Study of GIPR signaling in adipose tissue under high-fat diet condition: Analysis of adipose tissue specific GIP receptor-deficient mice
Project/Area Number |
16K16276
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | GIP / インクレチン / 脂肪肝 / インスリン抵抗性 / 肥満 / 消化管ホルモン / GIP |
Outline of Final Research Achievements |
GIP receptor (GIPR) directly induces energy accumulation in adipose tissue in vitro. However, the importance of the direct effect of GIPR signaling on adipose tissue in vivo remains unclear. In this study, we generated adipose tissue-specific GIPR knockout (KO) mice and investigated the direct actions of GIP in adipose tissue. Under high-fat diet (HFD)-fed conditions, KO mice had significantly lower body weight and lean body mass compared with those in floxed GIPR (WT) mice, although the fat volume was not significantly different between the two groups. Interestingly, insulin resistance, liver weight, and hepatic steatosis were reduced in HFD-fed KO mice. Plasma levels of interleukin-6 (IL-6), a proinflammatory cytokine that induces insulin resistance, were reduced in HFD-fed KO mice compared with those in HFD-fed WT mice. Thus, GIPR signaling in adipose tissue plays a critical role in HFD-induced insulin resistance and hepatic steatosis in vivo, which may involve IL-6 signaling.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice.2017
Author(s)
Joo E, Harada N, Yamane S, Fukushima T, Taura D, Iwasaki K, Sankoda A, Shibue K, Harada T, Suzuki K, Hamasaki A, Inagaki N.
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Journal Title
Diabetes.
Volume: 66
Issue: 4
Pages: 868-868
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 脂肪組織におけるGIPシグナルは、高脂肪食摂取下のインスリン抵抗性や脂肪肝の形成に関与する2016
Author(s)
城尾恵里奈, 原田範雄, 山根俊介, 福島徹, 田浦大輔, 岩崎可南子, 渋江公尊, 三小田亜希子, 村田由貴, 鈴木和代, 浜崎暁洋, 稲垣暢也
Organizer
第59回日本糖尿病学会年次学術集会
Place of Presentation
京都
Year and Date
2016-05-19
Related Report