| Project/Area Number |
16K16275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIJIMA Tomoko 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (80568270)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 軽度マグネシウム欠乏 / ラット / 肝臓 / 栄養素代謝 / トランスクリプトーム解析 / マグネシウム欠乏食 / マグネシウム / DNAマイクロアレイ |
|---|
| Outline of Final Research Achievements |
In experiments with rats, bodily magnesium (Mg) state largely depended on dietary Mg quantity; serum Mg was lower in 0.02% Mg diet group than 0.04% Mg diet group, although common serum indexes were not changed in 0.02% Mg diet group compared to control diet group.
Genetically, however, the numbers of significantly changed hepatic genes were much more in 0.02% Mg diet group than in 0.04% Mg diet group. In both cases, the changed genes included those for lipid-glucose metabolism, immune response, and cell adhesion. It is thus suggested that even a small decrease a dietary Mg quantity can influence the gene expressions for these physiologically important events in the liver.
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