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Twin studies on Tojikomori syndrome in Japanese elderly

Research Project

Project/Area Number 16K15978
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gerontological nursing
Research InstitutionKio University

Principal Investigator

INUI FUJIO  畿央大学, 健康科学部, 准教授 (80469551)

Co-Investigator(Kenkyū-buntansha) 冨澤 理恵  大阪大学, 医学系研究科, 特任講師(常勤) (20584551)
本多 智佳  大阪大学, 医学系研究科, 特任准教授(常勤) (40625498)
加藤 憲司  神戸市看護大学, 看護学部, 教授 (70458404)
中谷 香江  畿央大学, 健康科学部, 助手 (20524979)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords行動遺伝学 / 双生児研究法 / うつ症状 / 疲労 / 自己効力感 / 睡眠時間 / 双生児研究 / 遺伝環境交互作用 / うつ / 閉じこもり
Outline of Final Research Achievements

We conduct the cohort study on middle-aged twins, which has been held every two years since 2008, for investigate depressive symptoms, self-efficacy, lifestyle (including sleeping, eating, living environment), working style, fatigue scale. As a result, the relations between self-efficacy, fatigue, and depressive symptoms were explained by two different genetic factors-a genetic factor related to self-efficacy, fatigue, and depressive symptoms. However, there is another genetic factor that is not associated with self-efficacy.
On sleep duration, we investigated genetic and environmental factors. No evidence was found for the influence of genetic effects on sleep duration in the Japanese population. Instead, common environmental factors explained 44% of the variation of sleep duration. However, it is presumed that some significant environmental factors influence it.

Academic Significance and Societal Importance of the Research Achievements

自己効力感は従来は疾患からの回復に関係すると考えられていた。しかし,身体症状や精神症状そのものと共通する遺伝要因が確認できたことは,疾患の発症メカニズムを解明する上で有用な知見をもたらす。また,今回の結果だけでは明確ではないが,日本人の睡眠時間の分散に影響を与える遺伝要因が極めて小さいことは,遺伝要因が小さいのではなく,それよりもより大きな環境要因が作用していると解釈できる。このことは,日本における近年の睡眠時間の減少が将来的に心身に大きな影響をもたらす可能性を示している。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2017 Research-status Report
  • [Journal Article] Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts2018

    • Author(s)
      Piirtola Maarit、Jelenkovic Aline、Latvala Antti、Sund Reijo、Honda Chika、Inui Fujio、Watanabe Mikio、et al., Silventoinen Karri
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: e0200140-e0200140

    • DOI

      10.1371/journal.pone.0200140

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts2017

    • Author(s)
      Silventoinen Karri、Jelenkovic Aline、et al.
    • Journal Title

      Twin Research and Human Genetics

      Volume: 20 Issue: 5 Pages: 395-405

    • DOI

      10.1017/thg.2017.49

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts2017

    • Author(s)
      Silventoinen Karri、Jelenkovic Aline、et al.
    • Journal Title

      The American Journal of Clinical Nutrition

      Volume: 106 Issue: 2 Pages: 457-466

    • DOI

      10.3945/ajcn.117.153643

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 健康科学における双生児研究法(Twin study)の可能性について2016

    • Author(s)
      乾富士男
    • Journal Title

      畿央大学紀要

      Volume: 13 Pages: 1-8

    • NAID

      40021052862

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] No Evidence was Found for the Influence of Genetic Effects on Sleep Duration in the Japanese Population2019

    • Author(s)
      Fujio Inui, Karri Silventoinen, Chika Honda, Rie Tomizawa, Daisuke Matsumoto, Kae Nakatani, Norio Sakai
    • Organizer
      49th Behavior Genetics Association ANNUAL MEETING
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自己効力感と疲労およびうつ症状の関連について2018

    • Author(s)
      乾富士男,Karri Silventoinen,本多智佳,冨澤理恵,酒井則夫,中谷香江,松本大輔,加藤憲司,大阪ツインリサーチグループ
    • Organizer
      日本双生児研究学会第32回学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Genetic and environmental associations between self-efficacy, fatigue and depression.2017

    • Author(s)
      Fujio Inui, Karri Silventoinen, Chika Honda, Rie Tomizawa, Norio Sakai, Kae Nakatani, Daisuke Matsumoto, Kenji Kato, Osaka Twin Research Group
    • Organizer
      Twins2017 (ISTS congress), Madrid
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Genetic and environmental associations between self-efficacy and depressive symptoms in a Japanese population.2016

    • Author(s)
      F.Inui, K.Silventoinen, C.Honda,et al.
    • Organizer
      The 16th International Congress on Twin Studies 2016
    • Place of Presentation
      Brisbane
    • Year and Date
      2016-06-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] 研究室について

    • URL

      https://bg-lab.org/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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