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A system for accelerating large-scale genome analysis

Research Project

Project/Area Number 16K16145
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Life / Health / Medical informatics
Research InstitutionThe University of Tokyo

Principal Investigator

Kasahara Masahiro  東京大学, 大学院新領域創成科学研究科, 准教授 (60376605)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsワークフロー / 再現性 / コンテナ仮想化 / 並列計算 / パイプライン / ゲノム科学 / 並列分散計算 / ハイパフォーマンスコンピューティング / ゲノム解析 / ソフトウエア開発効率化・安定化 / ハイパフォーマンス・コンピューティング / アルゴリズム / ゲノム
Outline of Final Research Achievements

Traditional researches in parallel computing were often geared toward more efficient use of CPU or other units. On the other hand, we usually have to compute only once for findings in natural sciences. Therefore, the main bottleneck in parallel computing in genome analysis is the time for programming, not the time for computation. To this end, we developed (1) composable container system, (2) workflow description system that requires a minimal amount of learning and description of workflows, (3) a system for easily using commercial cloud computing or HPC clusters. Those tools are released under open-source licences.

Academic Significance and Societal Importance of the Research Achievements

ゲノム研究など、数多くのグループ・企業が提供しているソフトウェアを組み合わせて大規模データを解析する発見科学の計算を「(速くではなく)早く」実行するシステムにより各種の研究や開発が大きく加速される。ゲノム研究だけではなく、自然言語処理や深層学習を含む機械学習分野でも類似の問題を抱えており、これらの分野でも研究・開発が加速される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 Other

All Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (5 results)

  • [Presentation] LPMX: Local Package Manager X edition & taw: Tiny Amazon Wrapper2019

    • Author(s)
      Masahiro Kasahara
    • Organizer
      第23回オープンバイオ研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Things that Docker does not Provide for Genome Informatics2018

    • Author(s)
      Masahiro Kasahara
    • Organizer
      Biohackathon 2018 Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A composable container system for genomic analysis pipelines2018

    • Author(s)
      Xu Yang
    • Organizer
      Bioinformatics Open Source Conference 2018 (BOSC2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] Local Package Manager

    • URL

      https://lpm.bio/

    • Related Report
      2018 Annual Research Report
  • [Remarks] Local Package Manager X

    • URL

      https://github.com/JasonYangShadow/lpmx

    • Related Report
      2018 Annual Research Report
  • [Remarks] Tiny Cloud Engine

    • URL

      http://ka.cb.k.u-tokyo.ac.jp/tce/

    • Related Report
      2017 Research-status Report 2016 Research-status Report
  • [Remarks] Local Package Manager

    • URL

      http://lpm.bio/

    • Related Report
      2017 Research-status Report
  • [Remarks] Openwait

    • URL

      https://github.com/mkasa/openwait

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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