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Evaluation of the effect of chemical exposure using metabolome analysis

Research Project

Project/Area Number 16K16198
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Risk sciences of radiation and chemicals
Research InstitutionChiba University

Principal Investigator

Eguchi Akifumi  千葉大学, 予防医学センター, 助教 (70595826)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsメタボロミクス / 残留性有機汚染物質 / 重金属 / コホート調査 / 電気電子機器廃棄物 / 化学物質曝露影響解析 / 有害化学物質 / 環境 / 生体分子 / 分析科学
Outline of Final Research Achievements

In this study, we investigated the exposure effect of environmental pollutants such as heavy metals and persistent organic pollutants (POPs) on humans by using metabolome analysis that comprehensively analyzes low molecular compounds in serum and urine; We tried to elucidate by analyzing the relationship between profiles of metabolome and residual concentrations of chemical substances.
In this study, residue levels of PCBs were related to glutathione and amino acid metabolism in maternal serum and the amino acid metabolism and ubiquinone and other terpenoid-quinone biosynthesis (energy metabolism) in cord serum, indicating disruption of metabolic pathways by PCB exposure in pregnant women and fetuses. Residue levels of Pb were associated with ABC transport, possibly related to the disruption of small-molecule transport in the kidney; amino acid, porphyrin, and chlorophyll metabolism; and possibly, the heme biosynthetic pathway.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Hanoi University of Science (VNU)(ベトナム)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Vietnam National University(ベトナム)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Exploration of potential biomarkers and related biological pathways for PCB exposure in maternal and cord serum: A pilot study in birth cohort study in Chiba, Japan.2017

    • Author(s)
      Eguchi A, Sakurai K, Watanabe M, Mori C.
    • Journal Title

      Environ Int.

      Volume: 102 Pages: 157-164

    • DOI

      10.1016/j.envint.2017.02.011

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance2017

    • Author(s)
      Miki Takashi、Lee Eun Young、Eguchi Akifumi、Sakurai Kenichi、Sawabe Yuji、Yoshida Tomohiko、Saito Keiko、Yokoh Hidetaka、Ishikawa Ko、Yokote Koutaro、Kuzuya Takeshi、Miki Eishi、Mori Chisato、Nomura Fumio
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 印刷中 Issue: 3 Pages: 512-521

    • DOI

      10.1111/jdi.12719

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of early postnatal exposure to a low dose of decabromodiphenyl ether (BDE-209) on serum metabolites in male mice2016

    • Author(s)
      Akifumi Eguchi, Hidenobu Miyaso, Chisato Mori
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 41 Issue: 5 Pages: 667-675

    • DOI

      10.2131/jts.41.667

    • NAID

      130005266226

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Risk analysis of fetal exposure of PCBs with omics analysis, using maternal blood, umbilical cord and cord blood in birth cohort study in Japan2017

    • Author(s)
      Chisato Mori, Akifumi Eguchi, Kenichi Sakurai, Kaori Tachibana, Emiko Todaka
    • Organizer
      SOT 56th Annual Meeting
    • Place of Presentation
      ボルティモア, アメリカ合衆国
    • Year and Date
      2017-03-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exploration of lead exposure related biological pathways in Vietnamese acid-lead battery recycling workers2017

    • Author(s)
      Akifumi Eguchi, Kei Nomiyama, Kenichi Sakurai, Pham Thi Kim Trang, Pham Hung Viet, Shin Takahashi, Hisato Iwata, Shinsuke Tanabe, Emiko Todaka, Chisato Mori
    • Organizer
      Chemical Hazard Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of fetal exposure of PCBs with omics analysis such as microbiome, epigenome and metabolome analyses using maternal blood, umbilical cord blood and cord tissues in birth cohort study named Chiba Study of Mother and Children’s Health (C-MACH)2017

    • Author(s)
      Chisato Mori, Akifumi Eguchi, Kenichi Sakurai, Kaori Tachibana, Emiko Todaka
    • Organizer
      ociety of Toxicology - Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The relationship between congener profiles of PCBs and levels of metabolome in maternal serum and H19 methylation in cord tissues2017

    • Author(s)
      Chisato Mori, Akifumi Eguchi, Hidenobu Miyaso, Kenichi Sakurai
    • Organizer
      環境ホルモン学会第20回研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メタボローム解析による血清中PCBs曝露マーカーの探索2017

    • Author(s)
      江口 哲史, 櫻井 健一, 渡邉 応宏, 森千里
    • Organizer
      第22回日本環境毒性学会研究発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メタボローム解析による母体血清および臍帯血清中PCBs曝露マーカーの探索2016

    • Author(s)
      江口 哲史, 櫻井 健一, 渡邉 応宏, 森 千里
    • Organizer
      環境ホルモン学会 第19回研究発表会
    • Place of Presentation
      文部科学省研究交流センター, 茨城県, つくば市
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] A pilot study on metabolome analysis of PCB exposure in maternal and umbilical serum in Chiba cohort study of Mother and Children’s Health (C-MACH)2016

    • Author(s)
      Akifumi Eguchi, Kenichi Sakurai, Chisato Mori
    • Organizer
      5th Conference on Prenatal Programming and Toxicity
    • Place of Presentation
      北九州国際会議場, 福岡県, 北九州市
    • Year and Date
      2016-11-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] メタボローム解析による血清中PCBs曝露マーカーの探索 C-MACHコホートにおけるPCBs曝露とその影響解析2016

    • Author(s)
      江口 哲史, 櫻井 健一, 渡邉 応宏, 森 千里
    • Organizer
      第22回 日本環境毒性学会研究発表会
    • Place of Presentation
      愛媛大学, 愛媛県, 松山市
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] PCB levels in human serum in C-Mach cohort, Chiba, Japan: A pilot study2016

    • Author(s)
      Akifumi Eguchi, Kenichi Sakurai, Norimichi Suzuki, Masahiro Watanabe, Chisato Mori
    • Organizer
      36th International Symposium on Halogenated Persistent Organic Pollutants
    • Place of Presentation
      フィレンツェ, イタリア
    • Year and Date
      2016-08-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] メタボロミクスを用いたヒ素汚染地域住民の影響評価2016

    • Author(s)
      阿草 哲郎, 江口 哲史, Nguyen Minh Tue, Vi Thi Mai Lan, Tu Binh Minh, Pham Thi Kim Trang, 高橋 真 , Pham Hung Viet, 田辺 信介, 岩田 久人
    • Organizer
      第25回 環境化学討論会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター, 新潟県, 新潟市
    • Year and Date
      2016-06-08
    • Related Report
      2016 Research-status Report
  • [Remarks] Researchgate

    • URL

      https://www.researchgate.net/profile/Akifumi_Eguchi

    • Related Report
      2016 Research-status Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/siero5335/

    • Related Report
      2016 Research-status Report
  • [Remarks] Google scholar citations

    • URL

      https://scholar.google.com/citations?user=in2FlHwAAAAJ

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 妊娠糖尿病の発症リスクの診断用バイオマーカー2017

    • Inventor(s)
      櫻井健一、森千里、江口哲史、山本緑
    • Industrial Property Rights Holder
      国立大学法人千葉大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 境界型糖尿病の診断用バイオマーカー2016

    • Inventor(s)
      三木 隆司, 李 恩瑛, 江口 哲史, 櫻井 健一
    • Industrial Property Rights Holder
      三木 隆司, 李 恩瑛, 江口 哲史, 櫻井 健一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-176169
    • Filing Date
      2016-09-09
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-08-19  

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