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The trial of clarification of the mechanism of salivary hypofunction involved in cancer therapies and development the care for protection of salivary glands by producing a model mouse.

Research Project

Project/Area Number 16K15863
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fundamental nursing
Research InstitutionYamagata University

Principal Investigator

Sekimata Akiko  山形大学, 医学部, 准教授 (50321823)

Co-Investigator(Kenkyū-buntansha) 関亦 正幸  福島県立医科大学, 医学部, 准教授 (80250190)
野川 宏幸  千葉大学, 大学院理学研究院, 准教授 (40143250)
Research Collaborator NOGAWA Hiroyuki  
INOUE Naokazu  
YOSHIDA Daiki  
HAYASAKA Yuto  
SUINA Yumi  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords唾液腺 / 唾液分泌低下 / 放射線療法 / がん化学療法 / がん支持療法 / 口腔トラブル / 耳下腺 / アミラーゼ / 唾液分泌 / 初代培養細胞 / 遺伝子改変マウス / 有害事象予防ケア / 唾液線体外培養
Outline of Final Research Achievements

Hyposalivation as a consequence of cancer therapies is the significant complication, because hyposalivation causes various side effects such as oral trouble, reducing illness motivation, including danger of life. This study aimed at clarification of the mechanism of salivary hypofunction involved in cancer therapies and development the care for protection of salivary glands, by producing a transgenic mouse introduced Venus gene which is enabled visualization and quantification of saliva secretion. We successfully produced the transgenic mouse and in vitro salivary gland culture-systems in this study. In future, we would like to contribute to the development of supporting treatments for cancer therapies by the identification of protectants for salivary glands and promoters for saliva secretion using the transgenic mouse and the culture systems.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Morphogenesis and Mucus Production of Epithelial Tissues of Three Major Salivary Glands of Embryonic Mouse in 3D Culture2017

    • Author(s)
      Azusa Nakao , Takumi Inaba , Akiko Murakami-Sekimata and Hiroyuki Nogawa
    • Journal Title

      Zoological Science

      Volume: 34 Issue: 6 Pages: 475-483

    • DOI

      10.2108/zs160177

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] マウス胎児唾液腺上皮組織の体外培養におけるneuregulin1とfibroblast growth factor1の細胞分化への作用2016

    • Author(s)
      早坂勇人,野川宏幸,関亦正幸,関亦明子
    • Journal Title

      山形医学

      Volume: 34 Pages: 42-49

    • NAID

      120005830692

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] インターロイキン9 (IL9)遺伝子サイレンサーと転写因子Runx1によるエピジェネティックなIL9転写調節機構の解明2017

    • Author(s)
      吉田大貴,関亦明子, 伊関憲,関亦正幸
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 唾液腺保護ケア開発を目指したマウス唾液腺培養モデル構築の試みにおけるSerum Replacementの効果について2017

    • Author(s)
      関亦明子, 阿蘓祐子, 推名祐美, 本間千明, 柳橋志帆,関亦正幸
    • Organizer
      第5回 看護理工学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス胎児顎下腺原基上皮細胞の無血清培地による単層化培養の試み2017

    • Author(s)
      関亦明子,野川宏幸,関亦正幸
    • Organizer
      第90回 日本組織培養学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] STARR-seq法で同定したエンハンサーと転写因子Runx1によるエピジェネティックなIL-22遺伝子発現調節機2016

    • Author(s)
      関亦正幸,伊関憲,関亦明子
    • Organizer
      第39回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 唾液腺保護ケアの開発を目指したマウス胎児唾液腺単層化培養の試み2016

    • Author(s)
      関亦明子,野川宏幸,関亦正幸
    • Organizer
      第4回 看護理工学会学術集会
    • Place of Presentation
      岩手県立大学(岩手)
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス胎児顎下腺上皮組織の体外培養におけるneuregulin 1とfibroblast growth factor 1の細胞分化への作用2016

    • Author(s)
      関亦明子,早坂勇人,野川宏幸,関亦正幸
    • Organizer
      第89回 日本組織培養学会大会
    • Place of Presentation
      千里ライフサイエンスセンター (大阪)
    • Year and Date
      2016-05-25
    • Related Report
      2016 Research-status Report
  • [Remarks] 感染防御・遺伝科学 研究概要

    • URL

      http://www.n-yu.jp/kansenbougyo/index.php?%E7%A0%94%E7%A9%B6%E6%A6%82%E8%A6%81

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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