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Identification of novel oral squamous cell carcinoma-related genes for oder-made treatment.

Research Project

Project/Area Number 16K15831
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

Shumozato Kazuo  愛知学院大学, 歯学部, 非常勤講師 (00158966)

Co-Investigator(Kenkyū-buntansha) 野本 周嗣  愛知学院大学, 歯学部, 教授 (40300967)
宮部 悟  愛知学院大学, 歯学部, 講師 (40534582)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords口腔扁平上皮癌 / 口腔白板症 / 口腔細菌叢 / 唾液検体 / 次世代シークエンサ / 口腔扁平上皮癌バイオマーカ / 口腔扁平上皮癌遺伝子変異 / 口腔扁平上皮癌細菌叢 / マイクロアレイ / 次世代シークエンサー / OSCC遺伝子変異 / OSCC口腔細菌叢 / 遺伝子変異 / 口腔内細菌叢 / 口腔癌 / 発現アレイ / メチル化アレイ / がん関連遺伝子 / 扁平上皮癌
Outline of Final Research Achievements

Recently, the possibility that oral microbiomes are associated with oral squamous cell carcinoma (OSCC) initiation and progression has attracted attention; however, this association is still unclear. Here, we comprehensively analyze the microbiome profiles of saliva and tissue samples using next-generation sequencing followed by determining the association between oral microbiome profiles and OSCC to detect a novel OSCC biomarker for diagnosis, prognosis and sensitivity of treatment.The results suggesting a strong association of these bacteria with OSCC. Especially, phylum Fusobacterium was significantly associated with early recurrence of OSCC. Thus, oral microbiome analysis may have a potential of novel OSCC detection and prognostic tool.

Academic Significance and Societal Importance of the Research Achievements

口腔扁平上皮癌(OSCC)の大部分は肉眼的に発見可能であるが進行癌として診断されることも少なくない。そのことが予後不良の一因となっており、早期発見のための信頼性の高い簡便な診断マーカの開発が課題である。本研究では、採取が簡便で臨床応用しやすい唾液検体の細菌叢解析を行い、口腔細菌の臨床的な意義を検討した。結果、OSCCでのFusobacteria門、Fusobacterium属の増加やFirmicutes門、Streptococcus属の減少がOSCC診断に応用できる可能性が示され、Fusobacteria門やFusobacterium属の割合増加が予後増悪因子となる可能性が示唆された。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Changes in Oral Microbial Profiles Associated With Oral Squamous Cell Carcinoma vs Leukoplakia2019

    • Author(s)
      Hashimoto, Dai Shimizu, Sho Hirabayashi, Sei Ueda, Satoru Miyabe, Ichiro Oh-Iwa, Toru Nagao, Kazuo Shimozato, Shuji Nomoto
    • Journal Title

      J Investig Clin Dent . 1-7

      Volume: 10 Issue: 4 Pages: 1-7

    • DOI

      10.1111/jicd.12445

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌に関連した口腔細菌叢の新規臨床的バイオマーカとしての有用性2019

    • Author(s)
      橋本健吾、野本周嗣、上田 整、宮部 悟、大岩伊知郎、長尾 徹、下郷和雄
    • Organizer
      第64回 日本口腔外科学会総会・学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Changes of Oral Microbiome Profiles Associated With Oral Squamous Cell Carcinoma.2018

    • Author(s)
      Kengo Hashimoto, Shuji Nomoto, Sho Hirabayashi, Sei Ueda, Oh-iwa Ichiro, Toru Nagao, Kazuo Shimozato
    • Organizer
      American association of cancer research annual meeting 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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