| Project/Area Number |
16K15853
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Amano Atsuo 大阪大学, 歯学研究科, 教授 (50193024)
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| Co-Investigator(Kenkyū-buntansha) |
竹内 洋輝 大阪大学, 歯学研究科(研究院), 助教 (40572186)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Porphyromonas gingivalis / 歯周病 / 細胞内寄生 / Rab14 / RalA / VAMP2 / VAMP２ / 細菌の細胞侵入 / メンブレントラフィック |
|---|
| Outline of Final Research Achievements |
Porphyromonas gingival, a periodontal pathogen, is well known to invade host cells such as gingival epithelial cells. However, its intercellular dynamics is unknown. The present study indicated its intracellular trafficking. P. gingivalis was first internalized with early endosomes positive for Rab14 and RalA which are members of low molecular weitht GTP-binding proteins. Then, the intercellular pathogen was suggested to exploit these effector molecules for its intracellular inhabiting and exit from infected cells.
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