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A novel approach to an investigation into the control mechanism of mastication and swallowing by measuring jaw movements with six degrees of freedom and bio-information

Research Project

Project/Area Number 16K15840
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIDA Noriaki  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40230750)

Co-Investigator(Kenkyū-buntansha) 古賀 義之  長崎大学, 病院(歯学系), 講師 (50175329)
森田 幸子  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (00631574)
中村 文  長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (50711959)
藤下 あゆみ  長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30755723)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords咀嚼 / 嚥下 / 顎運動 / 筋電図 / モーションキャプチャー / 筋活動 / モーションキャチャー / 6自由度 / 神経伝達物質 / 神経伝達物物質 / 顎口腔機能解析 / 6自由度顎運動
Outline of Final Research Achievements

We developed a novel device that can measure jaw movements with six degrees of freedom and record activities of masticatory muscles in mice. The 3D movements at any points on the mandible, for instance, points of the condyle, molar and incisor could be calculated through integration and registration of the kinematic data of the jaw movements and the geometric data of the mandible on four markers. This study suggests that neurotransmitters have an important role in controlling the mechanism of stomatognathic fuctions such as mastication and swallowing.

Academic Significance and Societal Importance of the Research Achievements

本研究では、高速度カメラとモーションキャプチャーシステムを組み合わせることで、光学式6自由度顎運動計測システムを開発し、下顎頭の滑走運動や臼歯部における食物の粉砕臼磨運動など、高精度多点同時計測が可能となった。これまでに、ニューロトランスミッターを脳室内に投与し、咀嚼・嚥下運動を制御するニューロンの神経活動変化を記録した研究は数多くあるものの、最終的な運動出力である顎運動、舌運動、筋活動を計測した研究は行われていない。咀嚼・嚥下運動の末梢性制御機構は、少しづつ明らかにされている中で、今回先進的な実験系を確立し、新たに中枢性制御機構を運動出力を含めて解明する準備が整った。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Development and evaluation of a jaw-tracking system for mice: reconstruction of three-dimensional movement trajectories on an arbitrary point on the mandible2019

    • Author(s)
      Moriuchi E, Hamanaka R, Koga Y, Fujishita A, Yoshimi T, Yasuda G, Kohara H, Yoshida N
    • Journal Title

      Biomedical Engineering Online

      Volume: 18 Issue: 1 Pages: 59-59

    • DOI

      10.1186/s12938-019-0672-z

    • NAID

      120006987707

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term skeletal stability in the treatment of mandibular prognathism with a physiological positioning strategy.2019

    • Author(s)
      Miura K, Yamaoka S, Arizono K, Ohba S, Koga T, Kawasaki T, Yoshida N, Asahina I
    • Journal Title

      Br J Oral Maxillofac Surg

      Volume: 57(6) Pages: 529-535

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion2018

    • Author(s)
      Narahara H, Sakai E, Yamaguchi Y, Narahara S, Iwatake M, Okamoto K, Yoshida N, Tsukuba T
    • Journal Title

      J Cell Physiol

      Volume: 234 Issue: 1 Pages: 486-499

    • DOI

      10.1002/jcp.26605

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats2018

    • Author(s)
      Ino-Kondo Airi、Hotokezaka Hitoshi、Kondo Takanobu、Arizono Keira、Hashimoto Megumi、Hotokezaka Yuka、Kurohama Takeshi、Morita Yukiko、Yoshida Noriaki
    • Journal Title

      The Angle Orthodontist

      Volume: - Issue: 4 Pages: 474-482

    • DOI

      10.2319/112017-801.1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological positioning strategy alters condylar position after mandibular ramus sagittal split osteotomies for mandibular prognathism2018

    • Author(s)
      Ohba S, Ozaki H, Miura KI, Koga T, Kawasaki T, Yoshida N, Asahina I
    • Journal Title

      Cranio

      Volume: 36 Issue: 3 Pages: 181-188

    • DOI

      10.1080/08869634.2017.1314432

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of osseous healing after sagittal split ramus osteotomy and intraoral vertical ramus osteotomy2018

    • Author(s)
      Rokutanda S, Yamada S, Yanamoto S, Omori K, Fujimura Y, Morita Y, Rokutanda H, Kohara H, Fujishita A, Nakamura T, Yoshimi T, Yoshida N, Umeda M
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 47 Issue: 10 Pages: 1316-1321

    • DOI

      10.1016/j.ijom.2018.05.013

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of motor coordination of masseter and temporalis muscles for increased masticatory efficiency in mice2017

    • Author(s)
      Yoshimi T.、Koga Y.、Nakamura A.、Fujishita A.、Kohara H.、Moriuchi E.、Yoshimi K.、Tsai C.Y.、Yoshida N.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 44 Issue: 5 Pages: 363-374

    • DOI

      10.1111/joor.12491

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Numeric simulation model for long-term orthodontic tooth movement with contact boundary conditions using the finite element method2017

    • Author(s)
      Hamanaka Ryo、Yamaoka Satoshi、Anh Tuan Nguyen、Tominaga Jun-ya、Koga Yoshiyuki、Yoshida Noriaki
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 152 Issue: 5 Pages: 601-612

    • DOI

      10.1016/j.ajodo.2017.03.021

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2016

    • Author(s)
      Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
    • Journal Title

      Eur J Orthod

      Volume: 38 Issue: 4 Pages: 563-569

    • DOI

      10.2319/110416-794.1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of diabetes on tooth movement and root resorption after orthodontic force application in rats.2016

    • Author(s)
      Arita K, Hotokezaka H, Hashimoto M, Nakano-Tajima T, Kurohama T, Kondo T, Darendeliler MA, Yoshida N.
    • Journal Title

      Orthodontics and Craniofacial Research

      Volume: 19 Issue: 2 Pages: 83-92

    • DOI

      10.1111/ocr.12117

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increasing the amount of corticotomy does not affect orthodontic tooth movement or root resorption, but accelerates alveolar bone resorption in rats2016

    • Author(s)
      Kurohama T, Hotokezaka H, Hashimoto M, Tajima T, Arita K, Kondo T, Ino A, Yoshida N
    • Journal Title

      Eur J Orthod

      Volume: 38 Pages: 277-286

    • DOI

      10.1093/ejo/cjw038

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス顎運動の特徴―6自由度顎運動および筋電図同期計測システムを用いて―2019

    • Author(s)
      1.森内絵美, 林田佳央理, 山田佳奈, 安田豪, 吉見知子, 藤下あゆみ, 濱中僚, 古賀義之, 吉田教明
    • Organizer
      第78回日本矯正歯科学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] モーションキャプチャーを用いた6自由度顎運動と筋電図の同期計測による顎口腔機能解析2019

    • Author(s)
      2.安田豪,山田佳奈,森内絵美,吉見知子,藤下あゆみ,濱中僚,小原悠,古賀義之,吉田教明
    • Organizer
      日本顎口腔機能学会第62回学術大会プログラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Coordination of masticatory muscles and jaw movement in six-degrees of freedom depending on food texture during mastication in mice2018

    • Author(s)
      Yoshimi T, Yasuda G, Moriuchi E, Fujishita A, Kohara H, Hamanaka R, Koga Y, Yoshida N
    • Organizer
      The 11th Asian Pacific Orthodontic Conference
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] The effect of masseter muscle hypofunction on experimental tooth movement in rats2018

    • Author(s)
      Arizono K, Hotokezaka H, Morita Y, Kiliaridis S, Yoshida N
    • Organizer
      93rd Congress of the European Orthodontic Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lithium chloride affects tooth root movement and reduces root resorption by orthodontic force in rats2018

    • Author(s)
      3.Ino-Kondo A, Hotokezaka H, Kondo T, Hotokezaka Y, Yoshida N
    • Organizer
      93rd Congress of the European Orthodontic Society
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 6自由度顎運動計測システムを用いた異なる性状の食品咀嚼時のマウス顎運動解析2018

    • Author(s)
      4.藤下あゆみ, 山田佳奈, 安田豪, 森内絵美, 吉見知子, 小原悠, 濱中僚, 古賀義之, 吉田教明
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 咀嚼筋機能低下が歯の移動に与える影響について2018

    • Author(s)
      5.有薗ケイラ,佛坂斉祉,森田幸子,近藤崇伸,近藤愛理,吉見知子,吉見圭子,吉田教明
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Coordination of masticatory muscles and jaw movement in six-degrees of freedom depending on food texture during mastication in mice2018

    • Author(s)
      2.Yoshimi T, Yasuda G, Moriuchi E, Fujishita A, Kohara H, Hamanaka R, Koga Y, Yoshida Y
    • Organizer
      The 11th Asian Pacific Orthodontic Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] モーションキャプチャーを用いた6自由度顎運動計測システムの改良と測定精度2017

    • Author(s)
      3.安田豪、森内絵美、吉見知子、藤下あゆみ、小原悠、濱中僚、古賀義之、吉田教明
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] モーションキャプチャーを応用した6自由度顎運動計測システムを用いた多点同時解析2016

    • Author(s)
      森内絵美,吉見知子,藤下あゆみ,中村文,小原悠,濱中僚,古賀義之,吉田教明
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
  • [Presentation] モーションキャプチャーを用いた小動物6自由度顎運動解析システムの開発2016

    • Author(s)
      森内 絵美,吉見 知子,藤下 あゆみ,中村 文,濱中 僚,古賀 義之,吉田 教明
    • Organizer
      日本顎口腔機能学会第56 回学術大会
    • Place of Presentation
      東洋大学川越キャンパス7号館(埼玉県川越市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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