Dependence of cancer-prone mutation on age at radiation exposure.
| Project/Area Number |
16K16194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology (2017)
Nagasaki University (2016) |
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Principal Investigator |
Sunaoshi Masaaki 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 研究員(定常) (70756030)
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| Research Collaborator |
SHANG Yi 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (50533189)
KAKINUMA Shizuko 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 部長 (20392219)
TSURUOKA Chizuru 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (60415411)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 放射線発がん / マウス胸腺リンパ腫 / 被ばく時年齢 / 遺伝子突然変異 / 被ばく時年齢依存性 / 突然変異 / 細胞競合 / 微小環境 |
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| Outline of Final Research Achievements |
In this study, to clarify the process of radiation lymphomagenesis depending on age at exposure, genetic alterations in thymocytes of mice exposed to radiation at different ages were analyzed from after irradiation until the time of carcinogenesis. As a result, after infant irradiation, unlike after adult irradiation, cells harboring genetic alterations increased in the early phase of carcinogenic process. The pattern of the genetic alterations tended to be different depending on the age at exposure. These results suggested that radiation carcinogenic process might depend on age at exposure. In the future, it is expected that this research can be applied to the estimation of carcinogenic risk and mechanism taking into account the age at radiation exposure.
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Report
(3 results)
Research Products
(4 results)
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[Presentation] Age-dependent thymus regeneration after irradiation may change the initiating cells for radiation-induced lymphomagenesis.2017
Author(s)
Masaaki Sunaoshi, Benjamin J. Blyth, Yi Shang, Chizuru Tsuruoka, Shinobu Sakairi, Takamitsu Morioka, Mayumi Shinagawa, Mari Ogawa, Atsuko Ishikawa, Kazuhiro Daino, Keiji Suzuki, Yoshiya Shimada, Akira Tachibana and Shizuko Kakinuma
Organizer
The 63rd Annual Meeting of the Radiation Research Society
Related Report
Int'l Joint Research
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