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Preventative effects of selenium compounds on lifestyle related diseases

Research Project

Project/Area Number 16K16274
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionGunma University

Principal Investigator

Yamazaki Chiho  群馬大学, 大学院医学系研究科, 助教 (20506422)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsセレン / 生活習慣病 / 抗酸化物質 / がん / 微量元素 / スルフォラファン / 機能性食品 / 肥満 / 動物モデル / スルフォララン
Outline of Final Research Achievements

The purpose of this study was to examine the preventive effect of antioxidants such as selenium, a trace element, and sulforaphane, which is abundant in broccoli-sprouts, on lifestyle-related diseases.
Although we were unable to obtain the direct evidence that these antioxidants prevent the development of lifestyle-related diseases, our study showed that selenium supplementation before cancer radiation therapy can reduce side effects.

Academic Significance and Societal Importance of the Research Achievements

日本人の男性の約 2 人に 1 人、女性の 3 人に1人は生涯のうちにがんにかかるといわれている。本研究では、放射線治療前のセレン補充により副作用を軽減できる可能性を示した。がん患者は病気や治療により微量栄養素が不足しがちである。放射線治療前に患者の血中セレン濃度を測定し、必要に応じてセレン補充を行うことは、副作用を軽減し、患者のQOLを維持・向上するうえで有用であると期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2019

All Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Further updates on the clinical studies of selenium supplementation in radiotherapy patients2019

    • Author(s)
      Koyama H, Handa E, Puspitasari I M, Abdulah R, Yamazaki C, Kameo S, Nakano T.
    • Organizer
      International Society for Trace Element research in Humans 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Micronutrients status and anemia in under-developed region in Indonesia2019

    • Author(s)
      Chiho Yamazaki, Sekar Ayu Paramita, Nova Sumihartini, Eka Suradji, Rizky Abdulah, Hiroshi Koyama
    • Organizer
      International Society for Trace Element research in Humans 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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