| Project/Area Number |
16K15839
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 浩 九州大学, 歯学研究院, 助教 (00421313)
加藤 大樹 九州大学, 医学(系)研究科(研究院), 研究員 (30452709)
廣藤 雄太 (広藤 雄太) 九州大学, 歯学研究院, 助教 (80759746)
山座 治義 九州大学, 歯学研究院, 准教授 (30336151)
増田 啓次 九州大学, 大学病院, 講師 (60392122)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ダウン症 / ゲノム編集 / 乳歯由来幹細胞 / ヒト脱落乳歯由来幹細胞 / ダウン症候群 / 歯髄幹細胞 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
We examined the pathology of down syndrome using stem cells from human exfoliated deciduous teeth (SHED) derived from a patient with down syndrome. Furthermore, we attempted to develop a system to eliminate excess chromosome 21 by genome editing. We revealed that neurodevelopment ability of SHED derived from a patient was lower than SHED derived from a typically developing child. In addition, we established a system to eliminate a targeted chromosome.
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