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Development of care program analyzing autonomic nervous function in cancer patients.

Research Project

Project/Area Number 16K15903
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Clinical nursing
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Yamanaka Ryuya  京都府立医科大学, 医学部, 教授 (20323991)

Co-Investigator(Kenkyū-buntansha) 早野 あづさ  京都府立医科大学, 医学(系)研究科(研究院), 研究員 (10379018)
川口 淳  佐賀大学, 医学部, 教授 (60389319)
吉岡 さおり  京都府立医科大学, 医学部, 准教授 (60454881)
岩脇 陽子  京都府立医科大学, 医学部, 教授 (80259431)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsがん患者 / 自律神経機能 / ケアプログラム / 心理学的変化 / 看護ケア / 臨床 / 癌 / 脳神経 / 生理学
Outline of Final Research Achievements

The objective of this study was to assess, using physiological and psychological indices, the effects of mechanical bathing care for patients in the terminal stage of cancer. The heart rate variability analysis method was used to measure autonomic nervous system function. The patients' state of anxiety was assessed using the State-Trait Anxiety Inventory (STAI), a psychological index, and patients' verbal responses were also collected after mechanical bathing.Twenty-four patients were enrolled in this study. Their sympathetic and parasympathetic nervous activity did not differ before and after bathing. A significant difference was found between pre- and post-bathing anxiety, as evaluated by STAI (P < 0.0001). Patients were more relaxed after mechanical bathing according to STAI evaluation and their verbal responses.The findings suggest that the method of bathing used in this study is safe and pain-relieving for terminal stage cancer patients.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (37 results)

All 2018 2017 2016 Other

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 23 results,  Open Access: 5 results) Presentation (9 results) (of which Int'l Joint Research: 3 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Frequency and risk factors for subsyndromal delirium in an intensive care unit2018

    • Author(s)
      Yamada Chikayo、Iwawaki Yoko、Harada Kiyomi、Fukui Michihiko、Morimoto Masafumi、Yamanaka Ryuya
    • Journal Title

      Intensive and Critical Care Nursing

      Volume: 47 Pages: 15-22

    • DOI

      10.1016/j.iccn.2018.02.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between lower balance of Th2 helper T-cells and expression of PD-L1/PD-1 axis genes enables prognostic prediction in patients with glioblastoma2018

    • Author(s)
      Takashima Yasuo、Kawaguchi Atsushi、Kanayama Tomohiko、Hayano Azusa、Yamanaka Ryuya
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 27 Pages: 19065-19078

    • DOI

      10.18632/oncotarget.24897

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma.2018

    • Author(s)
      Takashima Y, Sasaki Y, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Tokino T, Yamanaka R.
    • Journal Title

      Oncotarget

      Volume: in press

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The expression of PD-1 ligands and IDO1 by macrophages/microglia in primary central nervous system lymphoma.2018

    • Author(s)
      Miyasato Y, Takashima Y, Takeya H, Yano H, Hayano A, Nakagawa T, Makino K, Takeya M, Yamanaka R, Komohara Y.
    • Journal Title

      Journal of Clinical and Experimental Hematopatholgy

      Volume: in press

    • NAID

      130007403913

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late relapse of primary central nervous system lymphoma.2017

    • Author(s)
      Yamanaka R, Morii K, Shinbo Y, Sano M, Homma J, Tsuchiya N, Yajima N, Tsukamoto Y, Ogura R,Natsumeda M, Aoki H, Akiyama K, Saitoh T, Tamura T, Hondoh H, Kawaguchi A, Takahashi H, and Fujii Y.
    • Journal Title

      Leukemia Lymphoma

      Volume: 58 Pages: 475-477

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term survivors of primary central nervous system lymphoma.2017

    • Author(s)
      Yamanaka R, Morii K, Sano M, Homma J, Yajima N, Tsukamoto Y, Ogura R, Natsumeda M, Aoki H, Akiyama K, Saitoh T, Hondoh H, Kawaguchi A, Takahashi H, Fujii Y.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 47 Issue: 2 Pages: 101-107

    • DOI

      10.1093/jjco/hyw171

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anxiety in cancer patients receiving outpatient chemotherapy based on their employment status-improving patient support.2017

    • Author(s)
      Tamura S, Mitsuki S, Yamanaka R.
    • Journal Title

      Cepal Review

      Volume: March Pages: 2819-2827

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stat3 inhibitor abrogates the expression of PD-1 ligands on lymphoma cell lines2017

    • Author(s)
      Ma C, Horlad H, Pan C, Yano H, Ohnishi K, Fujiwara Y, Matsuoka M, Lee A, Niidome T, Yamanaka R, Takeya M, Komohara Y
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 57 Issue: 1 Pages: 21-25

    • DOI

      10.3960/jslrt.17006

    • NAID

      130005709510

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects and safety of mechanical bathing as a complementary therapy for terminal stage cancer patients from the physiological and psychological perspective: a pilot study2017

    • Author(s)
      Fujimoto Sawako、Iwawaki Yoko、Takishita Yukie、Yamamoto Yoko、Murota Masako、Yoshioka Saori、Hayano Azusa、Hosokawa Toyoshi、Yamanaka Ryuya
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 47 Issue: 11 Pages: 1066-1072

    • DOI

      10.1093/jjco/hyx122

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Programmed Cell Death Ligand 1 Expression in Primary Central Nervous System Lymphomas: A Clinicopathological Study.2017

    • Author(s)
      Hayano A, Komohara Y, Takashima Y, Takeya H, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H and Yamanaka R.
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 5655-5666

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secondary glioma following acute lymphocytic leukemia: Therapeutic implications.2017

    • Author(s)
      Yamanaka R, Hayano A
    • Journal Title

      Neurosurg Rev

      Volume: 40 Issue: 4 Pages: 549-557

    • DOI

      10.1007/s10143-016-0733-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced meningiomas: an exhaustive review of the literature.2017

    • Author(s)
      Yamanaka R, Hayano A, Kanayama T
    • Journal Title

      World Neurosurg

      Volume: 97 Pages: 635-644

    • DOI

      10.1016/j.wneu.2016.09.094

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced sarcomas of the central nervous system: a systematic review.2017

    • Author(s)
      Yamanaka R, Hayano A
    • Journal Title

      World Neurosurg

      Volume: 98 Pages: 818-828

    • DOI

      10.1016/j.wneu.2016.11.008

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secondary craniofacial sarcomas following retinoblastoma: a systematic review.2017

    • Author(s)
      Yamanaka R, Hayano A
    • Journal Title

      World Neurosurg

      Volume: in press Pages: 722-730

    • DOI

      10.1016/j.wneu.2017.02.031

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiation-Induced Schwannomas and Neurofibromas: A Systematic Review2017

    • Author(s)
      Yamanaka Ryuya、Hayano Azusa
    • Journal Title

      World Neurosurgery

      Volume: 104 Pages: 713-722

    • DOI

      10.1016/j.wneu.2017.05.066

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation-Induced Malignant Peripheral Nerve Sheath Tumors: A Systematic Review2017

    • Author(s)
      Yamanaka Ryuya、Hayano Azusa
    • Journal Title

      World Neurosurgery

      Volume: 105 Pages: 961-970

    • DOI

      10.1016/j.wneu.2017.06.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trilateral retinoblastoma: A systematic review of 211 cases2017

    • Author(s)
      Yamanaka Ryuya、Hayano Azusa、Takashima Yasuo
    • Journal Title

      Neurosurgical Review

      Volume: - Issue: 1 Pages: 39-48

    • DOI

      10.1007/s10143-017-0890-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review2017

    • Author(s)
      Yamanaka Ryuya、Abe Eisuke、Sato Toshiteru、Hayano Azusa、Takashima Yasuo
    • Journal Title

      Cancers

      Volume: 9 Issue: 8 Pages: 103-103

    • DOI

      10.3390/cancers9080103

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiation-induced schwannomas and neurofibromas: a systematic review.2017

    • Author(s)
      Yamanaka R, Hayano A
    • Journal Title

      World Neurosurg

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anxiety in cancer patients receiving outpatient chemotherapy based on their employment status-improving patient support.2017

    • Author(s)
      Tamura S, Mitsuki S, Yamanaka R
    • Journal Title

      Cepal Review

      Volume: 122 Pages: 1-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of S-phase fractions in peritumoral invading zone analyzed by laser scanning cytometry in patients with high-grade glioma (preliminary study).2016

    • Author(s)
      Nakajima S, Morii K, Takahashi H, Fujii Y, Yamanaka R
    • Journal Title

      ONCOLOGY LETTERS

      Volume: 11 Pages: 2106-2110

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secondary glioma following acute lymphocytic leukemia: Therapeutic implications.2016

    • Author(s)
      Yamanaka R, Hayano A
    • Journal Title

      Neurosurg Rev

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Radiation-induced gliomas: A comprehensive review and meta-analysis.2016

    • Author(s)
      Yamanaka R, Hayano A, Kanayama T
    • Journal Title

      Neurosurg Rev

      Volume: in press

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship Between Stress and Saliva Biomarkers in Breast Cancer Patients Receiving Outpatient Chemotherapy2018

    • Author(s)
      Tamura S, Hayama Y, Mitsuki S, Sakaguchi K, Yamanaka R.
    • Organizer
      he Asian Conference on Psychology & The Behavioral Sciences.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anxiety and return to work in breast cancer patients receiving outpatient chemotherapy.2017

    • Author(s)
      Tamura S, Mitsuki S, Sakaguchi K, Yamanaka R.
    • Organizer
      The Asian Conference on Psychology & The Behavioral Sciences.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 終末期がん患者に対する機械浴の生理的・心理的な影響についての予備的研究.2017

    • Author(s)
      藤本 早和子, 岩脇 陽子, 滝下 幸栄, 山本 容子, 室田 昌子, 吉岡 さおり, 細川 豊史, 山中 龍也
    • Organizer
      第22回日本緩和医療学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳リンパ腫の長期生存例の検討2017

    • Author(s)
      山中龍也、早野あづさ、藤井幸彦
    • Organizer
      第15回日本臨床腫瘍学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 中枢神経原発悪性リンパ腫の統合的解析2017

    • Author(s)
      吉田健一、越智陽太郎、白石友一、磯部知弥、千葉健一、田中洋子、岡田愛、早野あづさ、奥野友介、鈴木啓道、宮野悟、山中 龍也、小川誠司
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳原発および転移性脳悪性リンパ腫におけるProgrammed Cell Death Ligand 1発現の検討.2017

    • Author(s)
      早野あづさ、菰原義宏、高島康郎、本間順平、深井順也、岩立康男、梶原浩司、石澤伸、本道洋昭、山中龍也.
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] がん免疫療法のターゲットとなる分子と予後との関連の解析.2017

    • Author(s)
      高島康郎、川口淳、金山知彦、早野あづさ、山中龍也
    • Organizer
      第40回日本分子生物学会年会,
    • Related Report
      2017 Annual Research Report
  • [Presentation] Whole-Genome Sequencing of Primary Central Nervous System Lymphoma and Diffuse Large B-Cell Lymphoma.2016

    • Author(s)
      Yoshida K, Yamanaka R and Ogawa S et al.
    • Organizer
      58th ASH Annual Meeting and Exposition.
    • Place of Presentation
      San diego, CA, USA
    • Year and Date
      2016-12-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中枢神経原発悪性リンパ腫におけるゲノム異常の全貌2016

    • Author(s)
      吉田健一、千葉健一、奥野友介、垣内伸之、鈴木啓道、白石友一、田中洋子、村垣善浩、椎名隆、宮野悟、千葉滋、山中 龍也、小川誠司
    • Organizer
      第75回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Book] Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes2016

    • Author(s)
      Kanayama T, Hayano A, Yamanaka R
    • Total Pages
      298
    • Publisher
      Nova Science Publishers
    • Related Report
      2016 Research-status Report
  • [Book] Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes2016

    • Author(s)
      Yamanaka R
    • Total Pages
      298
    • Publisher
      Nova Science Publishers
    • Related Report
      2016 Research-status Report
  • [Book] Primary Central Nervous System Lymphoma (PCNSL): Incidence, Management and Outcomes2016

    • Author(s)
      Yamanaka R, Yoshioka S, Fujimoto S, Iwawaki Y
    • Total Pages
      298
    • Publisher
      Nova Science Publishers
    • Related Report
      2016 Research-status Report
  • [Remarks] 京都府医科大学 保健看護学研究科 医学講座HP

    • URL

      http://www.f.kpu-m.ac.jp/c/kouza/igaku/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 腫瘍分子標的治療学講座HP

    • URL

      http://www.f.kpu-m.ac.jp/c/kouza/igaku/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-12-27  

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