Regulation of the quality of the bone structure by B vitamins for prevention of osteoporotic fracture and analysis of the bone strength factor

• Project/Area Number: 16K15980
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gerontological nursing
• Research Institution: Fukuoka College of Health Sciences
• Principal Investigator: Nakazono Eri 福岡医療短期大学, 保健福祉学科, 講師 (10343732)
• Co-Investigator(Kenkyū-buntansha): 大倉 義文 一般財団法人ファジィシステム研究所, 研究部, 主席研究員 (80352293)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ビタミンB群 / 骨強度 / 高齢者 / 食事指導 / 骨質 / 定量的超音波法 / ホモシステイン / ビタミンＢ群 / 医療・福祉 / 栄養学 / 看護学

Outline of Final Research Achievements

This study aimed to analyze the relevance to B vitamins (vitamin B6, B12, folic acid), bone quality and bone strength factors. The subjects were elderly women. Subjects divided into two groups: intervention group that intake of food high in B vitamins and control group. Two groups were followed up at 9 months. Bone strength was evaluated by osteo sono-assessment index (OSI).In baseline, OSI was not associated with serum bone metabolic marker, homocysteine, vitamin B6, B12 and folic acid. However, dietary intake of vitamin B6, B12 and folic acid were showed a positive correlation with OSI.At nine months later, the control group was significantly decreased in OSI, but the intervention group did not change. OSI was associated with dietary intake of vitamin B6 and vitamin B12.
In this study, it was suggested that intake of the B vitamins was helpful to maintain the bone strength in the elderly women.

Academic Significance and Societal Importance of the Research Achievements

ビタミンＢ群高摂取の介入群は、コントロール群を比較して骨強度が減少せず維持していた。ビタミンB群摂取が、高齢女性の骨強度の維持に役立つことが示唆されたことは、高齢看護学における、食生活指導による在宅での骨粗鬆症性骨折予防への応用が期待できる。

Research Products

• [Presentation] 自立した生活をする高齢者のビタミンDとB12、葉酸の血中濃度及び栄養素摂取状況と骨強度との関連 (2018)
  • Author(s): 中園栄里，末松美保子，齊田直樹，大倉義文
  • Organizer: 第65回日本栄養改善学会学術総会
• [Presentation] 転倒予防は食にあり (2016)
  • Author(s): 中園 栄里
  • Organizer: 第15回福岡医療短期大学公開講座
  • Place of Presentation: 福岡
  • Year and Date: 2016-10-02
  • Invited