Y, Nagai K, Tsujitani S, Okamoto M, Suzuki Y, Nakanishi Y, Yonemitsu Y
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Journal Title
Cancer Immunol Immunother
Volume: 65
Issue: 9
Pages: 1099-111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comprehensive assessment of the prognosis of pancreatic cancer: peripheral blood neutrophil-lymphocyte ratio and immunohistochemical analyses of the tumour site.2016
Author(s)
Takakura K, Ito Z, Suka M, Kanai T, Matsumoto Y, Odahara S, Matsudaira H, Haruki K, Fujiwara Y, Saito R, Gocho T, Nakashiro K, Hamakawa H, Okamoto M, Kajihara M, Misawa T, Ohkusa T, Koido S
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Journal Title
Scand J Gastroenterol
Volume: 51
Issue: 5
Pages: 610-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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