| Project/Area Number |
16K15843
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 正皓 昭和大学, 歯学部, 助教 (10736713)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 過剰歯 / 遺伝子 / 全エクソンシーケンス / 家系 / ゲノム / ヒト |
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| Outline of Final Research Achievements |
One of the popular disorders commonly found in human dentition is the existence of supernumerary teeth. In the present study, we conducted whole-exome sequencing of supernumerary teeth in non-syndromic Japanese individuals to identify the susceptible genes and / or loci. In this study, we selected four Japanese families, two families with the first and the second generation have supernumerary teeth and the other two families have the second generation only with supernumerary teeth. Moreover, 14 sporadic Japanese individuals with impacted supernumerary teeth in the maxillary incisor area were included in the sample. We identified some candidate genes for supernumerary teeth in Japanese individuals.
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