Human genome analysis for impacted supernumerary teeth in the region of maxillary incisor

• Project/Area Number: 16K15843
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Showa University
• Principal Investigator: Yamaguchi Tetsutaro 昭和大学, 歯学部, 准教授 (40384193)
• Co-Investigator(Kenkyū-buntansha): 高橋 正皓 昭和大学, 歯学部, 助教 (10736713)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 過剰歯 / 遺伝子 / 全エクソンシーケンス / 家系 / ゲノム / ヒト

Outline of Final Research Achievements

One of the popular disorders commonly found in human dentition is the existence of supernumerary teeth. In the present study, we conducted whole-exome sequencing of supernumerary teeth in non-syndromic Japanese individuals to identify the susceptible genes and / or loci. In this study, we selected four Japanese families, two families with the first and the second generation have supernumerary teeth and the other two families have the second generation only with supernumerary teeth. Moreover, 14 sporadic Japanese individuals with impacted supernumerary teeth in the maxillary incisor area were included in the sample. We identified some candidate genes for supernumerary teeth in Japanese individuals.

Research Products

• [Int'l Joint Research] Pusan National University(韓国)
• [Int'l Joint Research] Suez Canal University(エジプト)
• [Journal Article] Interferon regulatory factor 6 variants affect nasolabial morphology in East Asian populations (2018)
  • Author(s): Tomita Daisuke、Yamaguchi Tetsutaro、Nakawaki Takatoshi、Hikita Yu、Adel Mohamed、Kim Yong-Il、Haga Shugo、Takahashi Masahiro、Kawaguchi Akira、Isa Mutsumi、Park Soo-Byung、Ishida Hajime、Maki Koutaro、Kimura Ryosuke
  • Journal Title: Archives of Oral Biology Volume: 85 Pages: 142-147
  • DOI: 10.1016/j.archoralbio.2017.10.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals (2017)
  • Author(s): Takahashi M, Hosomichi K, Yamaguchi T, Yano K, Funatsu T, Adel M, Haga S, Maki K, Tajima A
  • Journal Title: Hum Genome Variation Volume: 印刷中 Issue: 1 Pages: 16046-16046
  • DOI: 10.1038/hgv.2016.46
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contribution of FGFR1 Variants to Craniofacial Variations in East Asians (2017)
  • Author(s): Adel Mohamed、Yamaguchi Tetsutaro、Tomita Daisuke、Nakawaki Takatoshi、Kim Yong-Il、Hikita Yu、Haga Shugo、Takahashi Masahiro、Nadim Mohamed A.、Kawaguchi Akira、Isa Mutsumi、El-Kenany Walid H.、El-Kadi Abbadi A.、Park Soo-Byung、Ishida Hajime、Maki Koutaro、Kimura Ryosuke
  • Journal Title: PLOS ONE Volume: 12 Issue: 1 Pages: e0170645-e0170645
  • DOI: 10.1371/journal.pone.0170645
  • NAID: 120006891154
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive genetic exploration of selective tooth agenesis of mandibular incisors by exome sequencing (2017)
  • Author(s): Yamaguchi T, Hosomichi K, Yano K, Kim Y, Nakaoka H, Kimura R, Otsuka H, Nonaka N, Haga S, Takahashi M, Shirota T, Kikkawa Y, Yamada A, Kamijo R, Park SB, Nakamura M, Maki K, Inoue I
  • Journal Title: Hum Genome Variation Volume: 印刷中 Issue: 1 Pages: 17005-17005
  • DOI: 10.1038/hgv.2017.5
  • NAID: 120006891152
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of the root apex position of impacted maxillary canines on panoramic films (2017)
  • Author(s): Kim SH, Son WS, Yamaguchi T, Maki K, Kim SS, Park SB, Kim YI
  • Journal Title: Am J Orthod Dentofacial Orthop Volume: 152 Issue: 4 Pages: 489-493
  • DOI: 10.1016/j.ajodo.2017.01.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Growth hormone receptor gene variant and three-dimensional mandibular morphology. (2016)
  • Author(s): Nakawaki, T., T. Yamaguchi, M. Isa, A. Kawaguchi, D. Tomita, Y. Hikita, Y. Suzuki-Tomoyasu, M. Adel, H. Ishida, K. Maki, and R. Kimura
  • Journal Title: The Angle Orthodontist Volume: 87(1) Issue: 1 Pages: 68-73
  • DOI: 10.2319/02316-154.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 成長ホルモン受容体（GHR）遺伝子多型と三次元的に解析した下顎骨形態との関連 (2017)
  • Author(s): 中脇貴俊、山口徹太郎、冨田大介、疋田悠、鈴木洋子、Mohamed Adel、方山光朱、木村亮介、槇宏太郎
  • Organizer: 第27回日本顎変形症学会
• [Presentation] Williams症候群の5歳から24歳の治療経過の一例 (2017)
  • Author(s): 山口徹太郎、代田達夫、芳賀秀郷、中島美里、降旗真由、高橋正皓、長濱諒、相原のぞみ、槇宏太郎
  • Organizer: 第27回日本顎変形症学会
• [Presentation] 口唇口蓋裂患者の骨成熟度評価のための統計的形状解析 (2017)
  • Author(s): 山口徹太郎、芳賀秀郷、中島美里、降旗真由、高橋正皓、長濱諒、相原のぞみ、槇宏太郎
  • Organizer: 第27回日本顎変形症学会