| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
One of lifestyle-related diseases, obesity, is also recognized in children in recent years. Epidemiological studies have reported that the harmful chemicals present in the maternal environment act on the fetus through cord blood and lead to adipocytes hypertrophy causing child's obesity. In this study, the risk of chemicals in maternal environment causing adipocyte hypertrophy was evaluated using epigenetic information. Exposure of five chemicals (DEP, Hg, cotinine, Se, S-421) to preadipocytes at maternal serum concentrations resulted in no effect on epigenetic status based on heterochromatin formation. Furthermore, these chemicals did not affect adipocyte differentiation in vitro, suggesting that analyzed five chemicals do not cause adipocyte hypertrophy at maternal serum concentrations. Collectively, a risk of adipocyte hypertrophy caused by analyzed chemicals could be evaluated based on epigenetic information.
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