| Project/Area Number |
16K15858
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
Yaegaki Ken 日本歯科大学, 生命歯学部, 教授 (40166468)
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| Co-Investigator(Kenkyū-buntansha) |
田中 とも子 日本歯科大学, 生命歯学部, 准教授 (70307958)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バイオフィルム / 歯肉溝 / 歯周病 / 歯周疾患 / Red complex / 前臨床研究 / Red Complex / 歯肉上皮 / in vitro |
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| Outline of Final Research Achievements |
The purpose of this study is how to establish a gingival sulcus model by reclaimed gums and to drive the pre-clinical study.
The microorganisms were Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Streptococcus gordonii. We tried biofilm formation on the section of a human tooth with the TYGVS culture medium added N-acetylmuramic acid. The biofilm formation was confirmed by the SEM observation and the bacterial flora analyses.
And the stem cells segregation became a simple method by the magnetic separation. But reproduction of an artificial gingival sulcus didn't come to realization.
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