| Project/Area Number |
16K16277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe University |
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Principal Investigator |
Kanno Ayumi 神戸大学, 医学研究科, 医学研究員 (60757285)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / アミノ酸 / 2型糖尿病 / インスリン / 膵β細胞 / インスリン翻訳 / 高脂肪食 / 食科学 |
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| Outline of Final Research Achievements |
Our objective was to elucidate the mechanism of GCN2 activation in pancreatic β-cells under high fat feeding. We have demonstrated that insulin translation was enhanced and GCN2 was activated in mice islets fed a high fat diet.
We discovered that general amino acids were decreased and uncharged tRNAs were increased in the islets of wild type mice fed a high fat diet, compared with those of mice fed a normal chow diet. However, these changes were not seen in other tissues. We considered that during high fat feeding, increased systemic insulin demand increases insulin biosynthesis in pancreatic β-cells, which decreased amino acids and increased tRNA levels, and lead to GCN2 activation.
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