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Twin study for genetic and environmental influence on osteoporosis: Japan and international comparison

Research Project

Project/Area Number 16K15989
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Community health nursing
Research InstitutionOsaka University

Principal Investigator

Honda Chika  大阪大学, 医学系研究科, 特任准教授(常勤) (40625498)

Co-Investigator(Kenkyū-buntansha) 冨澤 理恵  大阪大学, 医学系研究科, 特任講師(常勤) (20584551)
乾 富士男  畿央大学, 健康科学部, 准教授 (80469551)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords双生児研究 / 公衆衛生 / 地域保健 / 公衆衛生看護 / 公衆衛生学 / 疫学 / 看護学
Outline of Final Research Achievements

In the current study, we collected the bone health data from Japanese female adult twins and analyzed to investigate how genetic and environmental factors influence bone health. It showed that the variance of bone mineral density was explained by genetic factors more than environmental factors. We also compared the result from European data and found that greater influence of genetic factors in the Japanese population than in Europeans. This may indicate that genetic factors play a more significant role and result in higher prevalence of osteoporosis in Japanese female population

Academic Significance and Societal Importance of the Research Achievements

骨粗鬆症は健康寿命と平均寿命の差を生む重要な要因の一つでもあるが日本人、特に女性において骨粗鬆の有病率は諸外国に比べて高いことが指摘されている。本研究では、日本人における骨密度測定結果において遺伝的要因が環境要因より大きい可能性が示唆されたとともに、欧州のデータとの比較から、遺伝的要因がより強い可能性が示された。今後は長期的な調査とゲノム背景を考慮した上で環境要因の影響をより正確に検討出来る研究に発展させたいと考える。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2018 Other

All Int'l Joint Research (12 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Int'l Joint Research] センメルヴェイス大学(ハンガリー)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] サンタクルス病院研究所(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Santa Cruz Hospital(ブラジル)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University of Helsinki(フィンランド)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Semelweiss University(ハンガリー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] ヘルシンキ大学(フィンランド)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] センメルワイス医科大学(ハンガリー)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] 南デンマーク大学(デンマーク)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] メルボルン大学(オーストラリア)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] 南カリフォルニア大学(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2017 Research-status Report
  • [Journal Article] Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts2018

    • Author(s)
      Piirtola Maarit、Jelenkovic Aline、Latvala Antti、Sund Reijo、Honda Chika、Inui Fujio、Watanabe Mikio、et al., Silventoinen Karri
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: e0200140-e0200140

    • DOI

      10.1371/journal.pone.0200140

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 日本とハンガリーの成人双生児における骨密度の遺伝寄与率2018

    • Author(s)
      佐伯壮一朗, 本多智佳, 南谷かおり, 田畑知沙, 中谷大作, 冨澤理恵,大阪ツインリサーチグループ, Adam L. Jermendy, Gyorgy Jermendy, Bela Merkely, Pal Maurovich-Horvat, Adam D. Tarnoki, David L Tarnoki, 酒井規夫, 中田研
    • Organizer
      第33回 日本双生児研究学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 医学部生の国際共同医学研究参画:日本・ハンガリーのツインリサーチ骨粗鬆症共同研究への取り組み2018

    • Author(s)
      佐伯壮一朗、本多智佳、南谷かおり、田畑知沙、中谷大作、大阪ツインリサーチグループ、酒井規夫、中田研
    • Organizer
      第3回 国際臨床医学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 成人双生児における骨密度と生活習慣の関連について2018

    • Author(s)
      本多智佳,冨澤理恵,赤田加奈子,乾富士男, 大阪ツインリサーチグループ,酒井規夫
    • Organizer
      日本双生児研究学会第32回学術講演会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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