| Project/Area Number |
16K16198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Chiba University |
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Principal Investigator |
Eguchi Akifumi 千葉大学, 予防医学センター, 助教 (70595826)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | メタボロミクス / 残留性有機汚染物質 / 重金属 / コホート調査 / 電気電子機器廃棄物 / 化学物質曝露影響解析 / 有害化学物質 / 環境 / 生体分子 / 分析科学 |
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| Outline of Final Research Achievements |
In this study, we investigated the exposure effect of environmental pollutants such as heavy metals and persistent organic pollutants (POPs) on humans by using metabolome analysis that comprehensively analyzes low molecular compounds in serum and urine; We tried to elucidate by analyzing the relationship between profiles of metabolome and residual concentrations of chemical substances.
In this study, residue levels of PCBs were related to glutathione and amino acid metabolism in maternal serum and the amino acid metabolism and ubiquinone and other terpenoid-quinone biosynthesis (energy metabolism) in cord serum, indicating disruption of metabolic pathways by PCB exposure in pregnant women and fetuses. Residue levels of Pb were associated with ABC transport, possibly related to the disruption of small-molecule transport in the kidney; amino acid, porphyrin, and chlorophyll metabolism; and possibly, the heme biosynthetic pathway.
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