The effect of an amino acid sensor GCN2 on the development of type 2 diabetes mellitus during high fat diet feeding
| Project/Area Number |
16K16277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kobe University |
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Principal Investigator |
Kanno Ayumi 神戸大学, 医学研究科, 医学研究員 (60757285)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / アミノ酸 / 2型糖尿病 / インスリン / 膵β細胞 / インスリン翻訳 / 高脂肪食 / 食科学 |
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| Outline of Final Research Achievements |
Our objective was to elucidate the mechanism of GCN2 activation in pancreatic β-cells under high fat feeding. We have demonstrated that insulin translation was enhanced and GCN2 was activated in mice islets fed a high fat diet.
We discovered that general amino acids were decreased and uncharged tRNAs were increased in the islets of wild type mice fed a high fat diet, compared with those of mice fed a normal chow diet. However, these changes were not seen in other tissues. We considered that during high fat feeding, increased systemic insulin demand increases insulin biosynthesis in pancreatic β-cells, which decreased amino acids and increased tRNA levels, and lead to GCN2 activation.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.2018
Author(s)
Takai T, Matsuda T, Matsuura Y, Inoue K, Suzuki E, Kanno A, Kimura-Koyanagi M, Asahara SI, Hatano N, Ogawa W, Kido Y.
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Journal Title
Biochem Biophys Res Commun.
Volume: 497
Issue: 1
Pages: 451-456
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Docosahexaenoic acid reduced palmitic acid-induced endoplasmic reticulum stress in pancreatic β-cells2018
Author(s)
Suzuki E, Matsuda T, Kawamoto T, Takahashi H, Mieda Y, Matsuura Y, Takai T, Kanno A, Kimura-Koyanagi M, Asahara S.-i, Inoue H, Ogawa W, Kido Y
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Journal Title
Kobe Journal of Medical Sciences
Volume: 印刷中
NAID
Related Report
Peer Reviewed
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[Journal Article] Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells.2017
Author(s)
Kawada Y, Asahara SI, Sugiura Y, Sato A, Furubayashi A, Kawamura M, Bartolome A, Terashi-Suzuki E, Takai T, Kanno A, Koyanagi-Kimura M, Matsuda T, Hashimoto N, Kido Y.
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Journal Title
PLoS ONE
Volume: 12
Issue: 9
Pages: e0184435-e0184435
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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