Elucidation of useful livestock/poultry for Pb source estimation and its molecular mechanisms underlying species differences by integrated metallomics approaches

• Project/Area Number: 16K16197
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hokkaido University
• Principal Investigator: Nakayama Shouta 北海道大学, 獣医学研究院, 助教 (90647629)
• Research Collaborator: Ishizuka Mayumi 北海道大学, 大学院獣医学研究院, 教授 ; Ikenaka Yoshinori 北海道大学, 大学院獣医学研究院, 准教授 ; Mizukawa Hazuki 北海道大学, 大学院獣医学研究院, 助教 ; Hirata Takafumi 東京大学, 大学院理学系研究科, 教授
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 鉛 / 汚染源推定 / 安定同位体比 / 家畜・家禽 / ヤギ / ニワトリ / 歩哨動物 / LA-ICP-MS / 海馬 / 高感受性部位 / 鉛同位体比 / 動物種差

Outline of Final Research Achievements

According to WHO, approximately 230,000 people annually die mainly from lead (Pb) poisoning derived from mineral deposits and affect the intellectual development of more than 600,000 children, but useful methods for estimating pollution sources have not been established. In this study, we aimed to elucidate useful livestock and poultry species for source estimation of Pb contamination. From the high precision lead isotope ratio analysis, it was revealed that it is possible to estimate the source of Pb contamination by using goats and chickens distributed in developing countries including Africa and also used as human food sources. Local distribution of Pb in mice was analyzed by LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry). High Pb accumulation in the hippocampus area of the brain and Pb accumulation at a higher concentration than in the cortex than the medulla of the kidney was revealed.

Research Products

• [Int'l Joint Research] ザンビア大学(ザンビア)
• [Int'l Joint Research] クワメエンクルマ科学技術大学(ガーナ)
• [Int'l Joint Research] ベニン大学(ナイジェリア)
• [Int'l Joint Research] ノースウェスト大学(南アフリカ)
• [Int'l Joint Research] ゴンダ大学(エチオピア)
• [Int'l Joint Research] ザンビア大学獣医学部(ザンビア)
• [Journal Article] Lead and cadmium excretion in feces and urine of children from polluted townships near a lead-zinc mine in Kabwe, Zambia (2018)
  • Author(s): Yabe John、Nakayama Shouta M.M.、Ikenaka Yoshinori、Yohannes Yared B.、Bortey-Sam Nesta、Kabalo Abel Nketani、Ntapisha John、Mizukawa Hazuki、Umemura Takashi、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 202 Pages: 48-55
  • DOI: 10.1016/j.chemosphere.2018.03.079
  • NAID: 120006864479
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Accumulation patterns and risk assessment of metals and metalloid in muscle and offal of free-range chickens, cattle and goat in Benin City, Nigeria (2018)
  • Author(s): Ogbomida Emmanuel Temiotan、Nakayama Shouta M.M.、Bortey-Sam Nesta、Oroszlany Balazs、Tongo Isioma、Enuneku Alex Ajeh、Ozekeke Ogbeide、Ainerua Martins Oshioriamhe、Fasipe Iriagbonse Priscillia、Ezemonye Lawrence Ikechukwu、Mizukawa Hazuki、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Ecotoxicol Environ Saf Volume: 151 Pages: 98-108
  • DOI: 10.1016/j.ecoenv.2017.12.069
  • NAID: 120006842182
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A glycomics approach to discover novel renal biomarkers in birds by administration of cisplatin and diclofenac to chickens (2018)
  • Author(s): Ishii C、Ikenaka Y、Ichii O、Nakayama S M M、Nishimura S-I、Ohashi T、Tanaka M、Mizukawa H、Ishizuka M
  • Journal Title: Poultry Science Volume: 97 Issue: 5 Pages: 1722-1729
  • DOI: 10.3382/ps/pey016
  • Peer Reviewed / Open Access
• [Journal Article] Human Health Risk from Consumption of Marine Fish Contaminated with DDT and Its Metabolites in Maputo Bay, Mozambique (2018)
  • Author(s): Thompson L. A.、Ikenaka Y.、Yohannes Y. B.、Ichise T.、Ito G.、Bortey-Sam N.、van Vuren J. J.、Wepener V.、Smit N. J.、Darwish W. S.、Nakayama S. M. M.、Mizukawa H.、Ishizuka M.
  • Journal Title: Bulletin of Environmental Contamination and Toxicology Volume: 100 Issue: 5 Pages: 672-676
  • DOI: 10.1007/s00128-018-2323-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between human exposure to heavy metals/metalloid and occurrences of respiratory diseases, lipid peroxidation and DNA damage in Kumasi, Ghana (2018)
  • Author(s): Bortey-Sam Nesta、Ikenaka Yoshinori、Akoto Osei、Nakayama Shouta M.M.、Asante Kwadwo A.、Baidoo Elvis、Obirikorang Christian、Mizukawa Hazuki、Ishizuka Mayumi
  • Journal Title: Environ Pollut. Volume: 235 Pages: 163-170
  • DOI: 10.1016/j.envpol.2017.12.005
  • NAID: 120006820161
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex and site differences in urinary excretion of conjugated pyrene metabolites in the West African Shorthorn cattle (2018)
  • Author(s): BORTEY-SAM Nesta、IKENAKA Yoshinori、AKOTO Osei、NAKAYAMA Shouta M.M.、MARFO Jemima T.、SAENGTIENCHAI Aksorn、MIZUKAWA Hazuki、ISHIZUKA Mayumi
  • Journal Title: Journal of Veterinary Medical Science Volume: 80 Issue: 2 Pages: 375-381
  • DOI: 10.1292/jvms.17-0410
  • NAID: 130006410766
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Characterization of Species Differences in Xenobiotic Metabolism in Non-experimental Animals (2017)
  • Author(s): 水川葉月、池中良徳、筧麻友、中山翔太、石塚真由美
  • Journal Title: YAKUGAKU ZASSHI Volume: 137 Issue: 3 Pages: 257-263
  • DOI: 10.1248/yakushi.16-00230-2
  • NAID: 130005396880
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2017-03-01
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] β-carotene and retinol reduce benzo[a]pyrene-induced mutagenicity and oxidative stress via transcriptional modulation of xenobiotic metabolizing enzymes in human HepG2 cell line (2017)
  • Author(s): Darwish Wageh Sobhy、Ikenaka Yoshinori、Nakayama Shouta、Mizukawa Hazuki、Thompson Lesa A、Ishizuka Mayumi
  • Journal Title: Environmental Science and Pollution Research Volume: 25 Issue: 7 Pages: 6320-6328
  • DOI: 10.1007/s11356-017-0977-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 鳥類で起こっているケミカルハザードとそのメカニズム (2017)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Journal Title: 日本野生動物医学会誌 Volume: 22 Pages: 69-72
  • NAID: 130006731438
  • Peer Reviewed / Open Access
• [Journal Article] 鳥類の鉛中毒の分析と原因 (2017)
  • Author(s): 石井千尋、中山翔太、水川葉月、池中良徳、石塚真由美
  • Journal Title: 中毒研究 Volume: 30 Pages: 363-367
  • Peer Reviewed / Open Access
• [Journal Article] Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model (2017)
  • Author(s): Sasaki Noboru、Ishi Kazuhiro、Kudo Nobuki、Nakayama Shouta M. M.、Nakamura Kensuke、Morishita Keitaro、Ohta Hiroshi、Ishizuka Mayumi、Takiguchi Mitsuyoshi
  • Journal Title: PLOS ONE Volume: 12 Issue: 11 Pages: e0188093-e0188093
  • DOI: 10.1371/journal.pone.0188093
  • Peer Reviewed / Open Access
• [Journal Article] Multidisciplinary field research in Kabwe, Zambia, towards better understanding of lead contamination of the city - A short report from a field survey (2017)
  • Author(s): Uchida Yoshitaka、Banda Kawawa、Nyambe Imasiku、Hamamoto Toru、Yoshii Yui、Munthali Kabenuka、Mwansa Mukuka、Mukuka Moses、Mutale Mubanga、Yabe John、Toyomaki Haruya、Beyene Yohannes Yared、Nakayama Shouta M. M.、Naruse Nobuyasu、Ishizuka Mayumi、Takahashi Yukihiro
  • Journal Title: BioRxiv Volume: -
  • DOI: 10.1101/096164
  • Open Access / Int'l Joint Research
• [Journal Article] Contamination Levels and Sources of Heavy Metals and a Metalloid in Surface Soils in the Kumasi Metropolis, Ghana (2017)
  • Author(s): Akoto O, Bortey-Sam N, Ikenaka Y, Nakayama SMM, Baidoo E, Yohannes YB, Ishizuka M
  • Journal Title: Journal of Health and Pollution Volume: 15 Pages: 28-39
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lead exposure in raptors from Japan and source identification using Pb stable isotope ratios (2017)
  • Author(s): Chihiro Ishii, Shouta M.M.Nakayama, Yoshinori Ikenaka, Hokuto Nakata, Keisuke Saito, Yukiko Watanabe, Hazuki Mizukawa, Shinsuke Tanabe, Kei Nomiyama, Terutake Hayashi, Mayumi Ishizuka
  • Journal Title: Chemosphere Volume: 186 Pages: 367-373
  • DOI: 10.1016/j.chemosphere.2017.07.143
  • NAID: 120006477493
  • Peer Reviewed / Open Access
• [Journal Article] Uridine Diphosphate-Glucuronosyltransferase (UGT) 2B Subfamily Interspecies Differences in Carnivores (2017)
  • Author(s): Kondo Takamitsu、Ikenaka Yoshinori、Nakayama Shouta M. M.、Kawai Yusuke K.、Mizukawa Hazuki、Mitani Yoko、Nomiyama Kei、Tanabe Shinsuke、Ishizuka Mayumi
  • Journal Title: Toxicological Sciences Volume: 158 Issue: 1 Pages: 90-100
  • DOI: 10.1093/toxsci/kfx072
  • Peer Reviewed / Open Access
• [Journal Article] Anthropogenic and naturally produced brominated phenols in pet blood and pet food in Japan (2017)
  • Author(s): Hazuki Mizukawa, Kei Nomiyama, Susumu Nakatsu, Miyuki Yamamoto, Mayumi Ishizuka, Yoshinori Ikenaka, Shouta M.M. Nakayama, Shinsuke Tanabe
  • Journal Title: Environmental Science & Technology Volume: 51 Issue: 19 Pages: 11354-11362
  • DOI: 10.1021/acs.est.7b01009
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of DDT contamination in house rat as a possible bioindicator in DDT-sprayed areas from Ethiopia and South Africa (2017)
  • Author(s): Yohannes Yared Beyene、Ikenaka Yoshinori、Ito Gengo、Nakayama Shouta M. M.、Mizukawa Hazuki、Wepener Victor、Smit Nico J.、Van Vuren Johan H. J.、Ishizuka Mayumi
  • Journal Title: Environmental Science and Pollution Research Volume: 24 Issue: 30 Pages: 23763-23770
  • DOI: 10.1007/s11356-017-9911-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concentrations and Human Health Risk Assessment of DDT and Its Metabolites in Free-range and Commercial Chicken Products from KwaZulu-Natal, South Africa (2017)
  • Author(s): Thompson LA, Ikenaka Y, Yohannes YB, van Vuren JJ, Wepener V, Smit NJ, Darwish WS, Nakayama SMM, Mizukawa H, Ishizuka M
  • Journal Title: Food Additives and Contaminants: Part A Volume: 34 Pages: 1959-1969
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sediment Metal Contamination in the Kafue River of Zambia and Ecological Risk Assessment (2017)
  • Author(s): M’kandawire Ethel、Choongo Kennedy、Yabe John、Mwase Maxwell、Saasa Ngonda、Nakayama Shouta M. M.、Bortey-Sam Nesta、Blindauer Claudia A.
  • Journal Title: Bulletin of Environmental Contamination and Toxicology Volume: 99 Issue: 1 Pages: 108-116
  • DOI: 10.1007/s00128-017-2089-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contamination status and accumulation characteristics of heavy metals and arsenic in five seabird species from the central Bering Sea (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Yared Beyene Yohannes, Yutaka Watanuki, Masaaki Fukuwaka, and Mayumi Ishizuka
  • Journal Title: Journal of Veterinary Medical Science Volume: 79 Issue: 4 Pages: 807-814
  • DOI: 10.1292/jvms.16-0441
  • NAID: 130007331465
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organochlorine pesticide contamination of foods in Africa: incidence and public health significance (2017)
  • Author(s): L. A. Thompson, W. S. Darwish, Y. Ikenaka, S. M. Nakayama, H. Mizukawa and M. Ishizuka
  • Journal Title: Journal of Veterinary Medical Science Volume: 79 Issue: 4 Pages: 751-764
  • DOI: 10.1292/jvms.16-0214
  • NAID: 130005568160
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Monitoring lead (Pb) pollution and identifying Pb pollution sources in Japan using stable Pb isotope analysis with kidney of wild rats. (2017)
  • Author(s): Nakata H*, Nakayama SMM*, Oroszlany B, Ikenaka Y, Mizukawa H, Tanaka K, Harunari T, Tanikawa T, Darwish WS, Yohannes YB, Saengtienchai A, Ishizuka M (* Equal contribution).
  • Journal Title: Int. J. Environ. Res. Public Health Volume: in press Issue: 1 Pages: 56-56
  • DOI: 10.3390/ijerph14010056
  • NAID: 120005981457
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Trace Element Contamination in Tissues of Four Bird Species from the Rift Valley Region, Ethiopia. (2017)
  • Author(s): Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: BECT Volume: 98 Issue: 2 Pages: 172-177
  • DOI: 10.1007/s00128-016-2011-4
  • NAID: 120006377485
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DDTs and other organochlorine pesticides in tissues of four bird species from the Rift Valley region, Ethiopia. (2017)
  • Author(s): Yohannes YB, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: Sci. Total. Environ. Volume: 574 Pages: 1389-1395
  • DOI: 10.1016/j.scitotenv.2016.08.056
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Excretion of polycyclic aromatic hydrocarbon metabolites (OH-PAHs) in cattle urine in Ghana. (2016)
  • Author(s): Bortey-Sam N, Ikenaka Y, Akoto O, Nakayama SMM, Marfo J, Saengtienchai A, Mizukawa H, Ishizuka, M.
  • Journal Title: Environmental Pollution Volume: 218 Pages: 331-337
  • DOI: 10.1016/j.envpol.2016.07.008
  • NAID: 120006539246
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Heavy metals and metalloid accumulation in livers and kidneys of wild rats around gold-mining communities in Tarkwa, Ghana. (2016)
  • Author(s): Bortey-Sam N*, Nakayama SMM*, Ikenaka Y, Akoto O, Baidoo E, Mizukawa H, Ishizuka M (* Equal contribution).
  • Journal Title: Journal of Environmental Chemistry and Ecotoxicology, Volume: 8 Issue: 7 Pages: 58-68
  • DOI: 10.5897/jece2016.0374
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Characterization of Equine Cytochrome P450: Role of CYP3A in the Metabolism of Diazepam (2016)
  • Author(s): Nakayama SMM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M
  • Journal Title: Journal of Veterinary Pharmacology and Therapeutics Volume: in press Issue: 5 Pages: 478-87
  • DOI: 10.1111/jvp.12303
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Feather mercury concentration in streaked shearwaters wintering in separate areas of southeast Asia (2016)
  • Author(s): Watanuki Y, Yamashita A, Ishizuka M, Ikenaka Y, Nakayama SMM, Ishii C, Yamamoto T, Ito M, Kuwae T, Trathan PN
  • Journal Title: Marine Ecology Progress Series Volume: 546 Pages: 263-269
  • DOI: 10.3354/meps11669
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Constitutive Effects of Lead on Aryl Hydrocarbon Receptor Gene Battery and Protection by β-carotene and Ascorbic Acid in Human HepG2 Cells. (2016)
  • Author(s): Darwish WS, Ikenaka Y, Nakayama SMM, Mizukawa H, Ishizuka M.
  • Journal Title: J. Food. Sci. Volume: 81 Issue: 1
  • DOI: 10.1111/1750-3841.13162
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Bioaccumulation and human health risk assessment of DDT and other organochlorine pesticides in an apex aquatic predator from a premier conservation area. (2016)
  • Author(s): Gerber R, Smit NJ, Van Vuren JH, Nakayama SMM, Yohannes YB, Ikenaka Y, Ishizuka M, Wepener V.
  • Journal Title: Sci. Total. Environ. Volume: 550 Pages: 522-533
  • DOI: 10.1016/j.scitotenv.2016.01.129
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Strain differences in cytochrome P450 mRNA and protein expression, and enzymatic activity among Sprague Dawley, Wistar, Brown Norway and Dark Agouti rats (2016)
  • Author(s): Nishiyama Y, Nakayama SMM, Watanabe KP, Kawai YK, Ohno M, Ikenaka Y, Ishizuka M.
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 4 Pages: 675-680
  • DOI: 10.1292/jvms.15-0299
  • NAID: 130007331491
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reliability of stable Pb isotopes to identify Pb sources and verifying biological fractionation of Pb isotopes in goats and chickens. (2016)
  • Author(s): Nakata H, Nakayama SMM, Yabe J, Liazambi A, Mizukawa H, Darwish WS, Ikenaka Y, Ishizuka M
  • Journal Title: Environ Pollut. Volume: 208 Pages: 395-403
  • DOI: 10.1016/j.envpol.2015.10.006
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Distribution and health risk assessment of organochlorine pesticides (OCP) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCP in tongue. (2016)
  • Author(s): Mahmoud AFA, IkenakaY, YohannesYB, DarwishWS, Eldaly EA, Morshdy AE, Nakayama SMM, MizukawaH, Ishizuka M.
  • Journal Title: Chemosphere Volume: 144 Pages: 1365-1371
  • DOI: 10.1016/j.chemosphere.2015.10.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] β-carotene and retinol contents in the meat of herbivorous ungulates with a special reference to their public health importance (2016)
  • Author(s): Darwish WS, Ikenaka Y, Morshdy AE, Eldesoky KI, Nakayama SMM, MizukawaH, Ishizuka M.
  • Journal Title: Journal of Veterinary Medical Science Volume: 78 Issue: 2 Pages: 351-354
  • DOI: 10.1292/jvms.15-0287
  • NAID: 130005131329
  • ISSN: 0916-7250, 1347-7439
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] ザンビア・カブエ鉱床における鉛汚染問題とその解決に向けた取り組み-KAbwe Mine Pollution Amelioration Initiative (KAMPAI Project)- (2018)
  • Author(s): 中山翔太、水川葉月、池中良徳、石塚真由美
  • Organizer: 第3回 北大部局間横断シンポジウム
  • Invited
• [Presentation] Lead levels in eggs in Kabwe, Zambia: implication of human exposure (2018)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Takeshi Kuritani, Mitsuhiro Nakagawa, Mayumi Ishizuka
  • Organizer: Society of Toxicology’s 57th Annual Meeting and ToxExpo
  • Int'l Joint Research
• [Presentation] 代謝酵素の動物種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 日本薬学会第137年会シンポジウム
  • Place of Presentation: 仙台国際センター、仙台市、宮城県
  • Year and Date: 2017-03-24
  • Invited
• [Presentation] Comparison of Food Products Contaminated by DDTs in South Africa and Mozambique (2017)
  • Author(s): Lesa A. Thompson, Yoshinori Ikenaka, Victor Wepener, Mayumi Ishizuka
  • Organizer: 19th International Conference on One Health
  • Int'l Joint Research
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] A Pilot Study on Exposure of Lead (Pb) and Its Blood Level Burden in Children from Kabwe, Zambia: Implication to the General Population (2017)
  • Author(s): Yared B. Yohannes, Shouta M.M. Nakayama, Haruya Toyomaki, John Yabe, Kaampwe Muzandu, Andrew Kataba,Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 第26回環境化学討論会
• [Presentation] Introduction of “The project for Visualization of impact of chronic / latent chemical hazard and Geo-Ecological Remediation” in Kabwe, Zambia (2017)
  • Author(s): Hokuto Nakata, Yoshitaka Uchida, Kaampwe Muzandu, Kawawa Banda, Shouta M.M. Nakayama, John Yabe, Toshifumi Igarashi, Mayumi Ito, Imasiku Nyambe, Mayumi Ishizuka
  • Organizer: The sixth Zambia Water Forum and Exhibition
  • Int'l Joint Research
• [Presentation] 高次栄養段階生物への化学物質の感受性の種差 (2017)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 2017年度第31回講演会
• [Presentation] Studies on polycyclic aromatic hydrocarbons formation in heat-treated meat (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 第44回日本毒性学会学術年会
• [Presentation] Utility evaluation for stable Pb isotopes analysis using potential sentinel animals to identify Pb pollution sources (2017)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: International Conference on Geology, Mining, Mineral and Groundwater Resources of the Sub-Saharan Africa
  • Int'l Joint Research
• [Presentation] 全国規模での鳥類への鉛曝露：曝露指標として骨の利用の可能性 (2017)
  • Author(s): 石井千尋，中山翔太，池中良徳，Kataba Andrew，齊藤慶輔，渡辺有希子，槇納好岐，松川岳久，久保田章乃，横山和仁，水川葉月，平田岳史，石塚真由美
  • Organizer: 第23回日本野生動物医学会大会
• [Presentation] Heavy metal residues in some ready-to-eat meat products marketed in Egypt (2017)
  • Author(s): Wageh Sobhy Darwish, Yoshinori Ikenaka, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Trends of childhood blood lead levels and remedial options in Kabwe, Zambia (2017)
  • Author(s): John Yabe, Haruya Toyomaki, Shouta MM Nakayama, Yared B. Yohannes,Kaampwe Muzandu, Andrew Kataba, Kennedy Choongo, Russell Dowling, Jack Caravanos, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] The relationship of Blood Lead Levels between mothers and infants in Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research / Invited
• [Presentation] Wild rat’s bio-distribution analysis for pesticide DDT from South Africa (2017)
  • Author(s): Tetsuro Ogawa, Yoshinori Ikenaka, Yared B Yohannes, Lesa Thompson, Johan van Vuren, Victor Wepener, Nico J Smit, Wynand Vlok, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 9th International Toxicology Symposium in Nigeria
  • Int'l Joint Research
• [Presentation] 鳥類医学の発展に向けた新規腎障害マーカーの探索 (2017)
  • Author(s): 石井千尋, 池中良徳, 川合佑典, 市居修, 中山翔太, 西村紳一郎, 大橋哲, 田中誠一, 齊藤慶輔, 渡邊有希子, 水川葉月, 石塚真由美
  • Organizer: 日本鳥学会２０１７年度大会
• [Presentation] Blood Lead Levels in chickens and dogs around lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarker in birds by transcriptome analysis of kidney tissues and glycomics analysis of plasma following renal damage in chicken model. (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] “First, do no harm” ? balancing the benefits of malaria control against the toxic effects of DDT use (2017)
  • Author(s): Lesa THOMPSON, Yoshinori IKENAKA, Yared YOHANNES, Atnafu ASSEFA, Johan VAN VUREN, Victor WEPENER, Nico SMIT, Wynand VLOK, Wageh Sobhy DARWISH, Shouta NAKAYAMA, Hazuki MIZUKAWA and Mayumi ISHIZUKA
  • Organizer: The 5th Sapporo Summer Seminar for One Health (SaSSOH)
  • Int'l Joint Research
• [Presentation] Effect of DDTs on gallinacins in the avian immune system (2017)
  • Author(s): Lesa Thompson, Yoshinori Ikenaka, Yared Yohannes, Johan van Vuren, Victor Wepener, Nico Smit, Atnafu Assefa, Wageh Sobhy Darwish, Shouta Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
  • Int'l Joint Research
• [Presentation] Discovery of renal biomarkers in birds by transcriptome analysis and glycomics analysis following kidney injury in chicken model (2017)
  • Author(s): Chihiro Ishii, Yoshinori Ikenaka,Yusuke K. Kawai, Osamu Ichii, Shouta. M. M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: The 10th International Meeting of the Asian Society of Conservation Medicine (ASCM), "One Health in Asia Pacific"
  • Int'l Joint Research
• [Presentation] Current trends of blood lead levels in Kabwe, Zambia (2017)
  • Author(s): Yared BeyeneYohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Hokuto Nakata, Kaampwe Muzandu, Andrew Kataba, Golden Zyambo, Hazuki Mizukawa, Yoshinori Ikenaka, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Extent of lead exposure in mothers and infants living around a "closed" lead mining area, Kabwe, Zambia (2017)
  • Author(s): Haruya Toyomaki, John Yabe, Shouta M.M. Nakayama, Yared B. Yohannes, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Hokuto Nakata, Russell Dowling, Jack Caravanos, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Reliability of stable lead isotope analysis for lead source identification and verifying biological fractionation of lead isotopes in goats and chicken (2017)
  • Author(s): Hokuto Nakata, Shouta MM Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh S Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Practical system integration for local community participation in lead contamination assessment in Kabwe, Zambia (2017)
  • Author(s): Shinsaku Nakamura, Kazuyo Hirose, Tomomi Takeda, Yoshitaka Uchida, Hokuto Nakata, Shouta MM Nakayama, Mayumi Ishizuka, John Yabe, Mayumi Ito, Toshifumi Igarashi
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Local distribution of Pb in mice using bioimaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) (2017)
  • Author(s): Shouta MM Nakayama, Masao Togao, Yoshinori Ikenaka, Hazuki Mizukawa, Yoshiki Makino, Ayano Kubota, Takehisa Matsukawa, Kazuhito Yokoyama, Takafumi Hirata, Mayumi Ishizuka
  • Organizer: 1st International KAMPAI Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Int'l Joint Research
• [Presentation] Evaluation of utility for stable lead isotope ratios to identify lead sources and verifying biological fractionation of lead isotopes in goats and chickens (2017)
  • Author(s): Hokuto Nakata, Shouta M.M. Nakayama, John Yabe, Allan Liazambi, Hazuki Mizukawa, Wageh Sobhy Darwish, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Elevated Blood Lead Levels among Children, Infants and Mothers in Kabwe, Zambia (2017)
  • Author(s): Yared Beyene Yohannes, John Yabe, Shota M.M. Nakayama, Haruya Toyomaki, Kaampwe Muzandu, Yoshinori Ikenaka, Hazuki Mizukawa, Russell Dowling, Jack Caravanos, Hokuto Nakata, Mayumi Ishizuka
  • Organizer: SETAC North America 38th Annual Meeting
  • Int'l Joint Research
• [Presentation] Evaluation of indoor residual spraying DDT for mosquito control: Tissue distribution and gene expression profiling in rat tissues (2017)
  • Author(s): Emmanuel Temiotan Ogbomida, Alex Ajeh Enuneku, Yoshinori Ikenaka, Yared Beyene Yohannes, Wageh Sobhy Darwish, Shouta M.M. Nakayama, Hazuki Mizukawa, Mayumi Ishizuka
  • Organizer: 環境ホルモン学会第20回研究発表会
• [Presentation] Monitoring of blood lead levels (BLLs) in dogs and chickens from lead pollution area, Kabwe, Zambia. (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
  • Organizer: International Doctoral Symposium on Sustainable Management of Resources and Environment in the 21st Century
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2016-11-09
  • Int'l Joint Research
• [Presentation] Lead exposure on human samples in African countries and lead pollution in Kabwe, Zambia. (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, John Yabe, Kaampwe Muzandu, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: The 4th Sapporo Summer Seminar for One Health (SaSSOH)
  • Place of Presentation: Hokkaido University, Sapporo, Japan
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] 家畜・家禽の鉛安定同位体生体内分別の種差および歩哨動物としての有用性評価 (2016)
  • Author(s): 栂尾正雄、中山翔太、John Yabe、池中良徳、中田北斗、石井千尋、水川葉月、Yared B. Yohannes、 Aksorn Saengtienchai、石塚真由美
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部、藤沢市、神奈川県
  • Year and Date: 2016-09-06
• [Presentation] Kabwe childhood lead poisoning: past, present and future (2016)
  • Author(s): John Yabe, Shouta MM Nakayama, Yoshinori Ikenaka, Yared B. Yohannes, Haruya Toyomaki, Kennedy Choongo, Kaampwe Muzandu and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research / Invited
• [Presentation] Lead exposure on human samples in African countries: a mini review (2016)
  • Author(s): Haruya Toyomaki, Shouta M.M. Nakayama, Yared B. Yohannes, Hazuki Mizukawa, Yoshinori Ikenaka and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research / Invited
• [Presentation] Risk Assessment of Heavy Metals via Consumption of Muscle and Offal of Free-Range Animals from Benin City (2016)
  • Author(s): Emmanuel Temiotan Ogbomida, Shouta M.M. Nakayama, Nesta Bortey-Sam, Balazs Oroszlany, Isioma Tongo, Alex Ajeh Enuneku, Ogbeide Ozekeke, Martins Oshioriamhe Ainerua, Iriagbonse Priscillia Fasipe, Lawrence Ikechukwu Ezemonye, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research / Invited
• [Presentation] Cytochrome P450 expression in the rabbit (2016)
  • Author(s): Walaa Fathy Saad Eldin, Wageh S. Darwish, Yoshinori Ikenaka, Shouta M. Nakayama, Hazuki Mizukawa and Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research
• [Presentation] Pb levels and isotope ratio profiles in kidneys of Japanese wild rats (2016)
  • Author(s): Shouta M.M. Nakayama, Hokuto Nakata, Balazs Oroszlany, Yoshinori Ikenaka, Hazuki Mizukawa, Kazuyuki Tanaka, Tsunehito Harunari, Tsutomu Tanikawa, Yared B. Yohannes, Aksorn Saengtienchai, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research / Invited
• [Presentation] Is there species difference of biological variation of lead (Pb) isotopic composition between livestock and poultry? (2016)
  • Author(s): Masao Togao, Shouta M.M. Nakayama, John Yabe, Hokuto Nakata, Yoshinori Ikenaka, Chihiro Ishii, Yared B. Yohannes, Hazuki Mizukawa, Wageh Sobhy Darwish, Aksorn Saengtienchai, Mayumi Ishizuka
  • Organizer: 8th International Toxicology Symposium in Africa
  • Place of Presentation: Gawharet Alahram Hotel, Giza, Egypt
  • Year and Date: 2016-08-29
  • Int'l Joint Research
• [Presentation] UGTの動物種差 (2016)
  • Author(s): 石塚 真由美、中山 翔太、水川 葉月、池中 良徳
  • Organizer: 第43回日本毒性学会学術年会
  • Place of Presentation: ウインクあいち、名古屋市、愛知
  • Year and Date: 2016-06-29
• [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites. (2016)
  • Author(s): Nesta Bortey-Sam, Yoshinori Ikenaka, Osei Akoto, Shouta M.M. Nakayama, Kwadwo A. Asante, Christian Obirikorang, Elvis Baidoo, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
  • Organizer: SETAC Europe 26th Annual Meeting
  • Place of Presentation: La Cite Nantes Congress Center, Nantes, France
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] KAMPAI -Team 2, PAST, PRESENT and FUTURE- (2016)
  • Author(s): Shouta M.M. Nakayama, John Yabe, Yared Beyene, Haruya Toyomaki, Kaampwe Muzandu, Kennedy Choongo, Hazuki Mizukawa, Yoshinori Ikenaka, Mayumi Ishizuka.
  • Organizer: Kick-Off Symposium for the “The Project for Visualization of impact of chronic/latent chemical hazard and Geo-Ecological Remediation in Zambia”
  • Place of Presentation: CRESTA Golfview Hotel, Lusaka, Zambia
  • Int'l Joint Research
• [Presentation] Human health risk due to polycyclic aromatic hydrocarbon (PAHs) exposure in Kumasi, Ghana; and excretion of PAH metabolites in cattle urine from urban and rural sites. (2016)
  • Author(s): Nesta Bortey-Sam, Yoshinori Ikenaka, Shouta M.M. Nakayama, Aksorn Saengtienchai, Hazuki Mizukawa, Mayumi Ishizuka.
  • Organizer: 第30回北海道薬物作用談話会
  • Place of Presentation: 北海道大学、札幌市、北海道
• [Presentation] Metal pollution problems in animals and children in Kabwe mining area, Republic of Zambia- Source Estimation by Stable Pb isotopes- (2016)
  • Author(s): 中山翔太
  • Organizer: 第16回北大若手研究者交流会
  • Place of Presentation: 北海道大学、札幌市、北海道
  • Invited
• [Presentation] 化学物質の汚染環境に生きる野生動物の適応戦略 (2016)
  • Author(s): 石塚真由美、中山翔太、水川葉月、池中良徳
  • Organizer: 一般社団法人日本環境化学会25周年記念講演会：「環境化学の今、そして未来へ－環境化学からの提言－」
  • Place of Presentation: 発明会館地下ホール、東京都港区
  • Invited
• [Book] 9th International Toxicology Symposium in Africa (2017)
  • Author(s): Ikenaka Y, Darwish WS, Johan JV, Wepner V, Moundipa PF, Akoto O, Ikechukwu EL, Ogbomida E, Enuneku A, Beyene Y, Yabe J, Nakayama SMM, Mizukawa H, Ishizuka M
  • Total Pages: 155
  • Publisher: Syobunsha
  • ISBN: 9780620767996
• [Book] KAbwe Mine Pollution Amelioration Initiative Project (KAMPAI) (2017)
  • Author(s): Nakayama SMM, Yabe J, Nakata H & Ishizuka M
  • Total Pages: 68
  • Publisher: Syobunsha
  • ISBN: 9784909032003
• [Book] トキシコロジー第3版（7章 環境毒性） (2017)
  • Author(s): 石塚真由美、中山翔太、鑪迫典久
  • Total Pages: 13
  • Publisher: 朝倉書店
• [Book] 8th International Toxicology Symposium in Africa (ISBN: 978-0-620-71287-3) (2016)
  • Author(s): Ikenaka Y, Darwish WS, Johan JV, Wepner V, Moundipa PF, Akoto O, Ikechukwu EL, Beyene Y, Yabe J, Nakayama SMM, Mizukawa H, Saengtienchai A, Ishizuka M.
  • Total Pages: 155
  • Publisher: Shoubunsya inc
• [Book] KAbwe Mining Pollution Amelioration Initiative Project (KAMPAI) (ISBN: 978-4-909032-68-3) (2016)
  • Author(s): Nakayama SMM, Yabe J & Ishizuka M et al
  • Total Pages: 160
  • Publisher: Shoubunsya inc
• [Remarks] 北海道大学 大学院獣医学研究院 毒性学教室
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks] ケミカルハザード問題の克服に向けた国際コミッション
  • URL: http://aa.vetmed.hokudai.ac.jp/
• [Remarks] 北海道大学 大学院獣医学研究院
  • URL: https://www.vetmed.hokudai.ac.jp/
• [Remarks] ザンビアにおける鉛汚染のメカニズムの解明と健康・経済リスク評価手法および予防・修復技術の開発
  • URL: http://satreps-kampai.vetmed.hokudai.ac.jp/
• [Remarks]
  • URL: http://tox.vetmed.hokudai.ac.jp/
• [Remarks]
  • URL: http://satreps-kampai.vetmed.hokudai.ac.jp/