• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Omic analysis from single cell circulating tumor cells of oral cancer

Research Project

Project/Area Number 16K15833
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Surgical dentistry
Research InstitutionNational Cancer Center Japan

Principal Investigator

Kazufumi Honda  国立研究開発法人国立がん研究センター, 研究所, ユニット長 (10260936)

Co-Investigator(Kenkyū-buntansha) 森 泰昌  国立研究開発法人国立がん研究センター, 中央病院, 医員 (00296708)
吉本 世一  国立研究開発法人国立がん研究センター, 中央病院, 科長 (00462242)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords末梢循環腫瘍細胞 / 1細胞解析 / オミクス解析 / 末梢腫瘍循環細胞 / ゲノム解析 / 癌 / 外科 / 歯学
Outline of Final Research Achievements

Liquid biopsy has recently gained attention as a real-time monitoring method for patients with cancer. Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) released into the bloodstream from both the primary tumor and metastases may reflect current tumor status. Although it is considering that CTCs are consisting the heterogeneous of population, the biological behavior of single cell CTC has not identified yet. To identify behavior of single cell CTC, we developed the omics analysis of single cell CTC.

Report

(2 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (11 results)

All 2018 2017 2016

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Serum apolipoprotein A2 isoforms in autoimmune pancreatitis2018

    • Author(s)
      Kobayashi Takashi、Sato Yu、Nishiumi Shin、Yagi Yosuke、Sakai Arata、Shiomi Hideyuki、Masuda Atsuhiro、Okaya Shinobu、Kutsumi Hiromu、Yoshida Masaru、Honda Kazufumi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 497 Issue: 3 Pages: 903-907

    • DOI

      10.1016/j.bbrc.2018.02.170

    • NAID

      120006604668

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy2017

    • Author(s)
      Shoji Hirokazu、Tada Kohei、Kitano Shigehisa、Nishimura Takashi、Shimada Yasuhiro、Nagashima Kengo、Aoki Kazunori、Hiraoka Nobuyoshi、Honma Yoshitaka、Iwasa Satoru、Takashima Atsuo、Kato Ken、Boku Narikazu、Honda Kazufumi、Yamada Tesshi、Heike Yuji、Hamaguchi Tetsuya
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 56 Pages: 95083-95094

    • DOI

      10.18632/oncotarget.18297

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Actinin-1 and actinin-4 play essential but distinct roles in invadopodia formation by carcinoma cells2017

    • Author(s)
      Yamaguchi Hideki、Ito Yuumi、Miura Nami、Nagamura Yuko、Nakabo Ayaka、Fukami Kiyoko、Honda Kazufumi、Sakai Ryuichi
    • Journal Title

      European Journal of Cell Biology

      Volume: 96 Issue: 7 Pages: 685-694

    • DOI

      10.1016/j.ejcb.2017.07.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma.2017

    • Author(s)
      Shiraishi H, Fujiwara Y, Kakuya T, Tsuta K, Motoi N, Miura N, Watabe Y, Watanabe SI, Noro R, Nagashima K, Huang W, Yamada T, Asamura H, Ohe Y, Honda K.
    • Journal Title

      Biomark Med.

      Volume: 11 Issue: 9 Pages: 721-731

    • DOI

      10.2217/bmm-2017-0150

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer.2017

    • Author(s)
      Kakuya T, Mori T, Yoshimoto S, Watabe Y, Miura N, Shoji H, Onidani K, Shibahara T, Honda K.
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: 46(8) Issue: 8 Pages: 968-976

    • DOI

      10.1016/j.ijom.2017.03.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of highly sensitive biomarkers that can aid the early detection of pancreatic cancer using GC/MS/MS-based targeted metabolomics.2016

    • Author(s)
      Hirata Y., Ioka T., et al.
    • Journal Title

      Clin. Chim. Acta.

      Volume: Feb. 16 Pages: 98-104

    • DOI

      10.1016/j.cca.2017.02.011

    • NAID

      120006375910

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Next-generation sequencing of circulating tumor cells isolated from peripheral blood of patients with head and neck or gastrointestinal cancer,2017

    • Author(s)
      Kaoru Onidani, Seiichi Yoshimoto, Nami Miura, Hirokazu Shoji, Ken Kato, Takahiko Shibahara, Kazufumi Honda
    • Organizer
      ESMO Asia2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次世代シーケンサーによる血中循環腫瘍細胞(CTCs)の遺伝子変異プロファイリング2017

    • Author(s)
      鬼谷 薫、吉本世一、三浦奈美、庄司広和、加藤 健、柴原孝彦、本田一文
    • Organizer
      第37回日本分子腫瘍マーカー研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Next-generation sequencing of circulating tumor cells isolated from peripheral blood of patients with head and neck or gastrointestinal cancer2017

    • Author(s)
      Kaoru Onidani, Seiichi Yoshimoto, Nami Miura, Hirokazu Shoji, Ken Kato, Takahiko Shibahara, Kazufumi Honda
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 次世代シーケンサーによる血中循環腫瘍細胞(CTCs)の遺伝子プロファイリング2017

    • Author(s)
      鬼谷 薫、柴原孝彦、本田一文
    • Organizer
      第62回日本口腔外科学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer2017

    • Author(s)
      Kaoru Onidani, Takanori Kakuya, Nami Miura, Hirokazu Shoji, Takahiko Shibahara, Kazufumi Honda
    • Organizer
      第76回日本癌学会
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-03-11  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi