Genome instability induced by high-energy phosphate compounds
| Project/Area Number |
16K16195
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Chiba University |
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Principal Investigator |
Sassa Akira 千葉大学, 大学院理学研究院, 特任助教 (10738347)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | DNA修復 / リボヌクレオチド / 損傷乗り越えDNA合成 / ゲノム不安定性 / DNA損傷 / 突然変異 / ゲノム / 酵素 / 遺伝子 / 核酸 |
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| Outline of Final Research Achievements |
Ribonucleotides are essential for cellular metabolism and energy production. On the other hand, ribonucleotides are often incorporated into the genome by DNA polymerases in mammalian cells. The aberrant accumulation of ribonucleotides in the genome causes cellular abnormalities. In this study, we have clarified the mutagenic potential of a ribonucleotide incorporated into DNA and possible alternate repair pathways to suppress the mutagenic effect of an embedded ribonucleotide in human cells.
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| Academic Significance and Societal Importance of the Research Achievements |
リボヌクレオチドのゲノムへの蓄積は、重度心身障害をもたらすAicardi-Goutieres症候群（AGS）の発症や細胞のがん化と深く関連している考えられる。DNAに取り込まれたリボヌクレオチドが誘発するゲノム不安定化とその抑制因子を明らかにすることで、疾患の発症メカニズムならびに生物の新たなゲノム制御機構の解明につながる。
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Report
(5 results)
Research Products
(45 results)
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[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells2019
Author(s)
Akira Sassa, Haruto Tada, Ayuna Takeishi, Kaho Harada, Kazuma Nakatani, Masataka Tsuda, Hiroyuki Sasanuma, Shunichi Takeda, Kaoru Sugasawa, Manabu Yasui, Masamitsu Honma, Kiyoe Ura
Organizer
The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
Related Report
Int'l Joint Research
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[Presentation] Effect of Sugar Backbone on Translesion Synthesis, Repair, and Mutagenic Potential of 7,8-Dihydro-8-oxoguanine2017
Author(s)
Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M, Ura K
Organizer
Environmental Mutagenesis & Genomics Society 48th Annual Meeting
Related Report
Int'l Joint Research
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